“…There is some suggestion that CI 628 may not inhibit estradiol uptake in the central nervous system (Whalen and Gorzalka, 1973). However, others have demonstrated that CI 628 can suppress hypothalamic estradiol uptake (Perry, DiPasquale, Ferguson, Pozzi, and Rassaert, 1973) although this inhibition occurred in intact, but not in ovariectomized, females. There is little doubt that other pharmacologic agents can effectively compete for estradiol receptors in brain (Kahwanago, Heinrichs, and Hermann, 1970;van Kordelaar, Broekman, and van Rossum, 1975;Maurer and Wooley, 1971).…”