Actinin‐4 controls survival signaling in B cells by limiting the lateral mobility of B‐cell antigen receptors
Saed Alsouri,
Ashley Ambrose,
Nikolaos Mougios
et al.
Abstract:The structure and dynamics of F‐actin networks in the cortical area of B cells control the signal efficiency of B‐cell antigen receptors (BCRs). Although antigen‐induced signaling has been studied extensively, the role of cortical F‐actin in antigen‐independent tonic BCR signaling is less well understood. Because these signals are essential for the survival of B cells and are consequently exploited by several B‐cell lymphomas, we assessed how the cortical F‐actin structure influences tonic BCR signal transduct… Show more
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