Action of 5Hz repetitive transcranial magnetic stimulation on sensory, motor and autonomic function in human spinal cord injury

Kuppuswamy, Annapoorna; Balasubramaniam, A.V.; Maksimovic, R.; Mathias, Christopher J.; Gall, Angela; Craggs, Michael; Ellaway, P H

doi:10.1016/j.clinph.2011.04.022

Cited by 67 publications

(90 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RTMS has been delivered over M1 and yielded mixed results on motor cortical circuits [105,106]. PAS and SAS have been attempted for the TA [22] and FDI [1] muscles, respectively, in SCI.…”

Section: Resultsmentioning

confidence: 99%

“…Real and not sham rTMS lead to reductions in the cSP recorded from the thenar muscles and also improved somatosensory percepts and ASIA motor scores at three weeks following stimulation. Kuppuswamy et al [106] delivered 900 pulses at 5 Hz in 2 second trains with an inter-train interval of 8 seconds over M1 muscle representations corresponding to hand or forearm muscles. Real or sham rTMS was delivered for five days at 80% of active motor threshold.…”

Section: Paired Associative Stimulation (Pas)mentioning

confidence: 99%

See 1 more Smart Citation

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

Bailey

Mi²,

Aimee³

et al. 2014

JNSK

View full text Add to dashboard Cite

Spinal cord injury may lead to complete or incomplete damage to ascending sensory and/or descending motor pathways and therefore alter neural circuits of the primary motor cortex. Transcranial magnetic stimulation (TMS) is a valuable tool for investigating the function of neural circuitry within primary motor cortex and also for promoting plasticity in these circuits for the ultimate purpose of improving the control of movement. For spinal cord injury, information about motor cortical circuits and TMS approaches to induce plasticity in these circuits is steadily emerging. In this review, we discuss TMS investigations of motor cortical circuitry and review TMS approaches to promote plasticity in motor cortical circuitry in spinal cord injury.

show abstract

“…RTMS has been delivered over M1 and yielded mixed results on motor cortical circuits [105,106]. PAS and SAS have been attempted for the TA [22] and FDI [1] muscles, respectively, in SCI.…”

Section: Resultsmentioning

confidence: 99%

Section: Paired Associative Stimulation (Pas)mentioning

confidence: 99%

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

Bailey

Mi²,

Aimee³

et al. 2014

JNSK

View full text Add to dashboard Cite

show abstract

“…9 Likewise, hand and arm gross motor skills were improved by a 5-day high-frequency rTMS regimen (5 Hz, 900 stimuli, subthreshold intensity for upper-limb muscles) in a more recent SCI study conducted in the same institution. 11 For repetitive magnetic stimulation of the leg cortical motor area, significant improvement in walking speed and ASIA lower-extremity motor scores was achieved by 15 daily sessions of high-frequency active (20 Hz, 1800 pulses, 90% RMT of upper-limb muscles) but not sham rTMS, both being combined with ambulation training. 10 Several studies comparing the effects of different rTMS sessions used washout periods of 2-4 weeks in duration.…”

Section: Alexeeva and Calancie Efficacy Of Quadropulse Rtms For Impromentioning

confidence: 99%

“…There are few reports on the potential functional benefits of motor cortical rTMS after SCI. [9][10][11] Multiple rTMS sessions appear to be more effective at eliciting CNS plasticity compared to single, discontinuous sessions. 31 Extending this finding, a regimen using 5 daily sessions of rTMS has been adopted in clinicallyoriented rTMS studies.…”

Section: Alexeeva and Calancie Efficacy Of Quadropulse Rtms For Impromentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of QuadroPulse rTMS for improving motor function after spinal cord injury: Three case studies

Alexeeva

Calancie

2014

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context/objective: To examine the effects of repetitive QuadroPulse transcranial magnetic stimulation (rTMS QP ) on hand/leg function after spinal cord injury (SCI). Design: Interventional proof-of-concept study. Setting: University laboratory. Participants: Three adult subjects with cervical SCI. Interventions: Repeated trains of magnetic stimuli were applied to the motor cortical hand/leg area. Several exploratory single-day rTMS QP protocols were examined. Ultimately we settled on a protocol using three 5-day trials of (1) rTMS QP only; (2) exercise only (targeting hand or leg function); and (3) rTMS QP combined with exercise. Outcome measures: Hand motor function was assessed by Purdue Pegboard and Complete Minnesota Dexterity tests. Walking function was based on treadmill walking and the Timed Up and Go test. Electromyographic recordings were used for neurophysiological testing of cortical (by single-and doublepulse TMS) and spinal (via tendon taps and electrical nerve stimulation) excitability. Results: Single-day rTMS QP application had no clear effect in the 2 subjects whose hand function was targeted, but improved walking speed in the person targeted for walking, accompanied by increased cortical excitability and reduced spinal excitability. All 3 subjects showed functional improvement following the 5-day rTMS QP intervention, an effect being even more pronounced after the five-day combined rTMS QP + exercise sessions. There were no rTMS QP -associated adverse effects. Conclusion: Our findings suggest a functional benefit of motor cortical rTMS QP after SCI. The effect of rTMS QP appears to be augmented when stimulation is accompanied by targeted exercises, warranting expansion of this pilot study to a larger subject population.

show abstract

The interaction of cortico-spinal pathways and sacral sphincter reflexes in subjects with incomplete spinal cord injury: A pilot study

Vásquez

Balasubramaniam

Kuppuswamy

et al. 2014

Neurourol. Urodynam.

View full text Add to dashboard Cite

show abstract

Action of 5Hz repetitive transcranial magnetic stimulation on sensory, motor and autonomic function in human spinal cord injury

Cited by 67 publications

References 50 publications

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

Efficacy of QuadroPulse rTMS for improving motor function after spinal cord injury: Three case studies

The interaction of cortico-spinal pathways and sacral sphincter reflexes in subjects with incomplete spinal cord injury: A pilot study

Contact Info

Product

Resources

About