Action of interferon and its inducers aginst nonviral infectious agents

Vilček, Ján

doi:10.1001/archinte.126.1.69

Cited by 12 publications

(2 citation statements)

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“…Almost concurrently, IFN was shown to inhibit the appearance of intracellular inclusions formed by Chlamydia psittaci, an obligate intracellular bacterium (Sueltenfuss and Pollard, 1962). The latter finding was followed by demonstrations that type I IFN inhibits intracellular multiplication of protozoa, rickettsia, and other intracellular bacteria (reviewed in Stewart, 1979;Vilcek and Jahiel, 1970). Among other early recognized pleiotropic activities of type I IFNs were also enhancement of the lytic action of cytotoxic T cells for tumor target cells (Lindahl et al, 1972) and enhancement of MHC antigen expression (Lindahl et al, 1976).…”

Section: Discussionmentioning

confidence: 98%

Fifty Years of Interferon Research: Aiming at a Moving Target

Vilček

2006

Immunity

129

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Section: Discussionmentioning

confidence: 98%

Fifty Years of Interferon Research: Aiming at a Moving Target

Vilček

2006

Immunity

129

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“…Type I IFNs are a family of genes that exhibit potent antiviral activities Isaacs and others 1957;Nagano and Kojima 1958;Vilcek and Jahiel 1970). In humans and mice, the type I IFN family is composed of IFNA (14 subtypes), IFNB, IFNK, IFNW, IFNT, and IFNE [reviewed by Pestka (2007)].…”

Section: Type I Ifnsmentioning

confidence: 99%

Post-Transcriptional Regulation of Interferons and Their Signaling Pathways

Savan

2014

Journal of Interferon & Cytokine Research

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Interferons (IFNs) are low molecular weight cell-derived proteins that include the type I, II, and III IFN families. IFNs are critical for an optimal immune response during microbial infections while dysregulated expression can lead to autoimmune diseases. Given its role in disease, it is important to understand cellular mechanisms of IFN regulation. 3' untranslated regions (3' UTRs) have emerged as potent regulators of mRNA and protein dosage and are controlled through multiple regulatory elements including adenylate uridylate (AU)-rich elements (AREs) and microRNA (miRNA) recognition elements. These AREs are targeted by RNA-binding proteins (ARE-BPs) for degradation and/or stabilization through an ARE-mediated decay process. miRNA are endogenous, single-stranded RNA molecules ~22 nucleotides in length that regulate mRNA translation through the miRNA-induced silencing complex. IFN transcripts, like other labile mRNAs, harbor AREs in their 3' UTRs that dictate the turnover of mRNA. This review is a survey of the literature related to IFN regulation by miRNA, ARE-BPs, and how these complexes interact dynamically on the 3' UTR. Additionally, downstream effects of these post-transcriptional regulators on the immune response will be discussed. Review topics include past studies, current understanding, and future challenges in the study of post-transcriptional regulation affecting IFN responses.

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The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

Weinstock‐Guttman

et al. 1995

Annals of Neurology

203

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Action of interferon and its inducers aginst nonviral infectious agents

Cited by 12 publications

References 53 publications

Fifty Years of Interferon Research: Aiming at a Moving Target

Fifty Years of Interferon Research: Aiming at a Moving Target

Post-Transcriptional Regulation of Interferons and Their Signaling Pathways

The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

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