Actinic granuloma. A clinical, histopathologic, and immunocytochemical study

Annular Elastolytic Giant Cell Granuloma Occurring in Covered Areas

“…However, considering the fact that phagocytosis of elastic materials does occur regardless of the presence of solar elastosis, we support the possibility of the latter. McGrae [13] postulated a cell-mediated immune response; however, additional stu dies would be required to determine whether AEGCG is a sort of transient autoimmune disease (generally healing spontaneously within a few years).…”

Elastolytic Actinic Giant Cell Granuloma

“…McGrae 8 suggested an immune response mediated by cells to degenerated elastic tissue, with a predominance of helper T cells in the lymphocytic infiltrate. He also observed differences between the enzymes of the histiocytes of AG and those of GA, 8 supporting that these are different conditions. Elastin peptides are responsible for inducing factor XIIIa(1) cells and macrophages to form granulomas and multinucleated giant cells.…”

“…Other investigators supported O'Brien's 2 concept of AG as a distinct entity. [7][8][9][10] Cases showing characteristics of both GA and EAGCG have been also reported. 11 The descriptive term annular elastolytic giant cell granuloma was proposed by Hanke and colleagues 12 for lesions identical to AG but located not only in sun-exposed skin.…”

Annular elastolytic giant cell granuloma of conjunctiva: A case report

“…[1] It almost always occurs on sun exposed skin, such as face, neck, dorsum of hand, forearm, and arm and hence the previous name actinic granuloma; however there are few reports occurring in sun-protected sites. A possibly related process occurs on the conjunctiva.…”