Actin complexes in the cell nucleus: new stones in an old field

Castaño, Enrique; Philimonenko, Vlada; Kahle, Michal; Fukalová, Jana; Kalendová, Alžběta; Yıldırım, Serkan; Dzijak, Rastislav; Dingová-Krásna, H.; Hozák, Pavel

doi:10.1007/s00418-010-0701-2

Cited by 63 publications

(52 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the existence of nuclear actin was confirmed, subsequent studies also established the presence of ABPs in the nucleus (12,14,15). The very first nuclear ABP was reported as early as 1987, henceforth, the rest of the ABP family in the nucleus has come to light comprising of proflilin, anillin, flightless I (Fli I), filamin α (FLNα), α-actinins, myosins, gelsolin and ezrin-radixin-moesin proteins (12,13,16,17). Although these ABPs are primarily in the cytoplasm, they can translocate into the nucleus under certain circumstances, for example, extracellular stimuli (stress), hormone stimulation and intracellular signaling (16).…”

Section: Actin and Actin-binding Proteins (Abps) In The Nucleusmentioning

confidence: 90%

“…Studies in the recent decades provide a plethora of evidence that has broadened our horizon on the functions of nuclear actin and nuclear ABPs in the eukaryotic cell life (12)(13)(14). Since the existence of nuclear actin was confirmed, subsequent studies also established the presence of ABPs in the nucleus (12,14,15).…”

Section: Actin and Actin-binding Proteins (Abps) In The Nucleusmentioning

confidence: 99%

“…envelope assembly (12,(18)(19)(20). Nuclear ABPs are closely associated to nuclear actin and implicated in various nuclear activities.…”

Section: Functions Of Nuclear Actin-binding Proteins In Human Cancer mentioning

confidence: 99%

“…Nuclear actin and nuclear ABPs exhibit nuclear-specific functions that are different from those in the cytoplasm. Although the precise biological mechanisms remain elusive, we are fortunate to uncover several observations (12). This review aims to present up-to-date discoveries of nuclear actin and nuclear ABPs in the field of cancer research.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functions of nuclear actin-binding proteins in human cancer (Review)

Yang

2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Nuclear actin-binding proteins (ABPs) perform distinguishable functions compared with their cytoplasmic counterparts in extensive activities of living cells. In addition to the ability to regulate actin cytoskeleton dynamics, nuclear ABPs are associated with multiple nuclear biological processes, including chromatin remodeling, gene transcriptional regulation, DNA damage response, nucleocytoplasmic trafficking and nuclear structure maintenance. The nuclear translocation of ABPs is affected by numerous intracellular or extracellular stimuli, which may lead to developmental malformation, tumor initiation, tumor progression and metastasis. Abnormal expression of certain ABPs have been reported in different types of cancer. This review focuses on the newly identified roles of nuclear ABPs in the pathological processes associated with cancer.

show abstract

Section: Actin and Actin-binding Proteins (Abps) In The Nucleusmentioning

confidence: 90%

Section: Actin and Actin-binding Proteins (Abps) In The Nucleusmentioning

confidence: 99%

“…envelope assembly (12,(18)(19)(20). Nuclear ABPs are closely associated to nuclear actin and implicated in various nuclear activities.…”

Section: Functions Of Nuclear Actin-binding Proteins In Human Cancer mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functions of nuclear actin-binding proteins in human cancer (Review)

Yang

2017

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…This large set of proteins has been involved in chromatin remodeling, transcription by all three RNA polymerases, DNA repair and RNA processing and translocation (Castano et al, 2010). The localization of FHOS in the nucleus of dying salivary glands raises a question on the role that formin may play in the nucleus.…”

Section: Fhos Is Localized Into the Nucleus In Dying Lsgsmentioning

confidence: 99%

Fhos encodes a Drosophila Formin‐Like Protein participating in autophagic programmed cell death

Anhezini

Saita

Costa

et al. 2012

Genesis

View full text Add to dashboard Cite

Summary: Larval tissues undergo programmed cell death (PCD) during Drosophila metamorphosis. PCD is triggered in a stage and tissue-specific fashion in response to ecdysone pulses. The understanding of how ecdysone induces the stage and tissue-specificity of cell death remains obscure. Several steroid-regulated primary response genes have been shown to act as key regulators of cellular responses to ecdysone by inducing a cascade of transcriptional regulation of late responsive genes. In this article, the authors identify Fhos as a gene that is required for Drosophila larval salivary gland destruction. Animals with a P-element mutation in Fhos possess persistent larval salivary glands, and precise excisions of this P-element insertion resulted in reversion of this salivary gland mutant phenotype. Fhos encodes the Drosophila homolog of mammalian Formin Fhos. Fhos is differentially transcribed during development and responds to ecdysone in a method that is similar to other cell death genes. Similarly to what has been shown for its mammalian counterpart, FHOS protein is translocated to the nucleus at later stages of cell death. Fhos mutants posses disrupted actin cytoskeleton dynamics in persistent salivary glands. Together, our data indicate that Fhos is a new ecdysone-regulated gene that is crucial for changes in the actin cytoskeleton during salivary gland elimination in Drosophila. genesis 50:672-684, 2012. V V C 2012 Wiley Periodicals, Inc.

show abstract

Effects of environmental stress factors on the actin cytoskeleton of fungi and plants: Ionizing radiation and ROS

Stephan

2023

Cytoskeleton

View full text Add to dashboard Cite

Actin is an abundant and multifaceted protein in eukaryotic cells that has been detected in the cytoplasm as well as in the nucleus. In cooperation with numerous interacting accessory‐proteins, monomeric actin (G‐actin) polymerizes into microfilaments (F‐actin) which constitute ubiquitous subcellular higher order structures. Considering the extensive spatial dimensions and multifunctionality of actin superarrays, the present study analyses the issue if and to what extent environmental stress factors, specifically ionizing radiation (IR) and reactive oxygen species (ROS), affect the cellular actin‐entity. In that context, this review particularly surveys IR‐response of fungi and plants. It examines in detail which actin‐related cellular constituents and molecular pathways are influenced by IR and related ROS. This comprehensive survey concludes that the general integrity of the total cellular actin cytoskeleton is a requirement for IR‐tolerance. Actin's functions in genome organization and nuclear events like chromatin remodeling, DNA‐repair, and transcription play a key role. Beyond that, it is highly significant that the macromolecular cytoplasmic and cortical actin‐frameworks are affected by IR as well. In response to IR, actin‐filament bundling proteins (fimbrins) are required to stabilize cables or patches. In addition, the actin‐associated factors mediating cellular polarity are essential for IR‐survivability. Moreover, it is concluded that a cellular homeostasis system comprising ROS, ROS‐scavengers, NADPH‐oxidases, and the actin cytoskeleton plays an essential role here. Consequently, besides the actin‐fraction which controls crucial genome‐integrity, also the portion which facilitates orderly cellular transport and polarized growth has to be maintained in order to survive IR.

show abstract

Actin complexes in the cell nucleus: new stones in an old field

Cited by 63 publications

References 176 publications

Functions of nuclear actin-binding proteins in human cancer (Review)

Functions of nuclear actin-binding proteins in human cancer (Review)

Fhos encodes a Drosophila Formin‐Like Protein participating in autophagic programmed cell death

Effects of environmental stress factors on the actin cytoskeleton of fungi and plants: Ionizing radiation and ROS

Contact Info

Product

Resources

About