Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest

Ciardelli, Gianluca; Cioni, Beatrice; Cristallini, Caterina; Barbani, Niccoletta; Silvestri, Davide; Giusti, P.

doi:10.1016/j.bios.2004.06.028

Cited by 62 publications

(24 citation statements)

References 25 publications

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“…In addition, there are few papers that provide simultaneous information about the influence of the functional monomer/template ratio on the affinity of the cavities (after removing the template) for the template molecules and on their release kinetics. [12,20] The aim of this study is to elucidate the imprinting conditions at which the enhanced affinity of the imprinted hydrogels for the template drug can significantly contribute to control the release process. To carry out the work, hydrogels were prepared using different amounts of functional monomer (100-400 mmol), cross-linker (150-600 mmol), and template drug (timolol).…”

Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Imprinted Hydrogels by Modifying the Characteristics of the Imprinted Cavities

Hiratani

Mizutani

Alvarez‐Lorenzo

2005

Macromolecular Bioscience

144

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The aim of this study was to analyse the influence of the template/functional monomer proportion on the achievement of molecularly imprinted hydrogels with cavities with a high enough affinity for the drug to sustain drug release. Imprinted hydrogels were prepared from N,N-dimethylacrylamide and tris(trimethylsiloxy)sililpropyl methacrylate (DMAA and TRIS; main components), methacrylic acid (MAA; functional monomer), ethylene glycol dimethacrylate (EGDMA; cross-linker), and timolol (template drug). Photo-polymerization of the monomer solutions was carried out in poly(propylene) molds (0.3 mm thickness) to obtain contact lens-like devices. Non-imprinted control hydrogels were also prepared in the same way but without the addition of timolol. The imprinted hydrogels showed a higher affinity for timolol and a slower release rate than the non-imprinted hydrogels. The release rate decreased by increasing the MAA/timolol ratio in the gel recipe. Hydrogels prepared with 400 x 10(-3) M MAA, 600 x 10(-3) M EGDMA, and a timolol/MAA mole ratio of 1:16-1:32 had drug diffusion coefficients two orders of magnitude below those of non-imprinted hydrogels. The results obtained clearly indicate that the timolol release rate is critically affected by the conditions under which the hydrogels were synthesized. These effects are discussed on the basis of the influence of drug proportion on the conformation of the imprinted cavities.

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Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Imprinted Hydrogels by Modifying the Characteristics of the Imprinted Cavities

Hiratani

Mizutani

Alvarez‐Lorenzo

2005

Macromolecular Bioscience

144

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“…Sulfasalazine-imprinted particles can sustain drug release more efficiently than the corresponding nonimprinted particles both at pH 1 and 6.8 [241]. Theophylline-imprinted systems with modulated loading capacities and release rates were obtained using different proportions of MAA and methylmethacrylate (MMA) functional monomers [242]. Recently, light-responsive-imprinted microparticles using a methacrylate azo functional monomer have been prepared applying precipitation polymerization under dark conditions.…”

Section: Polymeric Particles From Monomersmentioning

confidence: 99%

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Álvarez-Lorenzo

Puga

2012

Biomimetic Approaches for Biomaterials Development

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“…Essa mistura (reagentes e solvente) é degaseificada e acondicionada em banho-maria à temperatura de 60 o C por 24 h. A polimerização inicia-se de maneira pontual e o crescimento do MIP resulta da captura de oligômeros nascentes presentes na solução. A precipitação ocorre quando a microesfera adquire densidade maior que a solução (Pouci et al, 2004;Ciardelli et al, 2004;Ulubayram, Tunc, Baykara, 2007). Yoshimatsu et al (2007) sintetizaram um MIP seletivo para propranolol por meio de polimerização por precipitação.…”

Section: Polimerização Por Precipitaçãounclassified

Impressão molecular: uma estratégia promissora na elaboração de matrizes para a liberação controlada de fármacos

Figueiredo¹,

Dias²,

Arruda³

2008

Rev. Bras. Cienc. Farm.

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Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest

Cited by 62 publications

References 25 publications

Controlling Drug Release from Imprinted Hydrogels by Modifying the Characteristics of the Imprinted Cavities

Controlling Drug Release from Imprinted Hydrogels by Modifying the Characteristics of the Imprinted Cavities

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Impressão molecular: uma estratégia promissora na elaboração de matrizes para a liberação controlada de fármacos

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