Actigraphy-based sleep characteristics and aortic stiffness: the Multi-Ethnic Study of Atherosclerosis

Abstract

Objective: The study aimed to examine the association based on objective estimates of sleep duration and quality and aortic stiffness while accounting for the potential confounding effect of SDB. Method: Participants were part of the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep study. Sleep duration and quality were assessed by 7-day wrist actigraphy, SDB by home polysomnography, and aortic stiffness by magnetic resonance imaging (MRI)-based aortic pulse wave velocity (aPWV), ascending and descending aorta distensibility (AAD and DAD). Aortic stiffness of participants with ‘normal’ sleep duration (6–8 hours) were compared with those of ‘short’ (<6 hours) and ‘long’ sleep duration (>8 hours) adjusting for common cardiovascular risk factors and apnea hypopnea index (AHI). Results: The sample consisted of 908 participants (mean age 68.4±9.1 years, 55.3% female). There was a significant linear trend of increased aPWV across short (n=252), normal (n=552), and long sleep durations (n=104) (p for trend=0.008). Multivariable analysis showed that people with short sleep duration had 0.94 m/s lower aPWV (95% CI: −1.54, −0.35), compared with those with normal sleep duration. Conclusion: In this ethnically diverse community cohort, habitual short sleep duration as estimated by actigraphy was associated with lower aortic stiffness.

Visit‐to‐visit blood pressure variability and sleep architecture

“…Abnormal sleep duration and poor quality (eg, low sleep efficiency and obstructive sleep apnea [OSA]) can contribute to disturbed BP control and cardiovascular risks, such as hypertension. 9,10 Sleep nographic data from 3,565 patients referred to an academic sleep center. BPV was calculated using the intra-individual coefficient of variation of BP measures collected 12 months before the sleep study.…”

“…Sleep also plays an essential role in cardiovascular health. Abnormal sleep duration and poor quality (eg, low sleep efficiency and obstructive sleep apnea [OSA]) can contribute to disturbed BP control and cardiovascular risks, such as hypertension 9,10 . Sleep architecture is an objective measure of sleep quality assessed by polysomnography (PSG).…”

“…Abnormal sleep duration and poor quality (eg, low sleep efficiency and obstructive sleep apnea [OSA]) can contribute to disturbed BP control and cardiovascular risks, such as hypertension. 9,10 Sleep architecture is an objective measure of sleep quality assessed by polysomnography (PSG). This parameter characterizes the distributions of different stages, and it can be broadly classified into two forms: rapid eye movement (REM) and non-rapid eye movement including N1, N2, and N3 stages (collectively NREM).…”

Sleep Apnea and Heart

“…While this U-shaped has generally been advocated, the relation is more complex. For example, objectively measured sleep duration had a positive linear relationship with arterial stiffness in the community-dwelling elderly population [97]. Furthermore, a meta-analysis on over 3 million participants demonstrated a J-shaped relationship between sleep duration and increased risk for mortality and incident CVD [98].…”

Irregularidade do sono e a associação com a hipertensão e níveis pressóricos: dados do estudo ELSA-Brasil

“…58,59 Critérios semelhantes foram usados por outros investigadores. 60 Calculamos o tempo de vigília após o início do sono (WASO), definido pelos períodos de vigília que ocorrem após o início do sono definido. A eficiência do sono foi definida pela proporção do tempo total de sono em relação ao tempo total na cama, sendo a menor eficiência do sono significando maior fragmentação do sono.…”