Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Allard, Bruno; Jacquemond, Vincent; Lemtiri‐Chlieh, Fouad; Pourrias, B; Rougier, O

doi:10.1111/j.1476-5381.1991.tb12493.x

Cited by 3 publications

(5 citation statements)

References 21 publications

(40 reference statements)

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“…(2) Berthiau et al (1989), in the moderately ischaemic rat isolated heart, have suggested a contribution of an intracellular realkalinization through the Na'-H' exchange process. Recently, the stimulation of the Na'-H' antiport by heptaminol has been evoked to explain its ability to stop the decline in tension in frog isolated twitch muscle fibre (Allard et al, 1991). An alkalinization has also been reported and shown to be concomitant with [Ca2+]i increase in squid giant axon during perfusion with n-alkanols and amines (Vassort et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the stimulation of the Na'-H' antiport by heptaminol has been evoked to explain its ability to stop the decline in tension in frog isolated twitch muscle fibre (Allard et al, 1991). An alkalinization has also been reported and shown to be concomitant with [Ca2+]i increase in squid giant axon during perfusion with n-alkanols and amines (Vassort et al, 1986).…”

Section: Effects Of Heptaminol On Ica Recovery From Inactivationmentioning

confidence: 98%

“…Since the early 1950's (Loubatieres, 1951), heptaminol (6amino 2-methyl heptanol) has been described as a cardiotonic molecule, mainly in cardiac ischaemic preparations and in drug-induced hypotension. Although some indications have been given about the mechanisms underlying these effects (Coraboeuf & Boistel, 1953;Garrett et al, 1962;Berthiau et al, 1989; see also Allard et al, 1991 on skeletal muscle), the action of heptaminol on ionic currents remains less understood. Due to the structure of its molecule, heptaminol is related both to alcohol and amine hydrocarbon derivatives.…”

Section: Introductionmentioning

confidence: 99%

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Alteration of the L‐type calcium current in guinea‐pig single ventricular myocytes by heptaminol hydrochloride

Peineau

Mongo

Guennec

et al. 1992

British J Pharmacology

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1 The effects of heptaminol on calcium current amplitude and characteristics were studied in single ventricular myocytes of guinea-pig by use of the whole cell configuration of the patch clamp technique. 2 A concentration-dependent decrease in 'Ca amplitude was observed. At heptaminol concentration as low as 10-6 M, this effect was observed in only two cells (n = 6). At 10-5 M the reduction of ICa was of 30± 15% (n =11). 3 The current recovery from inactivation at -40 mV holding potential (HP) seemed less sensitive to perfusion with heptaminol (> 10-6 M). However, at -80 mV HP the overshoot of the recovery curve was decreased by heptaminol. 4 Both at -40 mV and -80 mV HP, heptaminol (10-' M) significantly increased the steady state inactivation of ICa 5 As previously proposed by others to explain the effects of membrane active substances, the effects of heptaminol may result from alterations in cell membrane properties and possibly from an increase in intracellular free calcium ion concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Heptaminol On Ica Recovery From Inactivationmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alteration of the L‐type calcium current in guinea‐pig single ventricular myocytes by heptaminol hydrochloride

Peineau

Mongo

Guennec

et al. 1992

British J Pharmacology

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“…Diaphragm muscle stretch was studied with a device and protocol described and provided by Allard B [ 23 ] with several modifications. A bundle from middle part of lateral costal region of the diaphragm was dissected and the tendinous end was left intact while the other end was cut free of the rib and ligated with a fine copper wire for use in mounting preparation.…”

Section: Methodsmentioning

confidence: 99%

Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model

Eyenga

Roussel

Rey

et al. 2021

ICMx

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Background To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome c oxidase activity and content, and their relationship to diaphragm strength in an experimental model of sepsis. Methods A cecal ligation and puncture (CLP) protocol was performed in 12 rats while 12 controls underwent sham operation. Half of the rats in each group were paralyzed and mechanically ventilated. We performed blood gas analysis and lactic acid assays 6 h after surgery. Afterwards, we measured diaphragm strength and mitochondrial oxygen consumption, ATP and ROS generation, and cytochrome c oxidase activity. We also measured malondialdehyde (MDA) content as an index of lipid peroxidation, and mRNA expression of the proinflammatory interleukin-1β (IL-1β) in diaphragms. Results CLP rats showed severe hypotension, metabolic acidosis, and upregulation of diaphragm IL-1β mRNA expression. Compared to sham controls, spontaneously breathing CLP rats showed lower diaphragm force and increased susceptibility to fatigue, along with depressed mitochondrial oxygen consumption and ATP production and cytochrome c oxidase activity. These rats also showed increased mitochondrial ROS generation and MDA content. Mechanical ventilation markedly restored mitochondrial oxygen consumption and ATP production in CLP rats; lowered mitochondrial ROS production by the complex 3; and preserved cytochrome c oxidase activity. Conclusion In an experimental model of sepsis, early initiation of mechanical ventilation restores diaphragm mitochondrial function.

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“…Diaphragm muscle stretch was studied with a device and protocol described and provided by Allard and Caillé [40,41] with several modi cations. A bundle from middle part of lateral costal region of the diaphragm was dissected and the tendinous end was left intact while the other end was cut free of the rib and ligated with a ne copper wire for use in mounting preparation.…”

Section: In Vitro Diaphragm Contractile Assessmentmentioning

confidence: 99%

Mechanical Ventilation Preserves Diaphragm Mitochondrial Function in a Rat Sepsis Model

Eyenga

Roussel

Rey

et al. 2020

Preprint

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Background: To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome-c oxidase activity and content, and their relationship to diaphragm strength in an experimental model of sepsis.Methods: A cecal ligation and puncture (CLP) protocol was performed in 12 rats while 12 controls underwent sham-operation. Half of the rats in each group were paralyzed and mechanically ventilated. We performed blood gas analysis and lactic acid assays 6 hours after surgery. Afterwards, we measured diaphragm strength and mitochondrial oxygen consumption, ATP and ROS generation, and cytochrome-c oxidase activity. We also measured malondialdehyde (MDA) content as an index of lipid peroxidation, and mRNA expression of the pro-inflammatory interleukin-1β (IL-1β) in diaphragms.Results: CLP rats showed severe hypotension, metabolic acidosis, and upregulation of diaphragm IL-1β mRNA expression. Compared to sham controls, spontaneously breathing CLP rats showed lower diaphragm force and increased susceptibility to fatigue, along with depressed mitochondrial oxygen consumption and ATP production and cytochrome-c oxidase activity. These rats also showed increased mitochondrial ROS generation and MDA content. Mechanical ventilation markedly restored mitochondrial oxygen consumption and ATP production in CLP rats; lowered mitochondrial ROS production by the complex 3; and preserved cytochrome-c oxidase activity.Conclusion: In an experimental model of sepsis, early initiation of mechanical ventilation restores diaphragm mitochondrial function.

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Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Cited by 3 publications

References 21 publications

Alteration of the L‐type calcium current in guinea‐pig single ventricular myocytes by heptaminol hydrochloride

Alteration of the L‐type calcium current in guinea‐pig single ventricular myocytes by heptaminol hydrochloride

Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model

Mechanical Ventilation Preserves Diaphragm Mitochondrial Function in a Rat Sepsis Model

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