Actinomyces Neuii Endophthalmitis After Intravitreal Anti–vascular Endothelial Growth Factor Injection

Sahni, Sakshi; Watson, Randee Miller; Sheth, Veeral

doi:10.1097/icb.0000000000000345

Cited by 4 publications

(2 citation statements)

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“…It was the third most common diphtheroid and the most common Actinomyces species isolated from a tertiary center [36]. It has been reported in infected atheromas [37], abscesses [37], infected foreign bodies [2], urine [36] and endophthalmitis [38, 39]. There have been only a few case reports of classic actinomycosis caused by A. neuii .…”

Section: Discussionmentioning

confidence: 99%

Actinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review

Yang

Grant

2019

BMC Infect Dis

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Background Infective endocarditis caused by Actinomyces spp. is extremely rare. However, cases by new species of Actinomyces have been increasingly reported due to advances in laboratory techniques, and many of these species do not cause classic presentations of actinomycosis. Actinomyces neuii is reported to have a tendency to cause endovascular infection. The course of infective endocarditis caused by Actinomyces spp. is usually indolent. Case presentation A 61-year-old man with history of infective endocarditis, end stage renal disease, and monoclonal gammopathy was admitted for an abrupt fever, confusion, dysarthria, and facial droop after hemodialysis. Echocardiogram showed vegetations on both the aortic and mitral valves. Two sets of blood culture grew A. neuii . Brain MRI showed multiple bilateral cerebral infarcts consistent with septic emboli. The patient recovered after valvular surgery and prolonged intravenous and oral antibiotic therapy. Conclusions This case illustrates an unusually acute presentation of A. neuii infective endocarditis. As with other Gram-positive bacilli, Actinomyces spp. isolates are often regarded as a result of contamination. One should keep it in mind as a cause of infective endocarditis in vulnerable patient populations.

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Section: Discussionmentioning

confidence: 99%

Actinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review

Yang

Grant

2019

BMC Infect Dis

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“…Actinomyces neuii je stanovnik normalne mikroflore kože i sluzokože i to pogotovo oralne sluznice (kao i većina sojeva aktinomiceta i korinebakterija) [2]. Ipak, u studijama koje su uklјučene u ovaj sistematski pregledni članak pokazano je da A. neuii može izazvati endokarditis [9,17,22], endoftalmitis [8,26,28,29,30], osteomijelitis [15], pleuralni empijem [24], apsces [6,7,10,21], neonatalnu sepsu [14,23], peritonitis [18,27], infekcije ventrikuloperitonealnog šanta [13,19], infekcije periprostetičkog tkiva [16], infekcije proteze i okolnog tkiva [20,25].…”

Section: Slika 4 Antibiotici Korišćeni U Lečenju Infekcija Uzrokovanunclassified

Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review

Milentijević¹,

Katanic²,

Aritonović-Pribaković³

et al. 2020

Praxis medica

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Aims: The objectives of this study were to find out whether and to what extent Actinomyces neuii is pathogenic to humans in terms of causing invasive infections and to ascertain the most appropriate and effective antibiotic therapy against this bacterium. Material and method: This study was designed as a systematic review article. MEDLINE, Google Scholar, SCIndex, Cochrane database of published clinical trials - Central and Clinicaltrials.gov databases were systematically searched for primary case reports or case series describing invasive infection with Actinomyces neuii. Results: A literature search identified 23 studies that met the inclusion criteria, describing cases of patients with an invasive infection caused by Actinomyces neuii. It was found that A. neuii could cause endocarditis, endophthalmitis, osteomyelitis, pleural empyema, soft tissue abscesses, neonatal sepsis, ventriculoperitoneal shunt infections and periprosthetic tissue infections. The most prescribed antibiotics for the treatment of Actinomyces neuii infections were amoxicillin and vancomycin (n = 10; 12.3%), followed by penicillin (n =9; 11.1%), gentamicin (n = 6; 7.4%), ampicillin (n = 5; 6.2%) and ceftazidime (n = 4; 4.9%). Antibiotic treatment of infections caused by A. neuii was followed by clinical improvement or complete cure of all patients, with no recorded deaths. Conclusion: A. neuii has a relevant pathogenic potential to cause invasive infections of various organs and tissues, especially in immunocompromised individuals of any age. For the treatment of mild infections caused by this bacterium, the antibiotics of choice are penicillin or amoxicillin, while vancomycin should be used to treat severe infections caused by Actinomyces neuii.

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Aflibercept

2017

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Actinomyces Neuii Endophthalmitis After Intravitreal Anti–vascular Endothelial Growth Factor Injection

Abstract: This is the first published report of culture-positive endophthalmitis caused by A. neuii after intravitreal injection.

Cited by 4 publications

References 9 publications

Actinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review

Actinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review

Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review

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