Action and object naming in frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration.

Cotelli, Maria; Borroni, Barbara; Manenti, Rosa; Alberici, Antonella; Calabria, Marco; Agosti, Chiara; Arévalo, Analía; Ginex, Valeria; Ortelli, Paola; Binetti, Giuliano; Zanetti, Orazio; Padovani, Alessandro; Cappa, Stefano F.

doi:10.1037/0894-4105.20.5.558

Cited by 195 publications

(123 citation statements)

References 34 publications

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“…Disease and inferior-frontal lesions (Bak et al 2001;Bak and Hodges 2003;Boulenger et al 2008;Cotelli et al 2006;Tranel et al 2003); there is also patient data where a link between motor lesions and action language seems to be absent (Kemmerer et al 2012;Kalénine et al 2009;Arevalo et al 2012;Papeo et al 2010). More generally, postulating exclusive reliance on any one modal brain area would not be warranted by most theoretical approaches, including the simulation theory.…”

Section: Discussionmentioning

confidence: 99%

Primary motor cortex functionally contributes to language comprehension: An online rTMS study

et al. 2017

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ABSTRACT:Among various questions pertinent to grounding human cognitive functions in a neurobiological substrate, the association between language and motor brain structures is a particularly debated one in neuroscience and psychology. While many studies support a broadly distributed model of language and semantics grounded, among other things, in the general modality-specific systems, theories disagree as to whether motor and sensory cortex activity observed during language processing is functional or epiphenomenal. Here, we assessed the role of motor areas in linguistic processing by investigating the responses of 28 healthy volunteers to different word types in semantic and lexical decision tasks, following repetitive transcranial magnetic stimulation (rTMS) of primary motor cortex. We found that early rTMS (delivered within 200 ms of word onset) produces a left-lateralised and meaning-specific change in reaction speed, slowing down behavioural responses to action-related words, and facilitating abstract words -an effect present only during semantic, but not lexical, decision. We interpret these data in light of action-perception theory of language, bolstering the claim that motor cortical areas play a functional role in language comprehension.2

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Section: Discussionmentioning

confidence: 99%

Primary motor cortex functionally contributes to language comprehension: An online rTMS study

et al. 2017

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“…Unlike the other Indo-European languages considered, Chinese lacks explicit word-class contrasts in its grammatical morphology, which suggests that neural noun-verb dissociations may be influenced by structural properties of the individual's native language. [57,58] (for further discussion of the model, see [48,59] [13,15], amyotrophic lateral sclerosis [14,60], corticobasal degeneration [61,62], and frontotemporal dementia [63,64]. This evidence A classic ACE (compatible facilitation and incompatible delay of RTs) was observed for controls, but no ACE was observed in early PD participants.…”

Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 93%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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In recent years, the disruption of non-motor functions in motor disease has emerged as a promising topic for both basic and translational neuroscience. Impairments of movement and cognition were long regarded as separate phenomena [1]. However, a growing body of evidence indicates that neurodegenerative motor disorders also involve high-order cognitive dysfunctions, ranging from working memory, attention, and executive processing deficits [2][3][4], to impairments of language [4][5][6][7][8][9][10] and action knowledge [11]. Further data comes from studies showing that the same genes (e.g., C9orf72) are involved in diseases once perceived as purely motor or purely cognitive, such as motor neuron disease (MND) and frontotemporal dementia, respectively [12].A cognitive domain which seems to be specifically compromised in motor diseases is action language, that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs Words in moTion: moTor-lAnguAge couPling in PArkinson's diseAse Abstract A growing body of evidence indicates that neurodegenerative motor disorders involved high-order cognitive dysfunctions. Crucially, evidence obtained in multiple behavioral, neuroimaging, and electrophysiological studies points to selective impairments of action language -that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs (e.g., clap). Action-verb deficits (with relative preservation of noun processing) have been repeatedly documented in Parkinson's disease (PD). However, research on relevant biomarkers is still scant, and clinical implications of these findings have not yet been formally discussed. Relevant insights may be obtained through the assessment of motor-language coupling (i.e., the behavioral and neural integration of action-verb processing and ongoing motor actions). We propose that motorlanguage coupling deficits, as indexed by a cortical-subcortical network, may constitute an early neurocognitive marker of PD. Specifically, deficits in this domain at the prodromal stage may be detected through the actionsentence compatibility (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and action-verb processing. Our translational proposal is supported and illustrated by recent studies demonstrating the sensitivity of the ACE technique as well as its potential to assist in differential diagnosis and interventionprogram design.

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“…Behavioral and psychiatric disturbances were evaluated by Frontal Behavioral Inventory (FBI) (27). Patients with mild or moderate cognitive decline (MMSE ‡ 18) underwent extensive cognitive assessment, as described elsewhere (data not shown) (28). Patients with potentially confounding neurological and psychiatric disorders, clinically known hearing or vision impairment, a past history of alcohol abuse, psychosis, or major depression, were excluded from the study.…”

Section: Patients and Participantsmentioning

confidence: 99%