Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines

Amargo, A. C.; Ferreira, S. H.

doi:10.1111/j.1476-5381.1971.tb07113.x

Cited by 40 publications

(28 citation statements)

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“…Although two different types of receptors have been postulated for the relaxant and contractile effects (Camargo & Ferreira, 1971;Boschcov et al, 1984), receptor binding studies with rat duodenum membrane preparations revealed a single binding site with an equilibrium dissociation constant of 1.0 x 1O-9M (Liebmann et al, 1987). Our present results, however, clearly indicate that different types of bradykinin receptor are involved in the two components of the response.…”

Section: Discussionmentioning

confidence: 99%

“…The differential effects of bradykinin potentiating peptides on the two components of the response, the finding that only the contractile component is subject to desensitization (tachyphylaxis), and the observation that des-Arg9-bradykinin elicits only a contractile response, have led to the proposal that two different receptor types may mediate the two components of the biphasic effect (Camargo & Ferreira, 1971; Boschcov et al, 1984). However, binding studies with plasma membrane preparations could not detect more than one class of binding sites and led to the suggestion that one type of bradykinin ' Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

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Selectivity of bradykinin analogues for receptors mediating contraction and relaxation of the rat duodenum

Paiva

Pereira

et al. 1989

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selectivity of bradykinin analogues for receptors mediating contraction and relaxation of the rat duodenum

Paiva

Pereira

et al. 1989

British J Pharmacology

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“…Bradykinin potentiation by ACEI might involve beside ACE inhibition, induction of a cross-talk mechanism between ACE and B 2 receptors (Mittra and Singh, 1998;Marcic et al, 1999;Houben et al, 2000;Mueller et al, 2006). Indeed, more than 30 years ago, an ACE-independent mechanism for BK potentiation by ACEI of B. jararaca venom was suggested (Camargo and Ferreira, 1971;Greene et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that Bj-BPPs may act by an ACEindependent mechanism (Camargo and Ferreira, 1971;Greene et al, 1972;Mueller et al, 2005Mueller et al, , 2006. A similar possibility has been raised for conventional ACEI (Marks et al, 1980;Mittra and Singh, 1998;Houben et al, 2000;Ignjatovic et al, 2002).…”

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confidence: 93%

Do the Cardiovascular Effects of Angiotensin-Converting Enzyme (ACE) I Involve ACE-Independent Mechanisms? New Insights from Proline-Rich Peptides ofBothrops jararaca

Ianzer

Santos²,

Etelvino³

et al. 2007

J Pharmacol Exp Ther

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Angiotensin-converting enzyme (ACE) inhibitors were developed based on proline-rich oligopeptides found in the venom of Bothrops jararaca (Bj) previously known as bradykinin-potentiating peptides (BPPs). However, the exact mechanism of action of BPPs remains unclear. The role of the ACE in the cardiovascular effects of two of naturally proline-rich oligopeptides (Bj-BPP-7a and Bj-BPP-10c) was evaluated in vitro and in vivo. Bj-BPP-7a does not potentiate the cardiovascular response to bradykinin and is a weak inhibitor of ACE C and N sites (K i ϭ 40,000 and 70,000 nM, respectively), whereas Bj-BPP-10c is a strong bradykinin potentiator and inhibitor of the ACE C site (K i ϭ 0.5 versus 200 nM for N site). Strikingly, both peptides, in doses ranging from 0.47 to 71 nmol/kg, produced long-lasting reduction (Ͼ6 h) in the mean arterial pressure of conscious spontaneously hypertensive rats (maximal change, 45 Ϯ 6 and 53 Ϯ 6 mm Hg for Bj-BPP-7a and Bj-BPP-10c, respectively). The fall in blood pressure was accompanied by variable degrees of bradycardia. In keeping with the absence of relationship between ACE-inhibitory and antihypertensive activities, no changes in the pressor effect of angiotensin I or in the hypotensive effect of bradykinin were observed at the peak of the cardiovascular effects of both peptides. Our results indicate that the antihypertensive effect of two Bj-BPPs containing the motif Ile-Pro-Pro is unrelated to their ability for inhibiting ACE or potentiating bradykinin (BK), indicating as a major component ACE and BK-independent mechanisms. These results are in line with previous observations suggesting ACE inhibition-independent mechanisms for angiotensin I-converting enzyme inhibitor.

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“…The (Ferreira, 1965), but subsequently a direct interaction of the potentiator with the receptor has been postulated (Camargo & Ferreira, 1971). If this is so, then the changes in the receptor brought about by BPP9a are not as effective for the analogues as they are for bradykinin.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Metabolism of Bradykinin Analogues and the Contribution of Angiotensin Converting Enzyme to Bradykinin Inactivation in Isolated Lungs

Bakhle

1977

British J Pharmacology

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I The activity and pulmonary metabolism of two peptides, 7-homo Pro-bradykinin and 8-homo Phebradykinin were studied in isolated systems. 2 Both analogues were about 50-70 times less active than bradykinin on the guinea-pig ileum and 70-160 times less active on isolated strips of cat terminal ileum. 3 The action of both analogues on guinea-pig ileum was potentiated (2.5-3.0 fold) by a bradykinin potentiating peptide (BPP9a) but less so than the action of bradykinin (4-5 fold).4 Like bradykinin, the 8-homo Phe analogue was extensively inactivated (>90%) in a single passage through the pulmonary circulation of guinea-pig or rat isolated lungs and this inactivation was prevented by pre-treatment of the lungs with BPP9a. 5The 7-homo Pro analogue was inactivated to a lesser degree in guinea-pig lungs (58%) and in rat lungs (89%) and its inactivation was not affected by BPP9a.6 It is concluded that the 8-homo Phe analogue is a substrate for the dipeptidylcarboxypeptidase (angiotensin I converting enzyme) of lung, whereas the 7-homo Pro analogue is not a substrate. 7 There is about four times as much dipeptidylcarboxypeptidase activity in guinea-pig isolated lungs as there is in rat isolated lungs.

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Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines

Cited by 40 publications

References 13 publications

Selectivity of bradykinin analogues for receptors mediating contraction and relaxation of the rat duodenum

Selectivity of bradykinin analogues for receptors mediating contraction and relaxation of the rat duodenum

Do the Cardiovascular Effects of Angiotensin-Converting Enzyme (ACE) I Involve ACE-Independent Mechanisms? New Insights from Proline-Rich Peptides ofBothrops jararaca

Pulmonary Metabolism of Bradykinin Analogues and the Contribution of Angiotensin Converting Enzyme to Bradykinin Inactivation in Isolated Lungs

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