Action of anti-inflammatory agents on endotoxin-induced lung inflammation in mice

Herrmann, Ernest C.; Engle, Claire G.; Perlman, Preston L.

doi:10.1152/ajplegacy.1959.197.4.803

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At 6 hr, lung weight is close to control levels. At 24 hr it is increased and at 48 hr increased even more; similar results have been reported by others (Herrmann et al, 1959).…”

Section: Endotoxin Groupssupporting

confidence: 91%

“…The endotoxin was Difco Escherichia coli lipopolysaccharide. The method of Herrmann, Engle & Perlman (1959) was used to measure mouse lung inflammation. These authors, and others (Groupe, Dougherty & Manaker, 1956;Ginsberg, 1955) have shown that instillation of endotoxins or other irritants into nostrils of mice leads to a gradual development of lung inflammation, that the increase in lung weight is a satisfactory measure of inflammation, and that antiinflammatory drugs can reduce the irritant-induced increase in lung weight.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of inflammation and histamine formation by actinomycin D

Reilly

Schayer

1969

British J Pharmacology

View full text Add to dashboard Cite

. An inflammation model developed in other laboratories was used in this study. Mice given endotoxin intranasally develop lung inflammation which progresses in intensity for several days. Lung weight is a satisfactory measure of inflammation. . In lungs of mice treated intranasally with endotoxin, histidine decarboxylase was activated within 6 hr, before lung weight had increased substantially. Enzyme activity was near maximal at 24 hr but had dropped by 48 hr, at which time inflammation was increasing. The data are consistent with an early role for histamine in mediating inflammation, but not with an essential role in the later stages. . When actinomycin D, an inhibitor of RNA synthesis, was mixed with endotoxin solution and given to mice intranasally, both lung inflammation and histidine decarboxylase activation were markedly enhanced at 24 and 48 hr, relative to effects produced by endotoxin alone. . Evidence is presented that intranasal instillation of endotoxin into mice increases histamine formation in lung in vivo. . We previously found protein synthesis inhibitors, the only drugs shown capable of blocking histidine decarboxylase activation, to be powerful anti‐inflammatory agents. Now we have found that actinomycin D, the only drug shown capable of enhancing histidine decarboxylase activation, to be strongly pro‐inflammatory. These observations support a causative role for histamine in slowly‐developing inflammation, and also provide a rigorous test for the participation of other mediator candidates.

show abstract

“…At 6 hr, lung weight is close to control levels. At 24 hr it is increased and at 48 hr increased even more; similar results have been reported by others (Herrmann et al, 1959).…”

Section: Endotoxin Groupssupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Enhancement of inflammation and histamine formation by actinomycin D

Reilly

Schayer

1969

British J Pharmacology

View full text Add to dashboard Cite

show abstract

DDT and inflammatory responses

Gabliks¹,

McLean²

1979

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

Pantoea agglomerans Lipopolysaccharide Controls Nasal Discomfort—A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group Comparison Trial

Kohchi,

Uehiro,

Fukaya

et al. 2024

IJTM

View full text Add to dashboard Cite

The present study examined the effects of foods containing lipopolysaccharides from Pantoea agglomerans (LPSp) on eye–nose allergic symptoms using a double-blind, placebo-controlled, randomized, parallel-group comparative research design. Sixty-three Japanese individuals aged 20–65 years with eye–nose allergic symptoms were included in this study and assigned to the LPS (480 μg/day)-containing food and placebo groups. Data on the subjective eye–nose allergic symptoms and antiallergic medication during the 8-week period were evaluated. The immunoglobulin E (IgE) and eosinophil counts were measured as indicators that may be correlated with allergy. No significant group differences were found in the change in eye–nose allergic symptoms from baseline. However, the LPS group showed a significantly shorter duration of antiallergic medication use and lower total antiallergic drug score than the placebo group. The corrected nasal allergy score calculated by taking into account the antiallergic drug score at week 8 was predominantly lower in the LPS group. The IgE to house dust and cedar pollen and eosinophil counts tended to be lower in the LPS group, and the total IgE and eosinophil counts were significantly lower in the LPS group at week 4. In conclusion, our results indicate that LPS-containing foods alleviate eye–nose allergic symptoms and consequently lower the use of antiallergic drugs (UMIN000049974).

show abstract

Action of anti-inflammatory agents on endotoxin-induced lung inflammation in mice

Cited by 3 publications

References 0 publications

Enhancement of inflammation and histamine formation by actinomycin D

Enhancement of inflammation and histamine formation by actinomycin D

DDT and inflammatory responses

Pantoea agglomerans Lipopolysaccharide Controls Nasal Discomfort—A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group Comparison Trial

Contact Info

Product

Resources

About