Actin Isoform Composition and Binding Factors Fine-Tune Regulatory Impact of Mical Enzymes
Jose L. Martin,
Aaqil Khan,
Elena E. Grintsevich
Abstract:Mical family enzymes are unusual actin regulators that prime filaments (F-actin) for disassembly via the site-specific oxidation of M44/M47. Filamentous actin acts as a substrate of Mical enzymes, as well as an activator of their NADPH oxidase activity, which leads to hydrogen peroxide generation. Mical enzymes are required for cytokinesis, muscle and heart development, dendritic pruning, and axonal guidance, among other processes. Thus, it is critical to understand how this family of actin regulators function… Show more
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