Actin-binding carbon dots selectively target glioblastoma cells while sparing normal cells

Sharma, Anjana; Panwar, Vineeta; Thomas, Jijo; Chopra, Vianni; Roy, Himadri Shekhar; Ghosh, Deepa

doi:10.1016/j.colsurfb.2021.111572

Cited by 18 publications

(13 citation statements)

References 63 publications

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“…Antibacterial spermidine was used to produce CDs 77 . Curcumin was also employed in CDs synthesis 78 , 79 . Tryptophan based CDs were prepared for the delivery of drugs to the brain 80 .…”

Section: Design Of Carbon Dots From Low Molecular Weight (Lmw) Organi...mentioning

confidence: 99%

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A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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“…Antibacterial spermidine was used to produce CDs 77 . Curcumin was also employed in CDs synthesis 78 , 79 . Tryptophan based CDs were prepared for the delivery of drugs to the brain 80 .…”

Section: Design Of Carbon Dots From Low Molecular Weight (Lmw) Organi...mentioning

confidence: 99%

“…However, CurCDs showed better selectivity towards C6 cells, as proven by the significantly lower toxicity toward HDF cells. The CDs were able to induce the death of the glioma cells by apoptosis 79 . Therefore, the CDs derived from curcumin provided the additional advantage of enhanced specificity.…”

Section: Cytotoxic Carbon Dots From Pure Organic Compoundsmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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“…The molecules were tested for cytocompatibility using a macrophages cell line (RAW 264.7) [44] and human dermal fibroblasts (HDF). [45] In brief, the respective cells were seeded in 96 well plate at a cell density of 15,000 cells/well and 3000 cells/well and incubated for 24 h in Dulbecco's modified Eagle's medium (DMEM) and then treated with various concentrations of test molecules for 24 h at 37 °C in 5 % CO 2 incubator. The cell viability was checked by MTT.…”

Section: Cytocompatibility Assaymentioning

confidence: 99%

Efficient Nitric Oxide Scavenging by Urea‐Functionalized Push‐Pull Chromophore Modulates NO‐Mediated Diseases

Roy¹,

Neethu²,

Rajput

et al. 2023

Chemistry A European J

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The excess nitric oxide (NO) produced in the body in response to bacterial/proinflammatory stimuli is responsible for several pathological conditions. The current approaches that target the production of excess NO, either through the inhibition of nitric oxide synthase enzyme or its downstream mediators have been clinically unsuccessful. With an aim to regulate the excess NO, we developed urea‐functionalized push‐pull chromophores containing 1,1,4,4‐tetracyanobuta‐1,3‐dienes (TCBD) or expanded TCBD (eTCBD) as NO scavengers. The NMR mechanistic studies revealed that upon NO binding, these molecules are converted to uncommon stable NONOates. The unique emissive property of Urea‐eTCBD enables its application in vitro, as aNO‐sensor. Furthermore, the cytocompatible Urea‐eTCBD, rapidly inactivated the NO released from LPS‐activated cells. The therapeutic efficacy of the molecule in modulating NO‐mediated pathological condition was confirmed using a carrageenan‐induced inflammatory paw model and a corneal injury model. While the results confirm the advantages of scavenging the excess NO to address a multitude of NO‐mediated diseases, the promising sensing and bioactivity of Urea‐eTCBD can motivate further exploration of such molecules in allied areas of research.

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“…Still new studies are needed to select specific targets on GBM cells and to select possible new transporters to functionalize the NPs. Recent research has studied, in this regard, the use of curcumin conjugated to CDs [56].…”

Section: Carbon Nanomaterials and Brain Tumorsmentioning

confidence: 99%

Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas

Caffo¹,

Curcio²,

Caruso³

et al. 2022

Preprint

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Malignant gliomas are the most common primary brain tumors in adults up to an extent of 78% of all primary malignant brain tumors. However, total surgical resection is almost unachievable due to considerable infiltrative ability of glial cells. The efficacy of current multimodal therapeutic strategies is, furthermore, limited by the lack of specific therapies against malignant cells, and, therefore, the prognosis these in patients is still very unfavorable. The limitation of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent to brain tumors are major reasons for this unsolved clinical problem. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents. Nanoparticles, thanks to their chemical configuration, are able to go through the blood-brain barrier carrying drugs or genes targeted against gliomas. Carbon nanomaterials show distinct properties including electronic properties, penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs. In this review we will focus on the potential effectiveness of the use of carbon nanomaterials in the treatment of malignant gliomas discussing the current progress of in vitro and in vivo researches of carbon nanomaterials-based drug delivery to brain.

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Actin-binding carbon dots selectively target glioblastoma cells while sparing normal cells

Cited by 18 publications

References 63 publications

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Efficient Nitric Oxide Scavenging by Urea‐Functionalized Push‐Pull Chromophore Modulates NO‐Mediated Diseases

Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas

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