Action of hydroxyethyl starch on the flow properties of human erythrocyte suspensions

Corry, W. D.; Jackson, L.J.; Seaman, G. V. F.

doi:10.3233/bir-1983-20526

Cited by 15 publications

(6 citation statements)

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“…Results of studies based on other methods have independently concluded that the dependence of the extent of aggregation on HES concentration exhibits a maximum (15). Specific details of these results are different from those determined here, which is not surprising since the methods employed also differ considerably.…”

Section: Discussion and Summarycontrasting

confidence: 55%

NMR investigation of hydroxyethyl starch‐induced aggregation of human erythrocytes

1987

Magnetic Resonance in Med

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Aggregation of human erythrocytes at physiological hematocrit by hydroxyethyl starch (HES) was investigated with a 1H nuclear magnetic resonance method which measures the erythrocyte mean water exchange time, tau a. A relationship that takes into account the effect of the aggregate as the water-exchanging unit was used to transform tau a values into the number of cells per aggregate, n. The procedure permits the determination of the time course of aggregation as well as its initial and equilibrium status. The values of n at equilibrium range from about 2 to 4 cells over the concentration of 1 to 5% HES in isotonic saline. The aggregation of erythrocytes in the presence of HES was found to follow first-order kinetics. The feasibility of this technique for application in the study of diseased states is indicated.

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Section: Discussion and Summarycontrasting

confidence: 55%

NMR investigation of hydroxyethyl starch‐induced aggregation of human erythrocytes

1987

Magnetic Resonance in Med

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“…As a comparative study, the shear rate dependencies of the viscosities of all of the plasma substitute solutions were measured. All solutions showed constant viscosities, indicating that they are all Newtonian fluids, [35][36][37] as shown in Table 1 and in Supporting Information.…”

Section: Viscosity and Shear Stress Of Hbv Suspended In Plasmamentioning

confidence: 89%

Rheological Properties of Hemoglobin Vesicles (Artificial Oxygen Carriers) Suspended in a Series of Plasma-Substitute Solutions

et al. 2007

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Hemoglobin vesicles (HbV) or liposome-encapsulated Hbs are artificial oxygen carriers that have been developed for use as transfusion alternatives. The extremely high concentration of the HbV suspension (solutes, ca. 16 g/dL; volume fraction, ca. 40 vol %) gives it an oxygen-carrying capacity that is comparable to that of blood. The HbV suspension does not possess a colloid osmotic pressure. Therefore, HbV must be suspended in or co-injected with an aqueous solution of a plasma substitute (water-soluble polymer), which might interact with HbV. This article describes our study of the rheological properties of HbV suspended in a series of plasma substitute solutions of various molecular weights: recombinant human serum albumin (rHSA), dextran (DEX), modified fluid gelatin (MFG), and hydroxylethyl starch (HES). The HbV suspended in rHSA was nearly Newtonian. Other polymers-HES, DEX, and MFG-induced HbV flocculation, possibly by depletion interaction, and rendered the suspensions as non-Newtonian with a shear-thinning profile (10(-4)-10(3) s(-1)). These HbV suspensions showed a high storage modulus (G') because of the presence of flocculated HbV. However, HbV suspended in rHSA exhibited a very low G'. The viscosities of HbV suspended in DEX, MFG, and high-molecular-weight HES solutions responded quickly to rapid step changes in shear rates of 0.1-100 s(-1) and a return to 0.1 s(-1), indicating that flocculation is both rapid and reversible. Microscopically, the flow pattern of the flocculated HbV that perfused through microchannels (4.5 microm deep, 7 microm wide, 20 cmH2O applied pressure) showed no plugging. Furthermore, the time required for passage was simply proportional to the viscosity. Collectively, the HbV suspension viscosity was influenced by the presence of plasma substitutes. The HbV suspension provides a unique opportunity to manipulate rheological properties for various clinical applications in addition to its use as a transfusion alternative.

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“…Because of the presence of HES, the viscosity of UW solution at 4°C increased by a factor of 2.5 when compared with the viscosity of the same solution at 37°C (12). Analyzing the effect of HES on the rheologic properties of blood, Corry et al (13) have drawn the attention to the aggregating effect of HES on red blood cells (RBC). The pathogenic potential of RBC aggregates prevails within the microcirculation, leading to altered flow dynamics and microvessel occlusive events (14,15).…”

mentioning

confidence: 98%

Hyperaggregating Effect of Hydroxyethyl Starch Components and University of Wisconsin Solution on Human Red Blood Cells

Morariu

Plaats²,

Oeveren³

et al. 2003

Transplantation

114

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Action of hydroxyethyl starch on the flow properties of human erythrocyte suspensions

Cited by 15 publications

References 0 publications

NMR investigation of hydroxyethyl starch‐induced aggregation of human erythrocytes

NMR investigation of hydroxyethyl starch‐induced aggregation of human erythrocytes

Rheological Properties of Hemoglobin Vesicles (Artificial Oxygen Carriers) Suspended in a Series of Plasma-Substitute Solutions

Hyperaggregating Effect of Hydroxyethyl Starch Components and University of Wisconsin Solution on Human Red Blood Cells

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