Actinomicetos con actividad anti-Candida aisladas de hormigas cortadoras de hojas Atta cephalotes (Formicidae: Myrmicinae: Attini)

Gutierrez-Espinoza, Cindy Abigail; Quispe, Jorge León

doi:10.17843/rpmesp.2018.354.3673

Cited by 2 publications

(3 citation statements)

References 20 publications

(23 reference statements)

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“…Additionally, they demonstrate strong inhibition effects on emerging Candida species such as C. glabrata and C. krusei with filipin II at concentrations of 0.9 and 1.4 µg ml −1 , respectively () [31]. Pronounced inhibitory activity against other emerging species such as C. parapsilosis was also exhibited by the family of bafilomycin C1 amide, 21-deoxybafilomycin A1 [82], and the compound HAA17, both derived from S. albidoflavus, although from different sources [83].…”

Section: Resultsmentioning

confidence: 99%

“…Leaf-cutting ants Atta cephalotes [83] RF fluconzaole-resistant; the superscript letters in the MIC values correspond to the species that was tested; the numbers in parentheses refer to the identification numbers given by the authors in the articles.…”

Section: S Albidoflavusmentioning

confidence: 99%

“…Amongst the compounds selected in review, some, such as the bafilomycin C1 [82] (Fig. 8), have a mechanism of action that disrupts the function of certain key cellular enzymes in Candida [83]. This disruption interferes with essential metabolic processes critical for the survival of the pathogen, ultimately leading to the inhibition of Candida growth and proliferation [97].…”

Section: S Albidoflavusmentioning

confidence: 99%

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Streptomyces: a natural source of anti-Candida agents

Martins,

Rodrigues da Silva,

Ratcliffe

et al. 2023

Journal of Medical Microbiology

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Introduction. There is an urgent need to source new compounds that can combat the current threat of serious infection caused by Candida spp. and contend with the problem of antimicrobial resistance. Gap. A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics. Aim. To highlight anti-Candida compounds derived from Streptomyces spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice. Methodology. A comprehensive review was conducted across three scientific literature databases spanning a 13-year period. Results. We identified 151 compounds with anti-Candida activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against Candida spp. of <3.5 µg ml−1, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti-Candida compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against Candida glabrata and Candida krusei, and bafilomycin derivatives, which had substantial inhibition against Candida parapsilosis. Conclusion. It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity, in vivo effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from Streptomyces , which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.

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Section: Resultsmentioning

confidence: 99%

Section: S Albidoflavusmentioning

confidence: 99%

Section: S Albidoflavusmentioning

confidence: 99%

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Streptomyces: a natural source of anti-Candida agents

Martins,

Rodrigues da Silva,

Ratcliffe

et al. 2023

Journal of Medical Microbiology

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Biorremediación de carbamazepina por hongos y bacterias en aguas residuales

Morales

Méndez

2021

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La carbamazepina (CBZ), un fármaco psiquiátrico, antiepiléptico; mayormente utilizado en la actualidad para tratar enfermedades como la epilepsia y neuralgia del trigémino; es un contaminante emergente, considerado como una fuente importante de contaminación de fuentes hídricas, al no ser totalmente metabolizado por el organismo y ser excretado por vía urinaria y fecal, sin cambios o en forma de metabolitos conjugados. Estos contaminantes pasan por tratamientos de aguas residuales, sin embargo, los tratamientos convencionales no son capaces de degradarlo, produciendo daños a los seres vivos que habitan y necesitan de este recurso natural para poder sobrevivir. Frente a este problema, el objetivo de esta revisión fue identificar tratamientos biológicos con la utilización de microorganismos (bacterias y hongos) para la degradación de este compuesto recalcitrante. Los microorganismos identificados con mayor porcentaje de degradación de carbamazepina fueron Labrys portucalensis F11 y Trametes versicolor; la primera una bacteria que se adapta a diferentes fuentes de carbono; y el segundo un hongo denominado de pudrición de la madera, que presenta enzimas oxidativas que le permiten degradar una amplia gama de contaminantes emergentes. Trametes versicolor, es el microorganismo mayormente estudiado para los procesos de degradación de carbamazepina, con porcentajes de degradación de hasta el 94% a una temperatura de 25°C y un pH de 4.5.

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Actinomicetos con actividad anti-Candida aisladas de hormigas cortadoras de hojas Atta cephalotes (Formicidae: Myrmicinae: Attini)

Cited by 2 publications

References 20 publications

Streptomyces: a natural source of anti-Candida agents

Streptomyces: a natural source of anti-Candida agents

Biorremediación de carbamazepina por hongos y bacterias en aguas residuales

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