ACTH Secretion from a Functioning Pheochromocytoma

Spark, Richard F.; Connolly, Peter B.; Gluckin, Doreen S.; White, Robert J.; Sacks, Barry; Landsberg, Lewis

doi:10.1056/nejm197908233010807

Cited by 78 publications

(17 citation statements)

References 18 publications

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“…In 1983, Sato et al reviewed 526 Japanese cases of pheochromocytoma and reported that three of them were associated with papillary thyroid carcinoma [14]. Pheochromocytomas are capable of producing and secreting a number of peptides such as insulin-like growth factor II [15], hypothalamic-like and pituitary-like hormones [16]. These biological substances might cause the development and growth of papillary thyroid carcinoma [10].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Pheochromocytoma Associated with Paraganglioma and Papillary Thyroid Carcinoma: Report of an Unusual Case

et al. 2007

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Abstract. A 42-year old woman presented with headache, palpitation and facial flushing. Ultrasonograms and computed tomograms revealed tumors in both of the adrenal glands, anterior aspect of the inferior vena cava, and the right lobe of the thyroid gland. Fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. Serum calcitonin, CEA, intact PTH and calcium levels were within normal limits. Markedly elevated levels of urinary normetanephrine and vanillylmandelic acid, and the result of 131 I-metaiodobenzylguanidine ( 131 I-MIBG) scintigraphy indicated that both adrenal masses were pheochromocytoma. Bilateral adrenalectomy, paracaval mass removal and total thyroidectomy together with central lymph node dissection were performed. The final pathological diagnosis was bilateral adrenal pheochromocytoma, paraganglioma, papillary thyroid carcinoma and either parathyroid adenoma or hyperplasia. Analysis of the RET proto-oncogene mutation, von Hippel Lindau mutation, succinate dehydrogenase subunit B mutation, and succinate dehydrogenase subunit D mutation yielded negative results. The relationship of these lesions could not be determined. This is the first report of a combination of bilateral pheochromocytoma, abdominal paraganglioma, papillary thyroid carcinoma and either parathyroid adenoma or hyperplasia without hyperparathyroidism.

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Section: Discussionmentioning

confidence: 99%

Bilateral Pheochromocytoma Associated with Paraganglioma and Papillary Thyroid Carcinoma: Report of an Unusual Case

et al. 2007

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“…Hypercalcaemia has been reported in some patients with pheochromocytoma perhaps due to parathyroid hormone-related peptide (Heath and Edis, 1979;Steiner et al, 1968;Stewart et al, 1985). In addition, pheochromocytoma has presented as Cushing's syndrome with the tumor as the ectopic source of ACTH (Spark et al, 1979). Rarely, pheochromocytoma has produced vasoactive intestinal peptide with resultant watery diarrhoea, hypokalaemia and achlorhydria (Verner-Morrison syndrome) (Viale et al, 1985).…”

Section: Clinical Presentationmentioning

confidence: 99%

Pheochromocytoma and Paraganglioma

Pacák

Wimalawansa

2015

Endocrine Practice

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“…A causal link has been suggested between the release of catecholamines and HPA-axis function (Spark et al, 1979). Dexamethasone administration, for example, suppresses plasma noradrenaline levels (Stene et al, 1980) and plasma MHPG (Wolkowitz et al, 1987) in normal controls.…”

Section: Introductionmentioning

confidence: 99%

Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia

Maes¹,

Minner²,

Suy³

et al. 1991

J. Neural Transmission

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In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.

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ACTH Secretion from a Functioning Pheochromocytoma

Cited by 78 publications

References 18 publications

Bilateral Pheochromocytoma Associated with Paraganglioma and Papillary Thyroid Carcinoma: Report of an Unusual Case

Bilateral Pheochromocytoma Associated with Paraganglioma and Papillary Thyroid Carcinoma: Report of an Unusual Case

Pheochromocytoma and Paraganglioma

Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia

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