Actinic keratosis – state of art. Statement of experts of Polish Dermatological Society

Włodarkiewicz, Adam; Adamski, Zygmunt; Chodorowska, Grażyna; Kaszuba, Andrzej; Reich, Adam; Szepietowski, Jacek C.

doi:10.5114/dr.2014.42831

Cited by 2 publications

(2 citation statements)

References 85 publications

(101 reference statements)

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“…The epidermal architectural and cytological features of AK were investigated including: epidermal thickness, hyper- and parakeratosis, hypercellularity, loss of stratification, abnormal keratinocyte maturation, presence and level of cellular atypia, namely enlarged, hyperchromatic, irregular nuclei and mitoses. Three AK classification stages – KIN1, KIN2, and KIN3 – were used in the histopathological evaluation [9].…”

Section: Methodsmentioning

confidence: 99%

“…The highest prevalence has been reported in Australia: 79% and 68% of males and females aged 60–69, respectively, but only 10% of men and 5% of women aged 20–29 years, respectively, indicating that the disease is sex and age-related [4, 5]. Prolonged exposure to ultraviolet radiation (UV) – mainly UVB, which has the highest carcinogenic potential, as well as pale skin phenotype – typical for the Caucasian race, play the key roles in the etiopathogenesis of AK [6–9].…”

Section: Introductionmentioning

confidence: 99%

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Cyclooxygenase-2 expression in actinic keratosis

Adamska

Pawlaczyk

Bowszyc‐Dmochowska

et al. 2018

pdia

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A b s t r a c tIntroduction: Actinic keratosis (AK) is a common age-associated dermatosis typical for skin with photo-ageing features. Actinic keratosis lesions transform into invasive squamous cell carcinoma, if left untreated, but inductive factors remain unknown. A role of prostaglandins in the neoplastic process has been postulated. Aim: To evaluate the possible correlation between cyclooxygenase-2 (COX-2) antigen expression in the immunohistochemical reaction and the stage of AK using the keratinocytic intraepidermal neoplasia (KIN) classification, age, sex and skin phenotype. Material and methods: Skin samples of AK were examined histopathologically using the KIN classification. Immunohistochemical analysis of COX-2 expression was conducted using a commercially available kit and Image Processing and Analysis in Java. The intensity was presented as the percentage of cells with a positive reaction. Results: Out of the 94 subjects with AK (aged 51-93 years; mean: 76.51 ±9.64), 58 were female and 36 male. Phenotype 2 was found in 50 and phenotype 3 in 44 patients. Mean values of positive immunohistochemical reaction for COX-2 were 2.16 ±6.56% for women and 1.96 ±6.59% for men (2.47 ±6.61%), with no statistically significant difference. Mean values of anti-COX-2 antibody reaction were 2.30 ±6.82% in the KIN1 group and 2.48 ±7.01% in the KIN2 group, while no expression was found in all cases with KIN3. No statistically significant differences were found between the percentage of COX-2 positive cells in KIN1/KIN2. Conclusions: No statistically significant correlations between the intensity of COX-2 reaction and AK stage were found. Cyclooxygenase-2 expression in AK is not affected by age, sex, or skin phenotype.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cyclooxygenase-2 expression in actinic keratosis

Adamska

Pawlaczyk

Bowszyc‐Dmochowska

et al. 2018

pdia

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The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT’s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT’s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

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Actinic keratosis – state of art. Statement of experts of Polish Dermatological Society

Cited by 2 publications

References 85 publications

Cyclooxygenase-2 expression in actinic keratosis

Cyclooxygenase-2 expression in actinic keratosis

The use of photodynamic therapy in medical practice

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