Actin Polymerization Status Regulates Tendon Homeostasis through Myocardin-Related Transcription Factor-A
Valerie C. West,
Kaelyn Owen,
Kameron L. Inguito
et al.
Abstract:The actin cytoskeleton is a potent regulator of tenocyte homeostasis. However, the mechanisms by which actin regulates tendon homeostasis are not entirely known. This study examined the regulation of tenocyte molecule expression by actin polymerization via the globular (G-) actin-binding transcription factor, myocardin-related transcription factor-a (MRTF). We determined that decreasing the proportion of G-actin in tenocytes by treatment with TGFβ1 increases nuclear MRTF. These alterations in actin polymerizat… Show more
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