Action of delta sleep inducing peptide on monoamine oxidase and acetylcholinesterase activity in subcellular fractions from rabbit brain formationsin vivo

Доведова, Е. Л.; Ашмарин, И. П.

doi:10.1007/bf00830773

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Previous studies showed that DSIP in vitro and in vivo activates monoamine oxidase A and increases the concentrations of serotonin and 5'-hydroxyindoleacetic acid in brain subfractions from rabbits and Wistar rats [6,10]. It was hypothesized that this peptide modulates activity of the serotoninergic system.…”

Section: Resultsmentioning

confidence: 99%

Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

Доведова¹,

Khrustalev²,

Khudoerkov³

2005

Bull Exp Biol Med

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Activity of enzymes catalyzing synthesis and degradation of serotonin and dopamine in brain structures of Wistar and August rats was measured biochemically under normal conditions and after short-term exposure to delta-sleep-inducing peptide. The effects of the test peptide manifested in activation of the serotoninergic system and inhibition of the dopaminergic system, particularly in the caudate nucleus. These changes were most pronounced in the brain of Wistar rats.

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Section: Resultsmentioning

confidence: 99%

Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

Доведова¹,

Khrustalev²,

Khudoerkov³

2005

Bull Exp Biol Med

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“…We have shown that long-term periodic adaptation (LTA) to hypoxia is accompanied by a transformation in the activity of the brain respiratory chain which manifests itself in suppressed respiration and intensified oxidative phosphorylation, altered oxidative activity of respiratory substrates [3], a decreased concentration of cytochromes, and an increased number of brain mitochondria [2]. These data suggest that LTA modifies the activity of the respiratory chain enzymes.…”

Section: Abstract: Adaptation; Hypoxia; Enzymatic Activity; Respiratmentioning

confidence: 99%

“…It has been shown that, in addition to normalizing sleep, this peptide activates the monoaminergic transmitter and serotoninergic systems and, being an opiate receptor agonist, displays antidepressant and analgetic activities [3,11]. DSIP raises the resistance of animals to emotional stress [7], prevents their death from cardiovascular disorders [4], and elicits an antiarrhythmic effect in emotional stress [8].…”

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confidence: 99%

The effect of delta-sleep-inducing peptide on the Ca-transporting system of the sarcoplasmic reticulum and activity of the myocardial antioxidant enzymes

et al. 1996

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It is demonstrated that immobilization stress against the background of lowered catalase activity impairs the function of the sarcoplasmic reticulum Ca pump, particularly at high Ca 2+ levels. The membranes of intraceltular Ca 2+ depots are destroyed much more rapidly than in the control, which results in Ca 2 § release. Administration of delta sleep-inducing peptide to control animals results in a 30% increase in catalase activity for an unchanged level of superoxide dismutase and markedly improves the function of the Ca-transporting system at elevated levels of free Ca 2 § A long-term stress after administration of the peptide not only causes no damage to the Ca-transporting system but actually increases its efficiency (compared with the control) at a high catalase level.Key Words: delta sleep-inducing peptide; Ca pump; sarcoplasmic reticulum; superoxide dismutase; myocardium Stress-induced damage to myocardial ion-transporting systems: sarcolemmal Na,K-ATPase [6] and sarcoplasmic reticulum Ca-ATPase [13] resulting from the activation of lipid peroxidation (LPO) can be prevented by central and peripheral stress-limiting systems of the organism [5]. Adaptation to a short-term stress, which can prevent disturbances of the electrical stability of the heart and arrhythmias in stress, ischemia, reperfusion, myocardial infarction, and postinfarction cardiosclerosis [14], is an example of combined activation of the central and peripheral stresslimiting systems of the organism. Adaptation to stress also prevents stress-induced damage to the Na,K pump [6] and optimizes the function of the Ca pump [13], i.e., it triggers a mechanism that operates at the level of the heart, limits arrhythmias, and protects against alterations in Ca homeostasis.An important role of delta sleep-inducing peptide (DSIP) in adaptation has recently been recognized. It has been shown that, in addition to normalizing sleep, this peptide activates the monoaminergic transmitter and serotoninergic systems and, being an opiate receptor agonist, displays antidepressant and analgetic activities [3,11]. DSIP raises the resistance of animals to emotional stress [7], prevents their death from cardiovascular disorders [4], and elicits an antiarrhythmic effect in emotional stress [8]. Moreover, it prevents stress-induced sleep disorders in rabbits [15]. Administration of DSIP and its analogs forestalls activation of LPO in acute pancreatitis and cold stress and stabilizes tysosomal membranes [10]. Thus, DSIP elicits both central and peripheral effects, regardless of the route of administration. However, its effect on the electrical stability of the heart devel-

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“…7 It is also connected with inhibition of histamine and activation of GABA-ergic systems 8,9 and with inducing cerebral monoamine oxidase activity. [10][11][12] Finally, it has been postulated that DSIP modulates endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine. [13][14][15][16] Unfortunately, its mechanisms of action have never been fully determined.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of tritium labelled delta sleep‐inducing peptide

Giraud¹,

Morgat²,

Cavelier³

et al. 2001

Labelled Comp Radiopharmac

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SummaryThe a,b-dehydro precursor of the delta sleep-inducing peptide (DSIP) for tritiation was prepared prior to tritiation using a 3+6 fragment coupling strategy on a solid support. The first fragment, a,b-dehydrotripeptide, was prepared in solution in five steps in 79% overall yield while the second fragment was obtained by a step by step peptide synthesis on a Wang resin using an Fmoc strategy. The a,b-dehydrotripeptide was coupled to the fragment linked to the resin, followed by a deprotection/cleavage step to yield the a,b-dehydro-DSIP, 7. Catalytic reduction of unsaturated DSIP using tritium gas and palladium oxide as catalyst gave [ 3 H]DSIP having a specific activity of 1.184 TBq/mmol(32 Ci/mmol).

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Action of delta sleep inducing peptide on monoamine oxidase and acetylcholinesterase activity in subcellular fractions from rabbit brain formationsin vivo

Cited by 3 publications

References 3 publications

Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

The effect of delta-sleep-inducing peptide on the Ca-transporting system of the sarcoplasmic reticulum and activity of the myocardial antioxidant enzymes

Synthesis of tritium labelled delta sleep‐inducing peptide

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