Actifit® synthetic meniscal substitute: Experience with 18 patients in Brest, France

Baynat, C.; Andro, C.; Vincent, Jean-Claude; Schiele, P.; Buisson, P.; Dubrana, F.; Gunepin, François-Xavier

doi:10.1016/j.otsr.2014.09.007

Cited by 51 publications

(38 citation statements)

References 6 publications

(6 reference statements)

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“…No cases of scaffold separation or meniscal degeneration were recorded in one study, with 50% of patients being able to return to their sporting activities at the time of the two-year followup36). A failure rate of 17.3% was reported in a study assessing polyurethane scaffolds37).…”

Section: Resultsmentioning

confidence: 96%

“…It is also not well documented whether these meniscus-like scaffolds can transmit the load enough to prevent chondral wear. The main types of meniscal scaffold used were Actifit polyurethane meniscal scaffolds or CMI36,39–41,43,49). A phase II feasibility study in eight patients showed new fibrocartilage matrix formation on biopsy tissue and integration into the scaffold was seen on second-look arthroscopy30).…”

Section: Discussionmentioning

confidence: 99%

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Meniscal Transplants and Scaffolds: A Systematic Review of the Literature

Dangelmajer

Familiari

et al. 2017

Knee Surg Relat Res

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The reported incidence of meniscal tears is approximately 61 per 100,000. In instances where preservation of the native meniscus is no longer a feasible option, meniscal allograft transplantation (MAT) and implants or scaffolds may be considered. The goal of this review was to compare the success and failure rates of two techniques, MAT and meniscal scaffolds, and make an inference which treatment is more preferable at the present time and future. Studies that met inclusion criteria were assessed for technique used, type of transplant used, number of procedures included in the study, mean age of patients, mean follow-up time, number of failures, failure rate, and reported reoperation rate. Fifteen studies for the MAT group and 7 studies for the meniscal scaffold group were identified. In this selection of studies, the average failure rate in the MAT group was 18.7% and average reoperation rate was 31.3%. The average failure rate in the meniscal scaffold group was 5.6%, and average reoperation rate was 6.9%. It appears that although MAT is associated with high reoperation and failure rates, the limited number of studies on both MAT and scaffolds and mainly short-term results of scaffold studies make it difficult to make an objective comparison.

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Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Meniscal Transplants and Scaffolds: A Systematic Review of the Literature

Dangelmajer

Familiari

et al. 2017

Knee Surg Relat Res

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“…The available short-and long-term studies of clinical outcomes of MAT are variable and difficult to effectively compare due to the heterogeneity of the study population and the availability of treatment techniques 187 . Meniscal allograft transplantation yields fair to excellent results in almost 85% of patients; patients report a significant decrease in pain, as well as an increase in activity [188][189][190][191][192][193] . Meniscal allografts are associated with generally good clinical outcomes, in terms of minimizing radiographic changes, maintaining normal gait and exercise activity and promoting cellular incorporation and tissue healing 150,194 .…”

Section: Results Of Meniscal Transplantsmentioning

confidence: 99%

Meniscus tear surgery and meniscus replacement

Vaquero

Forriol

2019

Muscle Ligaments and Tendons J

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Objective: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. Methodology: a search of the electronic medical literature database Medline was conducted, from http://www.ncbi.nlm.nih.gov/pubmed. The search was not limited by language. Candidate articles were identified by searching for those that included the keywords meniscus, surgery, suture, implant, allograft. The limits were included for clinical research and clinical trials. Basic research was not included. The studies selected were evaluated and classified in three different categories: basic science, reconstruction (suture and meniscectomy) and implants (scaffolds and allograft). Results: the consequences of meniscectomy performed at a young age can lead to a joint cartilage degeneration twenty years later. There are few surgical options for the repair of meniscal injuries in order both to preserve the meniscus and to ensure the long term survival of the knee joint, meniscectomy, repair, suturing the tear, or reconstruction, when a meniscal allograft or synthetic substitute is used to replace the meniscus, but the biomechanical properties of the native meniscus are not reproduced entirely by the scaffolds that exist today.Conclusion: therapies that successfully repair or replace the meniscus are therefore likely to prevent or delay osteoarthritis progression.

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“…The short-term clinical success of meniscus implantation is very high in these patient groups according to the literature. 10,38,42 However, these methods should be combined with additional procedures that promote healing to shorten the long recovery periods and reduce the problems that patients face when they return to sports. According to our study, CBMA injection in combination with meniscus implantation provides early significant improvement in clinical functions and rapid decrease in the level of pain in our patients.…”

Section: Discussionmentioning

confidence: 99%

Medial Meniscus Scaffold Implantation in Combination with Concentrated Bone Marrow Aspirate Injection: Minimum 3-Year Follow-up

et al. 2020

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AbstractThe objective of this study is to show the short-term clinical and radiological outcomes of concentrated bone marrow aspirate (CBMA) injection administered in combination with medial meniscus scaffold implantation. Twenty-three patients who received intra-articular CBMA injection in combination with polyurethane-based medial meniscus scaffold implantation were evaluated within the scope of this study. The International Knee Documentation Committee (IKDC) questionnaire and the Knee injury and Osteoarthritis Outcome Score (KOOS) were used to evaluate the results, and the visual analog scale was used to assess the pain scores. Magnetic resonance imaging (MRI) scans were obtained in the preoperative period and at postoperative months 1, 12, 24, and 36 to assess the scaffold position as well as chondral degeneration/damage in a comparative manner. MRI assessment was performed by using the modified Outerbridge scale for cartilage and the Genovese scoring system for the meniscal implant. Twenty-three patients who were included in the study were evaluated for a mean follow-up period of 38.3 months. Patients exhibited statistically significant improvement according to all scoring data from the preoperative period until the follow-up period. The mean postoperative extrusion at year 3 was 2.39 mm (distribution 2.30–2.56 mm). There was no significant difference in the distribution of the degree of chondral damage between the preoperative and 3-year follow-up periods. Four patients did not show any improvement nor had lower scores according to the assessment. Medial meniscus scaffold implantation combined with intra-articular CBMA injection resulted in a significant improvement in all functions and pain scores as well as a statistically significant clinical improvement in IKDC and KOOS values in the short-term follow-up. The Level of evidence for this study is IV.

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Actifit® synthetic meniscal substitute: Experience with 18 patients in Brest, France

Abstract: IV.

Cited by 51 publications

References 6 publications

Meniscal Transplants and Scaffolds: A Systematic Review of the Literature

Meniscal Transplants and Scaffolds: A Systematic Review of the Literature

Meniscus tear surgery and meniscus replacement

Medial Meniscus Scaffold Implantation in Combination with Concentrated Bone Marrow Aspirate Injection: Minimum 3-Year Follow-up

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