Actinomycosis of eye: Forgotten but not uncommon

Mehrotra, Neha; Baidya, Ankita; Brijwal, Megha; Aggarwal, Rita; Chaudhry, Rama

doi:10.1016/j.anaerobe.2015.06.001

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…Such infections originate from infected adjacent tissues or, less frequently, following hematogenous dissemination. Infections of the urogenital tract 19 , eye [20][21][22] , skin, and disseminated disease 23,24 focalized in the central nervous system (CNS) 25 are rare; a case of chronic lymphadenitis has also been reported 26 . Only vertical transmission has been reported, and two cases of neonatal sepsis have been described: one caused by A. neuii and the other (species unidentified) with uterine cerclage as the identifiable risk factor 27,28 .…”

Section: Introductionmentioning

confidence: 99%

Actinomycosis, a lurking threat: a report of 11 cases and literature review

Paulo

Jordão

Pinto

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Actinomycosis remains characteristically uncommon, but is still an important cause of morbidity. Its clinical presentation is usually indolent and chronic as slow growing masses that can evolve into fistulae, and for that reason are frequently underdiagnosed. Actinomyces spp is often disregarded clinically and is classified as a colonizing microorganism. In this review of literature, we concomitantly present 11 cases of actinomycosis with different localizations, diagnosed at a tertiary hospital between 2009 and 2016. We outline the findings of at least one factor of immunosuppression in > 90% of the reported cases.

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Section: Introductionmentioning

confidence: 99%

Actinomycosis, a lurking threat: a report of 11 cases and literature review

Paulo

Jordão

Pinto

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…5 It is estimated that these pathogens can reach the lacrimal system either directly or indirectly through contaminated oral secretions. 15 Furthermore, Actinomyces species are often isolated concomitantly with other normal aerobic and/or anaerobic commensals, among which members of Streptococcus genus are the most commonly associated organisms. 16 This is in accordance with our findings that polymicrobial infections were present in half of cases, mostly with Streptococcus species.…”

Section: Discussionmentioning

confidence: 99%

Actinomycotic primary canaliculitis: Predisposing factors, clinical characteristics, and treatment outcomes

Ding

Zhang

Feng

et al. 2023

European Journal of Ophthalmology

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Objective Ocular actinomycosis is an uncommon progressive infection. The study aims to investigate the predisposing factors, clinical characteristics and treatment outcomes of culture-proven cases of Actinomycotic primary canaliculitis. Methods Single-center, retrospective, interventional case series. Culture-proven cases of Actinomyces-associated primary canaliculitis diagnosed and treated between January 2017 and December 2021 at the Beijing Tongren Eye Center, Capital Medical University were identified and reviewed for ocular and systemic risk factors, clinical presentations, microbiological profile, treatment modalities and outcomes. Results Of the 201 patients diagnosed with primary canaliculitis, 22 (10.9%) were caused by Actinomyces. The mean age at onset of 22 patients (21 women and one men) was 54 years. The lower canaliculus was most commonly involved (54.6%). The most frequent symptom was mattering without epiphora (77.3%) and clinical signs were punctal regurgitation of purulent discharge (100%) and expressible concretions (95.5%). Dry eye co-existed in 77.3% of patients, whereas no obvious systemic factors were found. Among 19 cases (86.0%) of identified Actinomyces species, A. odontolyticus (43.5%) was the predominant causative microorganism. There were 50% of patients with polymicrobial infection and the most common additional bacteria isolated were Streptococcus species. Conservative therapy combining repeated canalicular expression and irrigation with susceptible topical antibiotics achieved complete resolution in 86.4% of patients. Conclusions Dry eye was identified in the vast majority of patients with Actinomycotic canaliculitis. Most cases are odontogenic in origin and the infection occurs in immunocompetent individuals. The conservative method combining canalicular expression and irrigation with topical susceptible antibiotics is recommendable as initial therapy.

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“…(Gram-positive cocci, corneal isolate), Actinomyces sp. (Gram-positive filamentous, corneal isolate), and Brevundimonas diminuta (Gram-negative bacillus, corneal isolate) have been reported as rare causes of ocular infections [ 276 , 277 , 278 ]. The isolates of Abiotrophia , Actinomyces , and Brevundimonas diminuta in our survey were all corneal isolates.…”

Section: Hapax Legomenon Isolatesmentioning

confidence: 99%

Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience

Astley,

Mursalin,

Coburn

et al. 2023

Microorganisms

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Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which bacteria are the likely cause of the infection. This survey of ocular bacterial isolates and review of ocular pathogens is based on a survey of a collection of isolates banked over a ten-year span at the Dean McGee Eye Institute in Oklahoma. These findings illustrate the diversity of bacteria isolated from the eye, ranging from common species to rare and unique species. At all sampled sites, staphylococci were the predominant bacteria isolated. Pseudomonads were the most common Gram-negative bacterial isolate, except in vitreous, where Serratia was the most common Gram-negative bacterial isolate. Here, we discuss the range of ocular infections that these species have been documented to cause and treatment options for these infections. Although a highly diverse spectrum of species has been isolated from the eye, the majority of infections are caused by Gram-positive species, and in most infections, empiric treatments are effective.

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Actinomycosis of eye: Forgotten but not uncommon

Cited by 10 publications

References 15 publications

Actinomycosis, a lurking threat: a report of 11 cases and literature review

Actinomycosis, a lurking threat: a report of 11 cases and literature review

Actinomycotic primary canaliculitis: Predisposing factors, clinical characteristics, and treatment outcomes

Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience

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