Action Du Propyl-Thiouracile Donné À La Ratte Gestante Sur Les Parathyroïdes Et Sur La Calcémie Des Foetus. Remarques Sur La Physiologie Des Parathyroïdes

Jost, A; P, Pic; Maniey, J; Legrand, C

doi:10.1530/acta.0.0430618

Cited by 5 publications

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“…During the last days of pregnancy, the serum calcium level of the fetal rat is higher than that of the mother [3,4], The presence of fetal hypercalcemia in relation to the mother is reported by Pic et al [5], The injection of antiparathormone (PTH) serum to the rat fetus on day 21.5 results in a decrease in serum calcium and an increase in fetal serum phosphate [6]. The injection of PTH into the fetus results in an increase in fetal serum calcium.…”

Section: Introductionmentioning

confidence: 94%

Sensitivity of the Renal Adenylate Cyclase Receptor System to Parathormone during the Last Third of Pregnancy in the Rat

Gügi¹,

Mallet²

1989

Neonatology

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During the last third of pregnancy, the rat phospho-calcic metabolism is clearly modified. Sensitivity of the renal receptor to parathormone (PTH) was investigated over this period in the fetuses and their mothers. As early as day 16.5 of pregnancy, the fetal kidney is sensitive to bovine PTH (1–34) on the basis of cAMP production. Sensitivity declines on the last day of pregnancy. The newborn kidney showed a higher response to PTH 3 h after birth than after 24 h. The basal adenylate cyclase activity in renal membranes of maternal kidney does not change. The sensitivity to PTH and to fluoride both decreased on day 18.5. A desensitization process of the PTH receptor A-C system has to be studied in order to explain these results.

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Section: Introductionmentioning

confidence: 94%

Sensitivity of the Renal Adenylate Cyclase Receptor System to Parathormone during the Last Third of Pregnancy in the Rat

Gügi¹,

Mallet²

1989

Neonatology

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“…Calcium homeostasis has been much studied in the adult mammal, and there is an extensive literature which agrees that during late foetal life foetal total plasma calcium is greater than that of the mother [Rat: Krukowski and Lehr, 1963;Jost et al, 1963;dog: Hoskins andSnyder, 1927-8 and1933;monkey: MacDonald et al, 1965;cow: Robinson and Huffman, 1926;Plumlee et al, 1952;sheep: Bawden et al, 1965;guinea pig: Burnette et al, 1968;and man: Smith, 1951]. In some cases, differences of as much as 5 mg/100 ml.…”

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confidence: 99%

Calcium Homeostasis in the Foetal Guinea Pig

Graham

Scothorne

1970

Exp Physiol

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Plasma total calcium levels have been studied in pregnant guinea pigs and their foetuses from 26 days of gestation to term. Between 28 days and 33-39 days the foetal plasma calcium falls from nearly the maternal level (9.6 mg/100 ml.) to 5-5 mg/100 ml. Thereafter the foetal plasma calcium rises, reaching the maternal level at term. No trend is found in the maternal levels. Foetal skeletal ossification was studied using an alizarin stain technique. Ossification centres appeared first in the clavicle, face and skull at 26 days of gestation. After 27 days gestation (foetal plasma protein = 1 g/100 ml.) there is a steady rise in foetal plasma protein level and at term foetal and maternal levels are approximately equal. Between 41 days gestation and term foetal blood is consistently more acid than maternal blood and has a higher pCO2 and lower P02. There is no evidence of a progressive change during gestation in pH, P02 or pCO2 in either foetal or maternal blood. It is concluded that the fall in foetal plasma calcium between 28 days and 33-39 days gestation may be due to calcification of the foetal skeleton before the full establishment of calcium homeostasis in the foetus. Increasing foetal plasma protein concentration or foetal parathyroid activity may account for the rise in foetal plasma calcium after 33-39 days.

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“…The calcium levels in the fetal rat are higher titan in the mother during the last 6 days of gestation (Jost et al, 1963 ;Krukowski and Lehr, 1963;Pic, 1969). The control of plasma calcium levels in the fetus appears to depend in part on the parathyroid glands.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Fetal Rat Parathyroid Gland Activity during Hypocalcemia Induced by EDTA

Garel¹

1975

Neonatology

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Rat fetuses with or without parathyroid glands (intact or decapitated at 17.5 days of gestation) were injected subcutaneously with the disodium salt of EDTA at 21.5 days of gestation. In the two groups, the unchelated plasma calcium levels were measured within 180 min following the injection. The lowest plasma calcium values were observed 30 min after injection of EDTA in both groups of fetuses. In intact fetuses, the return of plasma calcium levels to normal was completed within 180 min. In decapitated fetuses, recovery was delayed. The marked difference in the recovery curves between the two groups establishes the role of the fetal parathyroid glands in controlling fetal hypocalcemia. Factors which may explain the high plasma calcium level in the rat fetus are discussed in relation to findings from previous reports.

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Action Du Propyl-Thiouracile Donné À La Ratte Gestante Sur Les Parathyroïdes Et Sur La Calcémie Des Foetus. Remarques Sur La Physiologie Des Parathyroïdes

Cited by 5 publications

References 0 publications

Sensitivity of the Renal Adenylate Cyclase Receptor System to Parathormone during the Last Third of Pregnancy in the Rat

Sensitivity of the Renal Adenylate Cyclase Receptor System to Parathormone during the Last Third of Pregnancy in the Rat

Calcium Homeostasis in the Foetal Guinea Pig

Assessment of Fetal Rat Parathyroid Gland Activity during Hypocalcemia Induced by EDTA

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