Actinic keratosis

Oral acetylsalicylic acid and prevalence of actinic keratosis

“…Besides its potential (0.6-20%) for turning into invasive neoplasms, they reflect the accumulated photodamage and indicate a larger risk of developing skin cancers in every region affected by the disease. [1][2][3][4][5] They are common in sun-exposed areas of elderly fairskinned people, representing 5.1% of complaints in dermatological consultations in Brazil. In Australia, it is estimated that 40-50% of the population above 40 years of age presents at least one lesion.…”

Actinic Keratosis and Squamous Cell Carcinoma

“…Some studies have suggested that actinic keratosis is in situ intradermal squamous cell carcinoma, which in 10% of the case can develop into SCC. [2] The management of actinic keratosis is difficult as it is difficult to clearly distinguish actinic keratosis from squamous cell carcinoma. As such it is essential for clinicians to obtain histopathological information when unable to clearly identify the nature of a lesion.…”

“…[6] Risk factors for the development of actinic keratosis include, fair skin or light pigmentation status, caucasian individuals, freckles, light colored eyes (blue or green), blonde or red hair, male gender, older age, severe baldness, skin wrinkling and increased sun exposure due to outdoor occupation/activity. [2,7] Actinic keratosis presents as a rough, itchy and scaly lesion that can occur singly but usually grows as multiple dry, fleshy colored, erythematous papules or plaques with telangiectasia, that are usually covered in brown or yellow adherent scales. [2] The distribution of actinic keratosis depends on a number of factors such as ethnicity, socioeconomic status, age, skin type, occupation, sex, and birth place.…”

“…[2,7] Actinic keratosis presents as a rough, itchy and scaly lesion that can occur singly but usually grows as multiple dry, fleshy colored, erythematous papules or plaques with telangiectasia, that are usually covered in brown or yellow adherent scales. [2] The distribution of actinic keratosis depends on a number of factors such as ethnicity, socioeconomic status, age, skin type, occupation, sex, and birth place.…”

Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio

“…Os raios UVB promovem alterações genéticas que podem provocar mutações no gene epitelial supressor de tumor, p53, induzindo a desregulação das suas funções, permitindo assim que os queratinócitos alterados consigam prosseguir e propagar-se. Ao continuarem sofrendo exposição aos raios UVB, esses queratinócitos instáveis genomicamente, estão susceptíveis às alterações genéticas e moleculares adicionais que podem desencadear o processo de malignização (LEFFELL, 2000;ACKERMAN;MONES, 2006;HORTA et al, 2007;ROSSI;MOR;LOTT, 2007;WOOD et al, 2011).…”