Action of anti‐<scp>M</scp><sub>3</sub> muscarinic acetylcholine receptor <scp>I</scp>g<scp>G</scp> of primary <scp>S</scp>jögren's syndrome on the enzymatic antioxidant system in rat submandibular gland

Reina, Silvia; Rodríguez, Marcelo; Stranieri, Graciela; Borda, Enri

doi:10.1111/jop.12313

Cited by 8 publications

(8 citation statements)

References 30 publications

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“… 20 , 24 Recently, two clinical studies have shown that the immune responses stimulated by M3R could cause the failure of M3R signaling pathways, ultimately leading to the development of pSS. 25 , 26 M3R peptides are able to activate interferon (IFN)-γ-reactive T-cells, which then induce inflammation targeting the tissues expressing these peptides.…”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

“…In another murine study, the antibody to M3R has been reported to increase levels of antioxidants, ie, superoxide dismutase (SOD) and catalase (CAT). 26 Since dry eye disease in humans has been linked to abnormal antioxidant status, 28 Reina’s study provides a mechanistic link between the M3R autoantigen and the disease mechanism in dry eye disease.…”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

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Review of autoantigens in Sjögren’s syndrome: an update

Tong¹,

Koh²,

Thong³

2017

JIR

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Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by inflammation in exocrine glands, resulting in reduced secretion of tears and saliva, manifesting as xerophthalmia and xerostomia, respectively. It is commonly associated with Sjögren’s syndrome type A (Ro) and Sjögren’s syndrome type B (La) antigens. However, in most patients, the identity of the triggering antigen is not known. Factors such as genetics of histocompatibility, dysregulation of T-cells, B-cells and viral infections have been implicated. Several important studies on autoantigens in pSS have been published since a review in 2012, and the aim of this review is to provide an update on further peer-reviewed original articles in this field. Oxidative damage of Ro60 antigen may explain the epitope spreading during the immune activation in pSS. Immune-mediated destruction of the muscarinic receptor-3-expressing cells has been associated with a reduction in parasympathetic function, which could cause reduced secretory function of exocrine glands. Such a process also activates reactive oxidative species and antioxidants, which are linked to the triggering of inflammatory responses. Elevated levels of kallikrein, yet another antigen present in the lacrimal gland and other tissues, are similarly involved in triggering an autoimmune T-cell response against target glands. Studying additional antigens, the platelet-selectin and vasoactive intestinal peptides, in patients with pSS can help to elucidate the origin and process of autoimmunity, or even lead to potential biomarkers. In conclusion, the understanding of autoantigens has led to exciting major advances in the biology of pSS and may influence diagnosis and management of pSS in future.

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Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

Review of autoantigens in Sjögren’s syndrome: an update

Tong¹,

Koh²,

Thong³

2017

JIR

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“…The complex pathogenesis of SS is characterized by dysfunction of innate and adaptive immunity. The hallmarks of SS are lymphocytic in ltration of the exocrine glands and the presence of circulating autoantibodies (anti-Ro/SS-A, anti-La/SS-B) [2], as well as also autoantibodies directed against muscarinic acetylcholine type 3 receptors (M3R), which functionally inhibit salivary secretion [3].…”

Section: Introductionmentioning

confidence: 99%

Chemosensory Dysfunction, Oral Disorders and Oral Health-Related Quality Of Life in Patients with Primary Sjögren's Syndrome: Comparative Cross-Sectional Study

Gobeljić

Milić

Pejnović

et al. 2020

Preprint

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Abstract Background: The aim of this study was to evaluate chemosensory function and oral disorders in patients with primary Sjögren's syndrome (pSS) and to compare these findings with those of age- and gender-matched healthy controls.Methods: This comparative cross-sectional study included 58 patients with primary Sjögren’s syndrome (pSS) and 55 age- and gender-matched healthy controls. Olfactory and gustatory function, burning sensations in the tongue (BST) and halitosis were assessed. Oral health-related quality of life (OHRQoL) was evaluated using the short-form Oral Health Impact Profile (OHIP-14).Results: Patients with pSS had significantly lower self-reported visual analogue scale (VAS) smell score (8.6±2.2 vs. 9.6±0.7, p=0.016) and VAS taste score (9.5±0.7 vs. 8.5±2.1, p=0.014) than healthy controls. A greater proportion of patients with pSS had anosmia (3.8% vs. 0.0%) or hyposmia (36.5% vs. 13.2%) and ageusia for basic tastes: sweetness (34.0% vs. 7.5%), sourness (10.6 % vs. 0.0), saltiness (10.0% vs. 5.7%) or bitterness (19.1% vs. 1.9%) as evaluated using Sniffin Sticks test and taste stripts, respectively. A higher proportion of pSS patients complained of dysgeusia (52.6% vs. 9.4%, p<0.0001) and BST (45.6% vs. 0.0%, p<0.0001), while similar number of patients with pSS and controls reported halitosis (31.6% vs. 28.3%, p=0.434). The mean OHIP-14 score was significantly higher in patients with pSS (6.8±7.0 vs. 2.3±8.5, p<0.001) indicating patients’ poorer OHRQoL compared with controls. Conclusions: The majority of patients with pSS had impaired chemosensory function and indicators of oral health in comparison with the age- and gender-matched healthy controls. Further studies of oral hygiene habits and dietary intake of these patients are needed to ensure better management of oral health problems in patients with pSS.

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“…. The hallmarks of SS are lymphocytic infiltration of the exocrine glands and the presence of circulating autoantibodies (anti-Ro/ SS-A, anti-La/SS-B) [2], as well as autoantibodies directed against muscarinic acetylcholine type 3 receptors (M3R), which functionally inhibit salivary secretion [3].…”

Section: Introductionmentioning

confidence: 99%

Chemosensory dysfunction, Oral disorders and Oral health-related quality of life in patients with primary Sjögren’s syndrome: comparative cross-sectional study

Gobeljić¹,

Milić

Pejnović³

et al. 2020

BMC Oral Health

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Background: The aim of this study was to evaluate chemosensory function and oral disorders in patients with primary Sjögren's syndrome (pSS) and to compare these findings with those of age-and gender-matched healthy controls. Methods: This comparative cross-sectional study included 58 patients with primary Sjögren's syndrome (pSS) and 55 age-and gender-matched healthy controls. Olfactory and gustatory function, burning sensations in the tongue (BST) and halitosis were assessed. Oral health-related quality of life (OHRQoL) was evaluated using the short-form Oral Health Impact Profile (OHIP-14). Results: Patients with pSS had significantly lower self-reported visual analogue scale (VAS) smell score (8.6 ± 2.2 vs. 9.6 ± 0.7, p = 0.016) and VAS taste score (8.5 ± 2.1 vs. 9.5 ± 0.7, p = 0.014) than healthy controls. A greater proportion of patients with pSS had anosmia (3.8% vs. 0.0%) or hyposmia (36.5% vs. 13.2%) and ageusia for basic tastes: sweetness (34.0% vs. 7.5%), sourness (10.6% vs. 0.0), saltiness (10.0% vs. 5.7%) or bitterness (19.1% vs. 1.9%) as evaluated using Sniffin Sticks test and taste stripts, respectively. A higher proportion of pSS patients complained of dysgeusia (52.6% vs. 9.4%, p < 0.0001) and BST (45.6% vs. 0.0%, p < 0.0001), while similar number of patients with pSS and controls reported halitosis (31.6% vs. 28.3%, p = 0.434). The mean OHIP-14 score was significantly higher in patients with pSS (6.8 ± 7.0 vs. 2.3 ± 8.5, p < 0.001) indicating patients' poorer OHRQoL compared with controls. Conclusions: The majority of patients with pSS had impaired chemosensory function and indicators of oral health in comparison with the age-and gender-matched healthy controls. Further studies of oral hygiene habits and dietary intake of these patients are needed to ensure better management of oral health problems in patients with pSS.

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Action of anti‐M₃ muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland

Cited by 8 publications

References 30 publications

Review of autoantigens in Sjögren’s syndrome: an update

Review of autoantigens in Sjögren’s syndrome: an update

Chemosensory Dysfunction, Oral Disorders and Oral Health-Related Quality Of Life in Patients with Primary Sjögren's Syndrome: Comparative Cross-Sectional Study

Chemosensory dysfunction, Oral disorders and Oral health-related quality of life in patients with primary Sjögren’s syndrome: comparative cross-sectional study

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Action of anti‐M3 muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland

Cited by 8 publications

References 30 publications

Review of autoantigens in Sj&ouml;gren&rsquo;s syndrome: an update

Review of autoantigens in Sj&ouml;gren&rsquo;s syndrome: an update

Chemosensory Dysfunction, Oral Disorders and Oral Health-Related Quality Of Life in Patients with Primary Sjögren's Syndrome: Comparative Cross-Sectional Study

Chemosensory dysfunction, Oral disorders and Oral health-related quality of life in patients with primary Sjögren’s syndrome: comparative cross-sectional study

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Product

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Action of anti‐M₃ muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland

Review of autoantigens in Sjögren’s syndrome: an update

Review of autoantigens in Sjögren’s syndrome: an update