Actin as a Possible Cross-Reactive Allergen Between Fish and Poultry

Barbarroja-Escudero, J.; Sánchez-González, M.J.; Bartolomé, Borja; Pastor-Vargas, Carlos; Rodríguez-Rodríguez, M.; Cuesta‐Herranz, Javier; Álvarez‐Mon, Melchor

doi:10.18176/jiaci.0357

Cited by 5 publications

(7 citation statements)

References 7 publications

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“…Other allergens Barbarroja-Escudero et al studied the serum of a woman referred for recurrent anaphylaxis to fish and who subsequently developed anaphylaxis to chicken and turkey. The authors discovered cross-reactive allergens of 33 and 42 kDa; the latter was identified as α-actin [25]. This allergen was previously reported in a case of allergy to Nile perch [51].…”

Section: Et Al Demonstrated That Parvalbumin Could Be Detected In Var...mentioning

confidence: 84%

Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes

Wanniang

Codreanu‐Morel

Kuehn

et al. 2022

Curr Treat Options Allergy

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Purpose of review In the recent years, more cases of poultry meat allergy, both IgE- or non-IgE-mediated, are being reported. Patients have varied clinical reactivity at various levels of sensitivity to different meat preparations. The lack of validated biomarkers renders accurate diagnosis challenging. In this review, we aim to provide an overview of the current status of poultry meat allergy along with a description on the allergens implicated. Recent findings Poultry meat allergy occurs as a result of cross-reactions with known allergens of egg yolk or bird feathers or as genuine IgE-mediated sensitivity to allergens in poultry meat. Individuals can also develop non-IgE-mediated hypersensitivity reactions to poultry meat. Chicken serum albumin is the main responsible allergen in secondary cases, while myosin light chain, α parvalbumin, enolase, aldolase, hemoglobin, and α-actin have been recognized as potential eliciting allergens in genuine poultry meat allergy. Summary There is a wide phenotypic variation among patients with poultry meat allergy, regarding clinical severity and cross-reactivity features. Recognizing the various clinical entities of reactions to poultry meat is an important step towards accurate diagnosis and providing management options that are well received by patients.

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Section: Et Al Demonstrated That Parvalbumin Could Be Detected In Var...mentioning

confidence: 84%

Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes

Wanniang

Codreanu‐Morel

Kuehn

et al. 2022

Curr Treat Options Allergy

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“…Spot no 6 was identified as actin, which is an essential component of cell cytoskeleton and participates in many important cellular processes, including cell motility, cell division, various plant cell signalling events etc. Actin was earlier reported as a major allergen from molluscs ( Mohamad-Yadzir et al., 2015 ; Azofra et al., 2017 ; González-Mancebo et al., 2019 ), which is recently reported as a cross-reactive allergen ( Barbarroja-Escudero et al., 2019 ). However, no report was available on the allergenic nature of this protein of plant origin.…”

Section: Discussionmentioning

confidence: 97%

Allergenicity assessment of Delonix regia pollen grain and identification of allergens by immunoproteomic approach

Bhowmik

Ghosh

Bhattacharya

2021

Heliyon

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Background: Plantation of roadside avenue trees has become a major part of urbanization programme for megacity beautification and environmental management. Due to evergreen habit and vibrant flower colour, Delonix regia (Gulmohor/Flamboyant) is frequently selected as ornamental tree for plantation programme. However, D. regia pollen is related to IgE mediated allergic reactions and no allergen has been reported so far. Objective: Measuring the prevalence of D. regia pollen sensitivity among the local atopic individuals and identifying the allergens using immunoproteomic tools. Methods: Aerobiological study was conducted for a period of two years to record the D. regia pollen concentration in the outdoor ambient air. Clinico-immunological tests were performed on atopic individuals to check the prevalence of sensitivity against D. regia pollen. Allergens were detected in the pollen proteome, fractionated in 1D and 2D gel by IgE serology and finally identified by mass spectrometry. Result: In the study area D. regia pollen grains were present in ample amount in the air during May to July. About 38% of atopic individuals displayed positive Skin Prick Test (SPT) against D. regia pollen along with elevated level of specific IgE and histamine in the sera. Immunoproteomic analyses revealed the presence of 14 IgE reactive proteins in the 2D pollen proteome, of which 8 IgE reactive proteins were identified by MALDI TOF/TOF using homology driven proteomic approach. Conclusion: This study demonstrated pollen related allergy symptoms by D. regia and gave significant message regarding the plantation programme to avoid the unnecessary load of allergic pollen. Also, a panel of 8 allergens were identified for the first time from D. regia pollen. Detailed study of these allergens would help to design immunotherapeutic strategies for pollinosis management.

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“…In a case of cross-reactivity between fish and chicken, Barbarroja-Escudero et al noted that actin may be a cross-allergen in fish and poultry. 67 Furthermore, Lefevre et al described a case of an allergic reaction after consuming caviar and affirmed by immunoblotting that the patient was allergic to a 26 kDa protein in caviar. 68 Tropomyosin, a common allergen in crustaceans, was detected as a fish allergen by a fish-specific monoclonal antibody.…”

Section: Enolase and Aldolasementioning

confidence: 97%

“…Apart from the above-mentioned allergens of fish, other allergens are also present as cross-allergens in fish and other species. In a case of cross-reactivity between fish and chicken, Barbarroja-Escudero et al noted that actin may be a cross-allergen in fish and poultry . Furthermore, Lefèvre et al described a case of an allergic reaction after consuming caviar and affirmed by immunoblotting that the patient was allergic to a 26 kDa protein in caviar .…”

Section: Fish Allergensmentioning

confidence: 99%

Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

Sun,

Luo,

Chen

et al. 2024

ACS Food Sci. Technol.

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Fish is one of eight foods that can cause severe allergic reactions. The growing consumption of fish and fish derivatives contributes to an increase in the incidence of fish allergies. Distinct regional variations in fish allergies are evident with higher prevalence rates observed in coastal countries, which may be related to the high consumption of local fish in these regions. The diagnostic methods of fish allergies include in vivo and in vitro detection, and the skin prick test is one of the most common screening methods. To date, several fish allergens have been identified, including parvalbumin, enolase, aldolase, collagen, and other allergens. Despite the homologous structure of parvalbumin from different fish species, variations in the IgE epitope may be one of the reasons leading to the complexity of fish allergies. To further understand the mechanisms of fish allergies, this review summarizes the recent literature and focuses on the clinical characteristics, mechanism, allergens, epitopes, and cross-reactivity.

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Actin as a Possible Cross-Reactive Allergen Between Fish and Poultry

Cited by 5 publications

References 7 publications

Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes

Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes

Allergenicity assessment of Delonix regia pollen grain and identification of allergens by immunoproteomic approach

Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

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