Action of ascorbic acid on the healing of malnourished rats'skin wounds

Nai, Gisele Alborghetti; Manzoli, Louise Maria Freitas; Silva, Tayane Carvalho Isidoro da; Mamede, Larissa de Queiroz; Disconzi, Mary Ellen de Oliveira Martins; Giuffrida, Rogério

doi:10.1590/1415-52732014000400007

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Conventional analysis was blinded and performed by an experienced and quali ed observer, with an optical microscope (Labophot, Nikon, Japan) using the following scores to quantify collagen and reticular bers in the entire tumor area: 0, absent; 1, small; 2, moderate; and 3, large [12].…”

Section: Histopathological Analysismentioning

confidence: 99%

Predictive Assessment of the Consistency of Pituitary Adenomas Using Signal Intensity In Magnetic Resonance Imaging and Fractal Dimension of Histopathological Features

Gaia

Filho

Reyes

et al. 2022

Preprint

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PURPOSE Recent studies have evaluated the presence of correlations between the magnetic resonance imaging (MRI) characteristics of Pituitary Adenomas (PAs) and their intraoperative tumor consistency. In this sense, predicting the consistency of preoperative PAs can help in selecting the most appropriate surgical approach for patients. However, the current literature lacks valid conclusions, and few articles that addressed the topic showed conflicting results. This study aimed to determine whether there is a correlation between the consistency of PAs and conventional MRI sequences, such as ADC, DWI, and FIESTA, in addition to a histopathological study of collagen and reticulin in these lesions, using Masson’s trichrome, reticulin, and fractal dimension (FD). METHODS Preoperative assessment was performed using MRI sequences, surgeons' perception of intraoperative consistency, and histopathological features using conventional methods (Masson's Trichomium and Reticulin) and FD. RESULTS The correlation between the MRI sequences and intraoperative consistency of the tumors did not show statistical relevance, and it was not possible to establish a specific signal intensity (SI) value for hard, intermediate, or soft tumors. No statistically significant correlation between the consistency of the tumor and quantification of collagen fibers, in both FD and conventional analyses. CONCLUSION The analysis of traditional MRI sequences plus ADC and FIESTA was not able to predict the consistency of the PAs. Moreover, it was found that collagen fibers identified through Masson’s trichrome, reticulin, and FD methods were not statistically associated with tumor consistency.

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Section: Histopathological Analysismentioning

confidence: 99%

Predictive Assessment of the Consistency of Pituitary Adenomas Using Signal Intensity In Magnetic Resonance Imaging and Fractal Dimension of Histopathological Features

Gaia

Filho

Reyes

et al. 2022

Preprint

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“…A vitamina C, ou ácido ascórbico, é classificada como uma vitamina hidrossolúvel sintetizada pelo organismo dos animais, mas que também pode ser encontrada em alimentos de origem vegetal e de origem animal, mas em menores quantidades nessa última (Cavalari & Sanches, 2018;Cordeiro, 2012;Filho et al, 2019;Silva et al, 2018), sendo que ela auxilia o organismo na síntese de colágeno acelerando o processo de cicatrização e a neovascularização no ferimento (Cavalari & Sanches, 2018;Nai et al, 2014;Pessoa, 2014;Santana, 2019) atua também como antioxidante (Cordeiro, 2012;Filho et al, 2019;Pessoa, 2014;Silva et al, 2018) mantém células do organismo saudáveis, ajuda no combate à infecções e no fortalecimento do sistema imune dos seres vivos, na absorção de ferro pelo organismo (Cavalari & Sanches, 2018;Cosmo & Galeriani, 2020;Nai et al, 2014). É importante para a formação de colágenos pelas células ao atuar na hidrólise de lisina e prolina em protocolágeno se tornando posteriormente o colágeno e acelerando a regeneração tecidual e a neovascularização, melhora a atividade leucocitária e protege o tecido contra agentes oxidantes que causam a morte de células e atrapalham a neoformação tecidual, além de aumentar o nível de RNAm dos colágenos tipo I e III e se predecessores (Manela-Azulay,2003;Santana, 2019;Souza, 2015).…”

Section: Introductionunclassified

Comparação da propriedade cicatrizante dos géis de açúcar e Passiflora edulis

Santos

Tossato

Marin

et al. 2022

RSD

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O tratamento de feridas cirúrgicas e não cirúrgicas tem se transformado em um desafio cada vez maior na medicina veterinária, por conta da resistência à medicamentos antimicrobianos e do fato desses animais acabarem ingerindo os medicamentos de uso tópico, causando muitas vezes efeitos colaterais e a intoxicação desses animais, gerando maiores dificuldades no tratamento e no processo de cicatrização de soluções de continuidade. Dessa forma, buscar pela formulação de novos medicamentos de uso tópico que possuam a capacidade de tratar feridas, acelerar a cicatrização e que também possa ser ingerido pelo paciente, caso a espécie possua o hábito de se lamber, é de extrema importância na medicina veterinária. Com o objetivo de desenvolver um fármaco com essas características, esse projeto formulou três géis, com ingredientes naturais - açúcar cristal e polpa de Passiflora edulis (maracujá), que podem ser ingeridos pelos animais, e que após pesquisa literária, foi possível constatar que esses produtos possuem princípios ativos que auxiliam na cicatrização dessas feridas, fato corroborado ao final da pesquisa. Essa pesquisa aprovada pelo CEUA (comitê de ética para uso animal) do UniSALESIANO de Araçatuba – SP, com o protocolo nº121.

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The Use of Platelet-Rich Plasma and Rosuvastatin in Wound Healing in Rabbits: A Longitudinal Study

Tetila¹,

Breda²,

Nogueira³

et al. 2019

Adv Skin Wound Care

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OBJECTIVE To test the hypothesis that platelet-rich plasma (PRP) improves wound healing in rabbits by analyzing morphologic alterations in lesions with the use of PRP alone or combined with rosuvastatin (RSV). METHODS Eight adult male New Zealand rabbits were used in this study. Researchers created four wounds on the back of each rabbit with an 8-mm punch. The control wound was treated with a 0.9% sodium chloride solution. Experimental wounds were treated with PRP, RSV, or both PRP and RSV. Dressings were changed with a new application of PRP and RSV every 4 days for 16 days. Wounds were biopsied on days 0, 7, 10, 14, and 17 for histopathologic evaluation of the scar tissue. MAIN RESULTS Histopathology revealed reepithelialization in 100% of wounds treated with PRP alone after 17 days of treatment, compared with 50% of wounds treated with RSV alone and 75% of the wounds treated with PRP and RSV. Further, combining RSV and PRP reduced blood loss. The use of PRP alone induced 100% neovascularization, compared with 50% and 62.5% in wounds treated with PRP and RSV and RSV alone, respectively. All experimental wounds had a higher percentage of collagen fibers on day 17 postlesion when compared with control wounds (78.27% ± 4.69%). There were no significant differences among treatments; however, wounds treated with RSV alone had the lowest amount of collagen fibers (85.98% ± 3.51%). Wounds treated with PRP alone or PRP and RSV had 90.07% ± 6.20% and 90.76% ± 3.51% collagen fibers, respectively. CONCLUSIONS The results of this study indicate that PRP elicits higher healing activity in the first 7 days postlesion. Treatments with RSV alone or RSV and PRP did enhance other healing phases.

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Action of ascorbic acid on the healing of malnourished rats'skin wounds

Cited by 3 publications

References 20 publications

Predictive Assessment of the Consistency of Pituitary Adenomas Using Signal Intensity In Magnetic Resonance Imaging and Fractal Dimension of Histopathological Features

Predictive Assessment of the Consistency of Pituitary Adenomas Using Signal Intensity In Magnetic Resonance Imaging and Fractal Dimension of Histopathological Features

Comparação da propriedade cicatrizante dos géis de açúcar e Passiflora edulis

The Use of Platelet-Rich Plasma and Rosuvastatin in Wound Healing in Rabbits: A Longitudinal Study

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