Action of gastrointestinal hormones on the myoelectric activity of the sphincter of Oddi in living rabbit

Sarles, J C; Delecourt, P; Castello, Hélio José; Gaeta, L.; Nacchiero, M; Amoros, Jean Pierre; Devaux, M.A.; Awad, Rana

doi:10.1016/0167-0115(81)90005-7

Cited by 19 publications

(8 citation statements)

References 17 publications

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“…We found that SOSB duration would be more reliable than amplitude for evaluating SO function. We observed that the SO EMG changes in the basal, excited and suppressed states were the same as those detected by other studies 22,23 . Overall our results confirm that the CE is comparable with the NE in terms of recording efficacy and reliability.…”

Section: Discussionsupporting

confidence: 90%

The feasibility and reliability of using circular electrode for sphincter of Oddi electromyography in anaesthetised rabbits

Chen

Dong

et al. 2009

Neurogastroenterology Motil

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Sphincter of Oddi manometry (SOM) is the gold standard for assessing sphincter of Oddi dysfunction (SOD), but is considered a diagnostic sensitivity of 30-80% and associated with significant complications of pancreatitis. Electromyography (EMG) of sphincter of Oddi (SO) using a circular electrode (CE) may be useful in improving diagnostic accuracy and reducing complications. To evaluate the feasibility and reliability of the CE, we record myoelectric activity of SO in rabbits using the CE to compare with the traditional needle electrode (NE). The CE was prepared using a double-channel biogel catheter with two silver rings at the head of the catheter. The CE was then inserted into the lumen of the SO through the duodenal papilla, and myoelectric activity was recorded in the SO in 30 rabbits. An EMG recorded using an NE was performed at the same time, when the SO was in basal state, after injection of cholecystokinin and N-butylscopolamine bromide. Electromyographs recorded by the two methods were then evaluated. Satisfactory SO EMGs were acquired using the CE without any injury. Simultaneous recording revealed a very similar traces and one-to-one correspondence of SO spike bursts (SOSB). Linear regression analysis showed a significant direct correlation between the two methods for SOSB duration and amplitude. The results suggested that CE was comparable with NE in terms of recording efficacy. The CE also has advantages of easy fixation, accurate localisation, broad applicability and ease of achieving satisfactory outcomes without trauma, compared with the NE.

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Section: Discussionsupporting

confidence: 90%

The feasibility and reliability of using circular electrode for sphincter of Oddi electromyography in anaesthetised rabbits

Chen

Dong

et al. 2009

Neurogastroenterology Motil

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“…3 In addition, interspecies differences have been reported. Thus, CCK stimulates SO motor activity in opossums and rabbits 4,5 but inhibits it in dogs and cats. 6,7 Recent immunohistochemical studies on pig SO, bile duct, gallbladder and duodenum have demonstrated that the calcitonin generelated peptide (CGRP) is present in nerves innervating SO and gallbladder, 8 suggesting that CGRP might play a role in the neural control of biliary motility.…”

Section: Introductionmentioning

confidence: 94%

Calcitonin gene‐related peptide (CGRP), a potent regulator of biliary flow

Rasmussen

Harling

Rehfeld

et al. 1997

Neurogastroenterology Motil

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This study was designed to investigate the effect of porcine calcitonin gene-related peptide (CGRP) on the motility of the porcine biliary tract in vivo. We measured the pressure in the gallbladder and sphincter of Oddi and, in separate experiments, the biliary flow into the duodenum during local intraarterial infusions of CGRP. To determine if the observed effect could be caused by release of cholecystokinin (CCK), we measured the CCK release. The basal pressure in the sphincter of Oddi increased dose-dependently from 5.9 +/- 0.5 mmHg to 11.5 +/- 2.1 mmHg and the motility index of phasic contractions (amplitude x frequency) from 47 +/- 8 to 347 +/- 64 mmHg s-1, at an infusion rate of 32.6 pmol kg-1 min-1. No effect was observed on the gallbladder pressure. CGRP at 6.5 pmol kg-1 min-1 significantly reduced the biliary flow into the duodenum to 47.7 +/- 6% of the basal level. Atropine, injected intravenously, completely abolished the contractile effect of CGRP. CGRP had no effect on the release of CCK. We conclude that CGRP increases biliary motility and hereby reduces bile flow, an effect which involves cholinergic but not cholecystokininergic mechanisms.

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“…Spontaneous phasic sphincter contractions are frequently absent in anesthetized primates but may be elicited by excitatory drugs. Cholecystokinin (CCK) inhibits sphincter of Oddi contractile activity in the human, dog, and cat (10,59) but stimulates contraction in the opossum and rabbit (8,158,159). Animals without a gallbladder have negligible sphincter of Oddi tone (110).…”

Section: Species Variationmentioning

confidence: 99%

“…Subsequently CCK was shown to elicit sphincter of tractile activity in the rabbit, guinea pig, and opossum (8,158,159,204). Cholecystokinin also stimulates pancreatic enzyme secretion and enhances hepatic bile flow.…”

Section: Pharmacologymentioning

confidence: 99%