Actinomadura pelletieri mycetoma – an atypical case with spine and abdominal wall involvement

Mandraffino, Giuseppe; Cinquegrani, Maurizio; Delfino, Demetrio; Mandraffino, R.; Romeo, Orazio; Criseo, Giuseppe; Saitta, Antonino

doi:10.1099/jmm.0.027862-0

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…He had a chronic right shoulder focus that progressed to infiltrate the soft tissue of the right neck and compress the cervical cord. Similarly, sacral spinal compression from extensive actinomycotic abdominal disease has been reported by Cascio et al [29] . Also, a review of thoracic vertebral actinomycosis identified only 14 reported previous cases from 1951 to 2007.…”

Section: Discussionsupporting

confidence: 59%

See 1 more Smart Citation

Dot-in-circle sign in cervical actinomycotic mycetoma: An extremely rare case report

Abera,

Dumessa,

Robele

et al. 2024

Radiology Case Reports

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Section: Discussionsupporting

confidence: 59%

“…Alternatives such as clindamycin, tetracycline, and erythromycin are used in penicillin-allergic patients. Generally, prolonged treatment (6-12 months) is necessary to eradicate the infection and prevent recurrence [ 14 , [26] , [27] , [28] , [29] , [30] , [31] ]. The exact duration is tailored based on clinical response.…”

Section: Discussionmentioning

confidence: 99%

Dot-in-circle sign in cervical actinomycotic mycetoma: An extremely rare case report

Abera,

Dumessa,

Robele

et al. 2024

Radiology Case Reports

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“…4 Among them were Actinomadura madurae, Actinomadura pelletieri, Actinomadura latina and A. palatopharyngis are associated with human disease. [5][6][7][8][9][10][11] "Actinomadura geliboluensis" + "pulmonary actinomycosis" or "patient" or "human" were used as the search terms, and the search language was Chinese or English. No reports of…”

Section: Discussionmentioning

confidence: 99%

A Rare Strain Actinomadura geliboluensis Was First Isolated from the Bronchoalveolar Lavage Fluid of a Patient with Pneumonia

Yang¹,

Yang²,

Wang³

et al. 2023

IDR

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Background Actinomadura geliboluensis was first isolated in 2012 in Gelibolu, Canakkale, Turkey, and has not been reported to be isolated from humans until now. We have isolated it from the bronchoalveolar lavage fluid (BLF) of a patient with pneumonia and found its drug resistance. It is the first time that Actinomadura geliboluensis has been isolated from humans since its discovery and naming. This case may provide new ideas and methods for the clinical diagnosis and treatment of pulmonary actinomycosis. Case Description The patient was a 75-year-old male who was hospitalized in a township hospital and failed to improve after penicillin treatment. After admission to our hospital, the patient was treated with piperacillin/tazobactam according to clinical guidelines for 14 days. Actinomadura geliboluensis was isolated from the patient’s BLF and was identified by 16S rRNA sequencing. This report shows the biological characteristics and in vitro drug susceptibility testing, as well as the genomics analysis based on next-generation sequencing (NGS). The results demonstrated that Actinomadura geliboluensis was easy to be mistakenly identified as Actinomyces dental caries by using the Merieux ANC identification card. Based on the MIC test, Actinomadura geliboluensis was susceptible to tetracyclines, quinolones and sulfonamides, but resistant to carbapenems, penicillins and cephalosporins. The K-B test results showed Actinomadura geliboluensis was highly sensitive to piperacillin/tazobactam. Genomic analysis based on NGS showed that the Actinomadura geliboluensis belongs to Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A, AAC(3)-VIIa, vanRO, chrB , and mexY . Conclusion Actinomycetes is generally sensitive to Penicillin but Actinomadura geliboluensis is not. In vitro drug susceptibility test is needed to support individualized drug use to avoid delay in the disease.

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“…are reported to be associated with infections in humans, commonly in tropical and subtropical regions of the world. The major infections include mycetoma by Actinomadura madurae (De Palma et al, 2006) and Actinomadura pelletieri (Cascio et al, 2011), pulmonary infection by Actinomadura sputi (Yassin et al, 2010), and osteitis by Actinomadura meyerae (Bonnet et al, 2011). Additionally, Actinomadura spp.…”

Section: Introductionmentioning

confidence: 99%

Actinomadura Species: Laboratory Maintenance and Ribosome Engineering

et al. 2017

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Actinomadura spp. are aerobic, Gram-positive, catalase-positive, non-acid fast, non-motile actinomycetes. Some species of Actinomadura are associated with opportunistic infections in humans. However, many bioactive compounds with pharmaceutical applications can be isolated from various Actinomadura spp. This unit includes general protocols for the laboratory maintenance of Actinomadura spp., including growth in liquid medium, growth on solid agar, long-term storage, and generation of a higher producing strain by ribosome engineering. Actinomadura hibisca P157-2 is used as a prototype for explaining the considerations for efficient laboratory maintenance of Actinomadura spp. © 2017 by John Wiley & Sons, Inc.

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Actinomadura pelletieri mycetoma – an atypical case with spine and abdominal wall involvement

Cited by 10 publications

References 7 publications

Dot-in-circle sign in cervical actinomycotic mycetoma: An extremely rare case report

Dot-in-circle sign in cervical actinomycotic mycetoma: An extremely rare case report

A Rare Strain Actinomadura geliboluensis Was First Isolated from the Bronchoalveolar Lavage Fluid of a Patient with Pneumonia

Actinomadura Species: Laboratory Maintenance and Ribosome Engineering

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