Action and Toxicity of Vitamin B6 Hydrochloride

Weigand, C. G.; Eckler, C. R.; Chen, K. K.

doi:10.3181/00379727-44-11384

Cited by 11 publications

(4 citation statements)

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“…Therefore development of B,-induced seizures masked or suppressed most of the NMDA-induced phenomena and seizure activity. Although the effects of low doses of B, transforming to a coenzyme pyridoxalphosphate are well known, there is still no explanation for the proconvulsant effects of high doses (48,49). Recent studies suggest a direct interaction of high doses of B, with the GABA, receptor (50) or decreasing GABA content (5 1).…”

Section: Histologic Findingsmentioning

confidence: 99%

Age‐Specific N‐Methyl‐D‐Aspartate—Induced Seizures: Perspectives for the West Syndrome Model

et al. 1999

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Summary: Purpose: With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mgikg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder.Methods: Experiments were performed in 12-, 18-, and 60-day-old (adult) rats. The effects of systemic pretreatment with hydrocortisone (5-25 mg/kg), pyridoxine (20-250 mgkg), and sodium valproate (VPA; 200 and 400 mg/kg) against the NMDA-induced automatisms, emprosthotonic (hyperflexion), and clonic-tonic seizures were determined. NMDA-induced EEG changes and alterations of the performance in horizontal bar, rotorod, open field, and elevated plus-maze tests were recorded.Results: In young rats, hydrocortisone had proconvulsant effects. High doses of pyridoxine induced epileptiform activity independent of and distinct from that induced by NMDA. Only VPA had moderate effects against the NMDA-induced syndrome. EEG consisted of periods of suppression mixed with ictal activity of serrated waves and high-voltage chaotic EEG activity. In adult rats, EEG alterations involved spike and spike-and-wave activity. NMDA also deteriorated performance of young rats in the open field, rotorod, and elevated plus maze tests.Conclusions: NMDA syndrome in rats fulfills some, but not all, criteria of the West syndrome model, such as occurrence of flexion seizures, nonspecific diffuse EEG changes, refractoriness to antiepileptic therapy (but a response to VPA), as well as long-term alteration of behavioral tasks. However, NMDAinduced seizures represent an acute model without the occurrence of spontaneous seizures, whereas in the clinical situation, both the seizures and neurologic deterioration are chronic. Further, in the West syndrome and the NMDA seizure model, there is an incongruent response to therapy with antiepileptic drugs.

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Section: Histologic Findingsmentioning

confidence: 99%

Age‐Specific N‐Methyl‐D‐Aspartate—Induced Seizures: Perspectives for the West Syndrome Model

et al. 1999

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“…When Erabi et al, (1983) injected PLP into the ventricular sinus of rats, the animals exhibited convulsions. Weigand et al, (1940) administered single intravenous doses of 300 to 700 mg of PN·HCl/kg of BW to mice or rats. They reported mortality in mice with doses higher than 300 mg/kg and in rats with doses higher than 500 mg/kg.…”

Section: Hypervitaminosismentioning

confidence: 99%

Vitamin Tolerance of Animals

1987

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Download hundreds of free books in PDF • Read thousands of books online for free • Explore our innovative research tools -try the "Research Dashboard" now! • Sign up to be notified when new books are published • Purchase printed books and selected PDF files Thank you for downloading this PDF. If you have comments, questions or just want more information about the books published by the National Academies Press, you may contact our customer service department tollfree at 888-624-8373, visit us online, or send an email to feedback@nap.edu. This book plus thousands more are available at http://www.nap.edu.

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“…Vitamin B6 in high doses may cause neurological complications such as ataxia and severe peripheral sensory nervous system dysfunction. In a study of toxicity of vitamin B6 in mice, no clinical or pathological changes have been observed following intravenous injection of 100 mg/kg/day of vitamin B6 for 14 days [32].…”

mentioning

confidence: 99%

Retraction：Pretreatment of Cats with Vitamin B6 Reduces Vomiting Episodes Following Xylazine Administration

Jarolmasjed

2012

J. Vet. Med. Sci.

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Vomiting is a common problem of administration of xylazine in cats. This study was conducted to evaluate prophylactic antiemetic efficacy of vitamin B6 in sedated cats with xylazine. Eight adult cats were administered with intramuscular injection of normal saline or four increasing dosages of vitamin B6 an hour prior to administration of xylazine with one week intervals. All the cats were monitored after injection of xylazine for thirty min to record the onset of first emesis, frequency of emetic episodes and the onset of recumbency. Frequency of emetic episodes significantly decreased with each mentioned dosage of vitamin B6. This study showed that pretreatment of cats with vitamin B6 may reduce episodes of xylazine induced emesis without compromising its sedative effect.

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Action and Toxicity of Vitamin B6 Hydrochloride

Cited by 11 publications

References 0 publications

Age‐Specific N‐Methyl‐D‐Aspartate—Induced Seizures: Perspectives for the West Syndrome Model

Age‐Specific N‐Methyl‐D‐Aspartate—Induced Seizures: Perspectives for the West Syndrome Model

Vitamin Tolerance of Animals

Retraction：Pretreatment of Cats with Vitamin B6 Reduces Vomiting Episodes Following Xylazine Administration

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