Action Mechanisms of Small Extracellular Vesicles in Inflammaging

Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Alarcón-Veleiro, Carmen; Sacristán-Santos, M; Quintana, María Del Pilar Miranda; Morente-López, Miriam; Toro, Javier de; Silva-Fernández, Lucía; Rodríguez, Alba González; Arufe, M.C.; Labora, Juan Antonio Fafián

doi:10.3390/life12040546

Cited by 1 publication

(1 citation statement)

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“…One such study found that LAPTM4B is upregulated in the lung tissues of patients with IPF, and that this upregulation is associated with increased oxidative stress and cellular injury (67), while another found that LAPTM4B is also upregulated in the lung tissues of patients with COPD and that this upregulation is associated with increased inflammation and oxidative stress (68). LAPTM4B has been shown to regulate the accumulation of oxidative stress and inflammation in vitro, as well as modulating the activity of enzymes involved in cellular senescence (69). However, more research is needed to fully understand the role of LAPTM4B in aging processes.…”

Section: Discussionmentioning

confidence: 99%

Establishing a genomic radiation-age association for space exploration supplements lung disease differentiation

Ruprecht

Singhal

Schaefer

et al. 2023

Front. Public Health

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PurposeOne possible way to quantify each individual's response or damage from ionizing radiation is to estimate their accelerated biological age following exposure. Since there is currently no definitive way to know if biological age estimations are accurate, we aim to establish a rad-age association using genomics as its foundation.MethodsTwo datasets were combined and used to empirically find the age cutoff between young and old patients. With age as both a categorical and continuous variable, two other datasets that included radiation exposure are used to test the interaction between radiation and age. The gene lists are oriented in preranked lists for both pathway and diseases analysis. Finally, these genes are used to evaluate another dataset on the clinical relevance in differentiating lung disease given ethnicity and sex using both pairwise t-tests and linear models.ResultsUsing 12 well-known genes associated with aging, a threshold of 29-years-old was found to be the difference between young and old patients. The two interaction tests yielded 234 unique genes such that pathway analysis flagged IL-1 signaling and PRPP biosynthesis as significant with high cell proliferation diseases and carcinomas being a common trend. LAPTM4B was the only gene with significant interaction among lung disease, ethnicity, and sex, with fold change greater than two.ConclusionThe results corroborate an initial association between radiation and age, given inflammation and metabolic pathways and multiple genes emphasizing mitochondrial function, oxidation, and histone modification. Being able to tie rad-age genes to lung disease supplements future work for risk assessment following radiation exposure.

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Section: Discussionmentioning

confidence: 99%