Actinic keratosis in the<i>en-face</i>and slice imaging mode of high-definition optical coherence tomography and comparison with histology

Maier, Tanja; Braun‐Falco, Markus; Laubender, Rüdiger P.; Ruzicka, Thomas; Berking, Carola

doi:10.1111/j.1365-2133.2012.11202.x

Cited by 49 publications

(72 citation statements)

References 24 publications

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“…Imaging techniques such as OCT and RCM have been applied for various indications, including non-melanoma and melanocytic skin cancer [12,13,14]. Also, inflammatory reactions such as contact or allergic eczema and infestations with parasites have been studied using these techniques [15,16].…”

Section: Discussionmentioning

confidence: 99%

Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography

Bielicky

Braun‐Falco²,

Ruzicka³

et al. 2015

Dermatology

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Aquagenic wrinkling of the palms (AWP) is a rare condition, which is characterized by appearance of whitish papules and plaques, and an excessive wrinkling and swelling of the palmar skin after exposure to water. In most cases, young women are affected, and an association of AWP with cystic fibrosis (CF) has been surmised. We report on two cases of AWP, which were not related to CF, in whom we used two innovative imaging techniques, namely high-definition optical coherence tomography and reflectance confocal microscopy, to show in vivo skin changes occurring after exposure of the skin to tap water in comparison to the findings in a healthy control person.

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Section: Discussionmentioning

confidence: 99%

Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography

Bielicky

Braun‐Falco²,

Ruzicka³

et al. 2015

Dermatology

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“…Thus, field cancerization is defined as an area of subclinical changes in the periphery of visible AKs that displays the same genetic changes found in the lesion itself . New imaging techniques, such as reflectance confocal microscopy (RCM) and high‐definition optical coherence tomography (HD‐OCT), which allow visualization of the photodamage surrounding AKs, confirm that the disease often affects the entire sun‐exposed field (Fig. ) …”

Section: Field Cancerization Of the Skinmentioning

confidence: 99%

The importance of treating the field in actinic keratosis

Stockfleth

2017

Acad Dermatol Venereol

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Actinic keratoses (AKs) are intraepithelial atypical proliferations of keratinocytes that develop in skin that has undergone long-term exposure to ultraviolet radiation. Given the ageing population and an increasing prevalence of AK, the socioeconomic burden of AK is likely to rise over the coming years. Areas of subclinical (non-visible) sun damage in the periphery of visible AK lesions contain the same genetic changes as those found in the lesions themselves, and are known as areas of field cancerization. AK lesions and the field are associated with an increased risk of skin cancer, including invasive squamous cell carcinoma. Although effective in clearing visible AK, lesion-directed therapies do not address field cancerization and can lead to high recurrence rates. In contrast, field-directed therapies, such as ingenol mebutate, imiquimod and diclofenac, can clear both visible and subclinical AK lesions and reduce the development of new lesions in the treated field. Additionally, preclinical studies suggest that field therapy may prevent or delay the recurrence of non-melanoma skin cancer. AK treatment guidelines now recognize the importance of treating the field in patients with AK, and adaptation of treatment guidelines into clinical practice is warranted. Physician and patient education around the consequences of leaving the field of cancerization untreated is necessary in order to reduce the increasing burden associated with AK.

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“…Various studies have investigated characteristics of sun damage and skin cancer in OCT, and their correlation with histological entities. In particular, it has been demonstrated that NMSC as actinic keratosis (AK), squamous cell carcinoma (SCC) and BCC have shown distinct features in OCT …”

Section: Introductionmentioning

confidence: 99%

Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

Wahrlich

Alawi

Batz

et al. 2015

Acad Dermatol Venereol

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Multi-beam optical coherence tomography revealed to be a fast and promising device for assessing lesions by means of BS. Both students, who benefit from practice in handling OCT, and experts are able to perform this procedure. However, experience and training in the interpretation markedly increased sensitivity and specificity of the BS in our study. Moreover, redefinition and refining of the criteria seems necessary and may further increase the diagnostic value of OCT for NMSC.

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Actinic keratosis in theen-faceand slice imaging mode of high-definition optical coherence tomography and comparison with histology

Cited by 49 publications

References 24 publications

Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography

Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography

The importance of treating the field in actinic keratosis

Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

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