Actinomyces-induced inflammatory myofibroblastic tumor of the colon: A rare cause of an abdominal mass

Akbulut, Sami; Yağmur, Yusuf; Gümüş, Serdar; Söğütçü, Nilgün; Demircan, Fırat

doi:10.1016/j.ijscr.2015.02.014

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…There are different theories regarding the etiology of IMTs including trauma, surgery, hemangioma hemorrhage or rupture, bacterial or viral infection, immune disorders and tumor processes[ 7 - 10 ]. Viruses, including HIV, human herpesvirus-8, and Epstein-Barr virus, are presumed to influence the development of IMT[ 11 - 14 ], and there is even a case report of secondary actinomycosis[ 15 ]. However, the actual pathogenesis remains unclear[ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the major component in microscopy, IMT is divided into three histopathological subtypes including xanthogranuloma type, plasma cell granuloma type and sclerosing pseudotumor[ 15 ]. Histologically, IMTs are characterized by spindle cells proliferating in a myxoid-to-collagen matrix with a prominent inflammatory infiltrate mainly composed of plasma cells and lymphocytes, and it is occasionally admixed with eosinophils and neutrophils.…”

Section: Discussionmentioning

confidence: 99%

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Hepatic inflammatory myofibroblastic tumor: A case report

Tong¹,

Zhang²,

Jia³

et al. 2023

World J Clin Cases

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BACKGROUND Hepatic inflammatory myofibroblastic tumor (HIMT) is a rare type of hepatic tumor. It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation, and its imaging findings are diverse. CASE SUMMARY Here, we report a case of HIMT that was initially diagnosed as liver malignancy but was confirmed as HIMT by histopathology after hepatectomy. Mostly, HIMTs are infiltrated with plasma cells and stain positively for anaplastic lymphoma kinase on immunohistochemistry as well as for some other kinases. CONCLUSION HIMT can be treated with single nonsteroidal anti-inflammatory drugs and without surgery when it is diagnosed accurately. Because the etiology of HIMT is unknown and the diagnosis is difficult, the pathogenesis and clinical process need to be further studied.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hepatic inflammatory myofibroblastic tumor: A case report

Tong¹,

Zhang²,

Jia³

et al. 2023

World J Clin Cases

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“…Actinomyces are usually extremely susceptible to beta-lactams. As for the antibiotic treatment of actinomycosis, penicillin G followed by oral penicillin or amoxicillin for up to 12 months are considered the drugs of choice [ 29 ], and other antibiotics such as erythromycin, clindamycin, or tetracycline can be given, especially in cases with penicillin allergy [ 30 ]. Drug resistance is not a problem in actinomycosis.…”

Section: Discussionmentioning

confidence: 99%

Abdominopelvic Actinomycosis—The Diagnostic and Therapeutic Challenge of the Most Misdiagnosed Disease

Vasilescu

Târcoveanu

Lupașcu

et al. 2022

Life

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Abdominopelvic actinomycosis is a rare chronic or subacute bacterial infection caused by Actinomyces israelii, a Gram-positive anaerobic bacterium that normally colonizes the digestive and genital tracts, clinically presented as an inflammatory mass or abscess formation. Methods: We reviewed the medical records of the patients from our clinic with abdominopelvic actinomycosis who underwent surgery between 2002 and 2022. In this period, 28 cases (9 men and 19 women) were treated. The mean age was 43.36 years and they were hospitalized for abdominopelvic tumors or inflammatory tumors in 15 cases and inflammatory disease in 13 cases. Results: Causes of actinomycosis in the studied group were an intra-uterine contraceptive device in 17 cases, foreign bodies in 2 cases, diabetes in 4 cases, stenting of the bile duct in 1 case, and immunodepression. For 6 patients, we performed surgery by open approach and for 21 patients by a laparoscopic approach. For nine patients, abdominopelvic actinomycosis had been mimicking a colon malignancy (cecum and ascending colon, four cases; transverse colon, two cases; and on the greater omentum, three cases) and for six patients, a pelvic tumor (advanced ovarian cancer). After surgery the patients underwent specific treatment with antibiotics, with good results. In two cases we discovered and treated hepatic actinomycosis, one case by a laparoscopic approach and one case by a percutaneous approach. In our lot we noticed three recurrences that required reintervention in patients who had had short-term antibiotics due to non-compliance with treatment out of four such cases. Conclusions: For abdominopelvic malignancies, actinomycosis should be included in the differential diagnosis, as well as for inflammatory bowel diseases and bowel obstructions. We have a wide range of patients considering the rarity of this condition. Long-term antibiotics are necessary to prevent recurrence.

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“…It was difficult to distinguish IPT with or without actinomycosis after the first biopsy because actinomycosis can exhibit local tissue invasion; IPT due to actinomycosis has also been reported ( 11 , 12 ). Second and third tumor biopsies were performed with an 18-G needle because we worried that the tumor samples obtained by the 21G needle had been insufficient to detect infection or malignancy.…”

Section: Discussionmentioning

confidence: 99%

Intratumor Abscess in a Posttraumatic Hepatic Inflammatory Pseudotumor Spreading Out of the Liver

et al. 2021

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A 45-year-old woman with abdominal pain after minor trauma was referred to our hospital. Computed tomography (CT) showed a hypovascular tumor in the left liver lobe. A tumor biopsy revealed granuloma, although no findings indicated malignancy or infection. A follow-up imaging study showed spread of the hepatic tumor. Her abdominal pain worsened after a second minor trauma. CT revealed an intratumor abscess, and pus overflowed from the patient's umbilicus. The abscess was improved by antibiotics and drainage therapy. In this case, unusual imaging findings and an atypical disease course of a hepatic inflammatory pseudotumor were observed.

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Actinomyces-induced inflammatory myofibroblastic tumor of the colon: A rare cause of an abdominal mass

Cited by 7 publications

References 9 publications

Hepatic inflammatory myofibroblastic tumor: A case report

Hepatic inflammatory myofibroblastic tumor: A case report

Abdominopelvic Actinomycosis—The Diagnostic and Therapeutic Challenge of the Most Misdiagnosed Disease

Intratumor Abscess in a Posttraumatic Hepatic Inflammatory Pseudotumor Spreading Out of the Liver

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