Actin Filaments in Contracting Preretinal Membranes

Wallow, Ingolf H. L.; Stevens, Thomas S.; Greaser, Marion L.; Bindley, Colleen D.; Wilson, Robin S.

doi:10.1001/archopht.1984.01040031112036

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…Several cell types, such as astrocytes, fibrocytes, hyalocytes, macrophages, and retinal pigment epithelial cells, can be found in epiretinal membrane, [21][22][23][24] and many of them have the ability to develop myofibroblast characteristics. 25 When this event occurs, contraction of the membrane may cause macular distortion, axoplasmic stasis, and macular edema of variable amount.…”

Section: Baselinementioning

confidence: 46%

Assessment of Macular Function by Focal Electroretinogram and Pattern Electroretinogram Before and After Epimacular Membrane Surgery

Parisi

Coppé

Gallinaro

et al. 2007

Retina

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Section: Baselinementioning

confidence: 46%

Assessment of Macular Function by Focal Electroretinogram and Pattern Electroretinogram Before and After Epimacular Membrane Surgery

Parisi

Coppé

Gallinaro

et al. 2007

Retina

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“…Morphologically, mesenchymal (spindle/fibrous) cells comprise a variable proportion of cells within PIFMs and should be vimentin positive 1 . Myofibroblasts (identified by smooth muscle actin expression) have also been identified in intraocular neovascular membranes in other species and may cause contraction of PIFMs and secondary distortion of the iris profile 5,28,29 …”

Section: Introductionmentioning

confidence: 99%

Canine pre-iridal fibrovascular membranes: morphologic and immunohistochemical investigations

Zarfoss

Breaux

Whiteley

et al. 2010

Veterinary Ophthalmology

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“…In eyes with EMM, the several factors (e.g., incomplete posterior vitreous detachment) may induce cell proliferation in retinal inner limiting membrane. In EMM different cell types such as astrocytes, fibrocytes, macrophages, hyalocytes were found [ 12 , 13 ] and some of them have characteristics of myofibroblasts [ 14 ]. The consequences of these events are macular distortion and/or macular edema and axoplasmic stasis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of macular function, structure and predictive value of pattern electroretinogram parameters for postoperative visual acuity in patients with idiopathic epimacular membrane

et al. 2016

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PurposeTo evaluate macular function and structure before and after epimacular membrane surgery and to estimate the usefulness of pattern ERG test parameters in predicting the postoperative visual acuity.MethodsWe evaluated 32 eyes of 32 patients (mean age 70.8 ± 6.7 years) before and 12 months after successful 25G pars plana vitrectomy with epimacular membrane removal and internal limiting membrane peeling. Distance best-corrected visual acuity (DBCVA—logMAR), foveal thickness (optical coherence tomography—OCT) and macular function [pattern electroretinogram—PERG (ISCEV standard): amplitudes (A) of P50- and N95-waves, implicit time (IT) of P50-wave] were assessed. To estimate the differences between the mean values of considered characteristics, the t test or Wilcoxon matched pair test was used. Correlation between preoperative data of PERG and preoperative and final DBCVA were investigated using Pearson correlation analysis. A receiver operating characteristic curve was constructed to obtain a cutoff value allowing prediction of visual prognosis. We tried to obtain the P50 and N95 amplitudes cutoff value in prediction of good visual outcome (DBCVA of 0.3 or less).ResultsTwelve months after surgery, mean of DBCVA significantly increased in comparison with preoperative value (0.31 ± 0.12 vs. 0.6 ± 0.15; p < 0.001) and 23/32 eyes (72 %) achieved visual improvement of two and more Snellen lines. In OCT test, the significant reduction in foveal thickness mean (313.34 ± 47.01 vs. 509.03 ± 93.88 µm; p < 0.001) was obtained. In PERG test, the significant increase in the mean amplitudes of P50- (AP50) and N95 (AN95)-waves as well as significant decrease in the mean implicit time (IT) of P50-wave were achieved (AP50: 3.41 ± 1.48 vs. 2.38 ± 1.23 µV; p < 0.001; AN95: 5.46 ± 1.72 vs. 3.75 ± 1.48 µV; p < 0.001; IT P50: 55.00 ± 3.60 vs. 56.75 ± 5.78 ms; p < 0.001). Twelve months postoperatively, DBCVA was significantly correlated with preoperative IT P50 (r = 0.39; p = 0.027), AP50 (r = −0.68; p < 0.001) and AN95 (r = −0.73; p < 0.001).ConclusionRemoval of idiopathic epimacular membranes with internal limiting membrane peeling not only provided increase in visual acuity and reduction in foveal thickness but also caused improvement of innermost retinal layer function in macular region. Pattern ERG test might be a valuable tool in predicting the postoperative visual acuity.

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Actin Filaments in Contracting Preretinal Membranes

Cited by 14 publications

References 12 publications

Assessment of Macular Function by Focal Electroretinogram and Pattern Electroretinogram Before and After Epimacular Membrane Surgery

Assessment of Macular Function by Focal Electroretinogram and Pattern Electroretinogram Before and After Epimacular Membrane Surgery

Canine pre-iridal fibrovascular membranes: morphologic and immunohistochemical investigations

Assessment of macular function, structure and predictive value of pattern electroretinogram parameters for postoperative visual acuity in patients with idiopathic epimacular membrane

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