Action De Medicaments Psychotropes Sur Un Test De Comportement Chez La Souris (“Test De Tantale”)

Dumeur, G.; Hüe, B.; Mouries, M.A.; Lwoff, J.M.

doi:10.1016/b978-0-08-023768-8.52059-4

Abstracts 1978

DOI: 10.1016/b978-0-08-023768-8.52059-4

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Action De Medicaments Psychotropes Sur Un Test De Comportement Chez La Souris (“Test De Tantale”)

G. Dumeur¹,

B. Hüe²,

M.A. Mouries³

et al.

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1983

1985

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Psychopharmacological profile of clenbuterol

Frances

Poncelet

Danti

et al. 1983

Drug Development Research

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Frances, H., M. Poncelet, S. Danti, P. Goldschmidt, and P. Simon: Psychopharmacological profile of clenbuterol. Drug Dev. Res. 3:349-356, 1983.Clenbuterol, a P-adrenergic agonist known to enter the brain, has been studied in mice with a set of psychopharmacological tests. Clenbuterol has an ambiguous sedative effect: it reduces motor activity in a dose-dependent manner without modifying exploratory behavior in the open field; it does not potentiate the effect of pentobarbital. Clenbuterol decreases the search for food in starved mice. Regarding the tests in animals which are expected to reflect antidepressant activity in man (hypothermias induced by reserpine, oxotremorine or a high dose of apomorphine, potentiation of yohimbine toxicity) clenbuterol acts at doses much lower than those required with two other P-adrenergic agonists, isoproterenol and salbutamol. Moreover, the active doses of clenbuterol and salbutamol being nearly the same at a peripheral level, the ratio of the centrally and peripherally active doses is highly in favor of clenbuterol. This suggests that the effects of clenbuterol on depressed patients should be studied.

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Psychopharmacological profile of clenbuterol

Frances

Poncelet

Danti

et al. 1983

Drug Development Research

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Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol

Frances

Diquet

Goldschmidt

et al. 1985

J. Neural Transmission

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The effect in mice of chronic administration of the beta-adrenergic agonist clenbuterol was studied using four pharmacological tests, two of which are predictive of antidepressant activity in man. The suppressive effect of acute administration of the beta-adrenergic agonist in two tests unrelated to antidepressant activity, locomotor activity and investigation of food, was attenuated after chronic treatment. However, in the two tests which are predictive of antidepressant activity, antagonism of reserpine induced hypothermia and potentiation of yohimbine toxicity, the effect of clenbuterol was greater following chronic treatment.

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Action De Medicaments Psychotropes Sur Un Test De Comportement Chez La Souris (“Test De Tantale”)

Cited by 2 publications

References 0 publications

Psychopharmacological profile of clenbuterol

Psychopharmacological profile of clenbuterol

Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol

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