Actinobacillus hominis as a causative agent of septicemia in hepatic failure

Wüst, J; Gubler, Jacques; Mannheim, W.; Graevenitz, A. von

doi:10.1007/bf01975828

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that A. hominis has been described from bacteremias in Switzerland (12), Germany (12), and France (the present study) and has been isolated from respiratory tract specimens from Greenland, Sweden, and the Czech Republic indicates that the geographic dissemination of the microorganisms is widespread. A tradition for extensive characterization of small gram-negative rods in this country is probably part of the explanation for the predominance of the Danish isolates.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Clinical Significance and Taxonomy ofActinobacillus hominis

Friis-Møller

Christensen²,

Fussing

et al. 2001

J Clin Microbiol

View full text Add to dashboard Cite

Clinical findings in 36 immunosuppressed patients with lower respiratory tract infection or bacteremia withActinobacillus hominis are described. Animal contact was only recorded for three patients; nine patients died despite appropriate antimicrobial treatment. Although infections with this microorganism seem to be rare, the fact that 37 of 46 strains characterized in this study have been found in Copenhagen indicates that underreporting may occur. A. hominis is phenotypically relatively homogeneous but can be difficult to differentiate from other Actinobacillus species unless extensive biochemical testing is performed. Mannose-positive strains of A. hominis are especially difficult to differentiate from A. equuli. Attempts to identify A. hominis by automatic identification systems may lead to misidentifications. Ribotyping and DNA-DNA hybridization data show that A. hominis is a homogeneous species clearly separated from other species within the genus Actinobacillus.The genus Actinobacillus is comprised of species that are animal pathogens, the only exceptions being Actinobacillus ureae and Actinobacillus hominis, which appear to be highly adapted to humans. A. ureae was first described as a human respiratory tract pathogen in 1960 (8). In 1981, Friis-Møller reported on 17 cases of respiratory tract infections with an "A. ureae-like" bacterium, which was classified as a distinct species, A. hominis (5). Since then, only a few reports of diseases caused by this microorganism have been reported in the literature; these have, however, involved invasive disease (6, 12).Since we now have a collection of 46 A. hominis strains isolated from various European countries, including blood culture isolates, we report here on clinical findings from patients infected with this microorganism. Furthermore, we investigate strain variability within A. hominis and describe its relationship to closely related species of the family Pasteurellaceae as determined by conventional methods, ribotyping, and DNA-DNA hybridization, and we examine the accuracy of commercial identification systems in this area. MATERIALS AND METHODSStrains. The 46 A. hominis isolates examined in the present study are listed in Table 1. Thirty-eight isolates from 37 patients (one patient had A. hominis isolated twice from the sputum with an interval of 15 months) were found in Copenhagen at five different departments of clinical microbiology from 1977 to 1999. There were two isolates each from Greenland, Germany, and France and one each from the Czech Republic and Sweden. The majority of isolates were found in the respiratory tract (sputa and tracheal and bronchial secretions), one was from the pleural fluid, and four were from blood. Selected strains were studied for DNA-DNA hybridization levels and were characterized by automatic identification systems (vide infra). Twenty type and reference strains from taxa related to A. hominis and used for comparison in the bacteriological study are listed in Table 2. Of these, only the Haemophilus species and A. ureae a...

show abstract

Section: Discussionmentioning

confidence: 52%

“…A case of pleural empyema with A. hominis in a patient with carcinoma was published in 1988 (6). Finally, in 1991 Wüst et al (12) reported two cases of bacteremia with A. hominis in patients with hepatic failure and a history of drug and alcohol abuse. Both patients died despite appropriate antimicrobial treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance and Taxonomy ofActinobacillus hominis

Friis-Møller

Christensen²,

Fussing

et al. 2001

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

Pasteurella,Mannheimia,Actinobacillus,Eikenella,Kingella,Capnocytophaga, and Other Miscellaneous Gram-Negative Rods

Janda¹,

Mutters²

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

View full text Add to dashboard Cite

Actinobacillus

Olsen¹,

Möller²

2015

Bergey's Manual of Systematics of Archaea and Bacteria

View full text Add to dashboard Cite

Ac.ti.no.ba.cil' lus . Gr. n. actis a ray; L. dim. masc. n. bacillus a small staff or rod; M.L. masc. n. Actinobacillus ray bacillus or rod. Proteobacteria / Gammaproteobacteria / Pasteurellales / Pasteurellaceae / Actinobacillus Cells, measuring 0.4 ± 0.1 × 1.0 ± 0.4 µm, are spherical, oval, or rod‐shaped (Phillips, 1984). Most often bacillary but sometimes interspersed with coccal elements that may lie at the pole of a larger form, producing the characteristic “ Morse‐code ” form . Cell forms up to 6 µm in length may appear when grown on media containing glucose or maltose. Cells are single or arranged in pairs or, more rarely, in chains. Endospores are not formed. Gram negative, but staining is irregular. Not acid fast. India ink may demonstrate small amounts of extracellular slime in wet preparations. Nonmotile . Organisms are aerobic, microaerobic, facultatively anaerobic, or chemoorganotrophic, having both respiratory and fermentative types of metabolism. After growth for 24 h on blood agar, translucent colonies, usually 1–2 mm in diameter appear. Surface colonies have low viability and may die in 2–7 days. Growth may be very sticky upon primary cultivation, making it difficult to remove colonies completely from the agar surface. Optimum growth temperature is 37°C. Temperature range for growth is 25–42°C. The mol % G + C of the DNA is : 35.5–46.9. Type species : Actinobacillus lignieresii Brumpt 1910, 849.

show abstract

Actinobacillus hominis as a causative agent of septicemia in hepatic failure

Cited by 6 publications

References 5 publications

Clinical Significance and Taxonomy ofActinobacillus hominis

Clinical Significance and Taxonomy ofActinobacillus hominis

Pasteurella,Mannheimia,Actinobacillus,Eikenella,Kingella,Capnocytophaga, and Other Miscellaneous Gram-Negative Rods

Actinobacillus

Contact Info

Product

Resources

About