“…This analysis revealed significant enrichment of, among others, genes involved in focal adhesion (Figure 1E). Among these were CFL1, a protein that depolymerizes F-actin and that, upon knockdown, was shown to enhance transinfection of HIV-1 between dendritic cells (DCs) and T lymphocytes (Ménager and Littman, 2016); CD99, which is involved in T cell adhesion and leukocyte migration (Bernard et al, 2000; Hahn et al, 1997; Sohn et al, 2001); and ATP1B1, which is a subunit of the Na + /K + transporter. These results suggest that Vpu-mediated immune evasion strategies may affect a broader range of host cell functions than previously appreciated, including host metabolic processes and plasma membrane activities.…”