Action of an Estrogen Antagonist on the Electrical and Mechanical Properties of the Rat Uterus in Vitro

Marshall, J. F.; O'brien, O. Patrick

doi:10.1210/endo-80-4-748

Cited by 8 publications

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“…Since retention and spacing is believed to be brought about by muscular activity in the myometrium, itself dependent on the oestrogen-progesterone environment, it is possible that the ICI 46,474, by modifying the oestrogen-progesterone balance, might alter the muscular activity with the resultant expulsion of eggs through the vagina. Though not established for ICI 46,474, it is relevant in this con¬ nection that the non-steroidal oestrogen antagonist [a(/>-methoxyphenyl)-/?-nitrostyryl]phenoxy)ethyl}pyrolidine, monocitrate) has been found to alter the electrical and mechanical properties of rat myometrium measured in vitro (Marshall & O'Brien, 1967). It has been shown that ICI 46,474 is not zygotoxic and since blastocysts were found in the uterus on Days 5 and 6 in treated animals yet remained unimplanted, it is considered that ICI 46,474 must affect the implantation process itself either directly or in¬ directly.…”

Section: Discussionmentioning

confidence: 94%

The Effects of Ici 46,474 on Ovum Transport and Implantation in the Rat

Major¹,

Heald²

1974

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The effects of the non-steroidal, postcoital, antifertility agent, ICI 46,474, on ovum transport and implantation in the rat have been examined. When administered as a single implantation-inhibiting dose on Day 2 of pregnancy, the compound had only a marginal effect on the transport of ova through the oviduct. After entering the uterus at approximately the normal time, however, 79 % of the eggs were lost by Day 6. The remaining eggs, while unimplanted, had shed their zonae pellucidae. When animals were treated on Day 2 of pregnancy with a dose of ICI 46,474 which reduced the size of implantation sites observed on Day 9, but which allowed pregnancy to occur, implantation was delayed by some 16 hr. It is concluded that ICI 46,474 given on

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Section: Discussionmentioning

confidence: 94%