Actinic prurigo

Scheen, S. Randy; Connolly, Suzanne M.; Dicken, Charles H.

doi:10.1016/s0190-9622(81)70086-0

Cited by 32 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Covered areas were also affected in 8 of our patients (72%). This concurred with previous reports elsewhere (2,6,15,16). Only 2 patients (18%) had cheilitis.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

The clinical features and management of actinic prurigo: a retrospective study

Lestarini

Khoo

Goh

1999

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

Actinic prurigo (AP) is a rare photodermatosis, mostly affecting young American Indian girls. A retrospective descriptive study was done in the National Skin Centre, Singapore. Our patients have different characteristics compared to the previous reports. Of the 11 cases found between 1990 and 1998, 10 were male. All of the patients had the onset in adulthood. The condition was recognised by the presence of papules and nodules on the sun-exposed areas, predominantly on forearms and back of hands. Phototests revealed lowered minimal erythemal dose (MED) to ultraviolet A (UVA) alone in 2 patients and lowered MED to both UVA and UVB in another 4 patients. Patch, photopatch and histological examination did not show any significant finding. Sun protection, emollients and topical steroid were the baseline treatment for all patients. Intralesional steroid, systemic steroid, psoralen plus ultraviolet A (PUVA), azathioprine and thalidomide were used in some patients, with variable results.

show abstract

“…Covered areas were also affected in 8 of our patients (72%). This concurred with previous reports elsewhere (2,6,15,16). Only 2 patients (18%) had cheilitis.…”

Section: Discussionsupporting

confidence: 93%

“…Actinic prurigo (AP) is reported as a rare familial photodermatosis which mostly affects young girls (1)(2)(3). AP was previously considered as a unique variant of polymorphic light eruption (PMLE), but recently it has been described as a different entity, which has characteristic geographic and racial distribution, as well as genetic susceptibility (4).…”

mentioning

confidence: 99%

The clinical features and management of actinic prurigo: a retrospective study

Lestarini

Khoo

Goh

1999

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

show abstract

“…Characteristic clinical features include prurigo-like papules, cheilitis and conjunctivitis with pseudopterigium formation. However, pruritus is the predominant symptom which is usually noted at early phases of the disease [19]. AP is often refractory to therapy, although topical, intralesional or systemic steroids [6], psoralen plus ultraviolet A [20], azathioprine [2], cyclosporine [8]and thalidomide [9]have been used with variable results.…”

Section: Commentmentioning

confidence: 99%

Pentoxifylline in the Treatment of Actinic Prurigo

Torres-Álvarez¹,

Castanedo-Cázares²,

Moncada³

2004

Dermatology

View full text Add to dashboard Cite

Background: Actinic prurigo (AP) is a chronic familial photodermatosis usually seen in Latin-American Mestizo and Indian populations. It frequently begins in childhood and is more prevalent in females. The pathogenesis of AP has not been clearly elucidated, but previous studies have suggested an immune-mediated condition. Many drugs have been employed to treat AP patients with variable success. Objective: To assess the clinical efficacy of pentoxifylline (PTX) in the treatment of AP patients by measuring its effects on lesions and pruritus. Methods: 10 patients with severe AP were included to receive PTX in a 6-month open-label uncontrolled study. Results: Clinical improvement of lesions was evident in all patients. Relief in pruritus was evident after 1 month of treatment and was maintained while receiving PTX. Five patients were followed up for 2 years, 2 obtained complete remission, and 3 had an important reduction in the use of corticosteroids. Conclusion: PTX was useful in the treatment of our actinic prurigo patients. It may induce a complete or partial remission of lesions and allow a decrease in the use of topical corticosteroids.

show abstract

“…In our experience, the use of antimalarial drugs on a seasonal basis combined with monitoring for adverse effects was considered for recalcitrant cases, but was rarely of much clinical benefit. The prescription of β‐carotene as a photoprotective agent has also had limited success 21,24 . The use in low doses compared with previous reports 21,24 may account for its lack of success as a photoprotective agent in this series.…”

Section: Discussionmentioning

confidence: 84%

Actinic prurigo: A retrospective analysis of 21 cases referred to an Australian photobiology clinic

2002

View full text Add to dashboard Cite

Actinic prurigo (AP) is a rare acquired idiopathic photodermatosis, reported most often in American Indians, but also in Caucasian and Asian populations. The skin lesions in AP predominantly affect exposed sites but may involve covered areas, and often result in postinflammatory scarring. The diagnosis of AP can be difficult and relies on a combination of history, clinical experience and investigations including phototesting and human leucocyte antigen typing. Twenty-one patients (17 women, four men) diagnosed with AP at the photobiology clinic at St Vincent's Hospital Melbourne were reviewed in this retrospective study. The mean age of patients at presentation to the clinic was 25 years, with the mean age of onset being 14 years. Phototesting was undertaken in 20 patients, with 12 (60%) having reduced and eight (40%) normal minimal erythema doses. Human leucocyte antigen typing indicated 18 patients (85.7%) were DR4 positive, with further subtyping of the DR4 allele establishing that 15 patients (71.4%) were DRB1*0407 positive and that two (9.5%) were DRB1*0401 positive. This condition is often recalcitrant, with treatment options including photoprotection, topical and oral corticosteroids, antimalarials, phototherapy and thalidomide.

show abstract

Actinic prurigo

Cited by 32 publications

References 13 publications

The clinical features and management of actinic prurigo: a retrospective study

The clinical features and management of actinic prurigo: a retrospective study

Pentoxifylline in the Treatment of Actinic Prurigo

Actinic prurigo: A retrospective analysis of 21 cases referred to an Australian photobiology clinic

Contact Info

Product

Resources

About