Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb
Salla Kyheröinen,
Bina Prajapati,
Maria Sokolova
et al.
Abstract:Nuclear actin has been demonstrated to be essential for optimal transcription, but the molecular mechanisms and direct binding partner for actin in the RNA polymerase complex have remained unknown. By using purified proteins in a variety of biochemical assays, we demonstrate a direct and specific interaction between monomeric actin and Cdk9, the kinase subunit of the positive transcription elongation factor b (P-TEFb) required for RNA polymerase II pause-release. This interaction efficiently prevents actin pol… Show more
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