Acrylic bone cement in total joint arthroplasty: A review

Saleh, Khaled J.; El-Othmani, Mouhanad M.; Tzeng, Tony H.; Mihalko, William M.; Chambers, Monique C.; Grupp, Thomas M.

doi:10.1002/jor.23184

Cited by 63 publications

(50 citation statements)

References 97 publications

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“…The possibility of Cementless vertebroplasty remains unknown. Saleh and his colleagues have indicated cementless fixation may have a positive stint in younger population [22].…”

Section: Drug Delivery System Porous Pmma and Cementless Proceduresmentioning

confidence: 99%

“…Also, the viscosity steadily increases during the PMMA polymerization process. The storage and loss moduli increase over time as the PMMA polymerization progresses [22]. In addition, the bone cement should be injected at the latest time point possible in order to prevent leakage and extravasation.…”

Section: Pmma Viscosity Behaviormentioning

confidence: 99%

“…In addition, a greater chance of embolism and reduction in arterial oxygenation resulting in circulatory failure was observed in the hand-mixed PMMA when compared to the vacuum-mixed PMMA [24]. It has been further reported that drilling a hole with and without vacuum can potentially reduce the intraosseous pressure and, thus, reduce the risk of emboli [22]. Factors such as viscosity, permeability in cancellous bone, and biomechanical strength of the mixture also play a crucial role [14].…”

Section: Pmma Viscosity Behaviormentioning

confidence: 99%

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A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Shridhar¹,

Chen²,

Khalil³

et al. 2016

Preprint

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Percutaneous vertebroplasty procedure is of major importance, given the significant increasing aging population and higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main features of PMMA bone cement on the heart, and the extent of influence of materials on cardiac embolism. Clinically, cement leakage results in life-threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case report.

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“…The possibility of Cementless vertebroplasty remains unknown. Saleh and his colleagues have indicated cementless fixation may have a positive stint in younger population [22].…”

Section: Drug Delivery System Porous Pmma and Cementless Proceduresmentioning

confidence: 99%

Section: Pmma Viscosity Behaviormentioning

confidence: 99%

Section: Pmma Viscosity Behaviormentioning

confidence: 99%

See 1 more Smart Citation

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Shridhar¹,

Chen²,

Khalil³

et al. 2016

Preprint

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show abstract

“…Antibiotic-loaded PMMA will continue to serve important roles in a limited set of cases in which removal is not necessary, such as in the anchoring of a prosthetic device. This was the initial application of antibiotic-loaded PMMA cement, and this practice is still common today [26,29]. Currently, antibiotic-laden PMMA formulations continue to be improved, with combination therapies such as vancomycin or clindamycin added to gentamicin for a synergistic effect in preventing infection [29–31].…”

Section: 0 Bodymentioning

confidence: 99%

“…This was the initial application of antibiotic-loaded PMMA cement, and this practice is still common today [26,29]. Currently, antibiotic-laden PMMA formulations continue to be improved, with combination therapies such as vancomycin or clindamycin added to gentamicin for a synergistic effect in preventing infection [29–31]. On the other hand, bone tissue engineering has advanced greatly in the last few decades, facilitating the development of improved biodegradable scaffolds of both natural and synthetic polymers.…”

Section: 0 Bodymentioning

confidence: 99%

Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis

Ford

Cassat

2017

Expert Review of Anti-infective Therapy

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Structured Abstract Introduction Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies. Areas Covered Following surgical debridement, tissue voids require implanted materials to facilitate the healing process. Antibiotic-loaded, non-biodegradable implants have been the standard of care. However, a new generation of biodegradable, osteoconductive materials are being developed. Additionally, in the face of widespread antimicrobial resistance, alternative therapies to traditional antibiotic regimens are being investigated, including bone targeting compounds, antimicrobial surface modifications of orthopedic implants, and anti-virulence strategies. Expert Commentary Recent advances in biodegradable drug delivery scaffolds make this technology an attractive alternative to traditional techniques for orthopedic infection that require secondary operations for removal. Advances in novel treatment methods are expanding the arsenal of viable antimicrobial treatment strategies in the face of widespread drug resistance. Despite a need for large scale clinical investigations, these strategies offer hope for future treatment of this difficult invasive disease.

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Injectable Functional Biomaterials for Minimally Invasive Surgery

Raucci

D’Amora

Ronca

et al. 2020

Adv Healthcare Materials

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Injectable materials represent very attractive ready‐to‐use biomaterials for application in minimally invasive surgical procedures. It is shown that this approach to treat, for example, vertebral fracture, craniofacial defects, or tumor resection has significant clinical potential in the biomedical field. In the last four decades, calcium phosphate cements have been widely used as injectable materials for orthopedic surgery due to their excellent properties in terms of biocompatibility and osteoconductivity. However, few clinical studies have demonstrated certain weaknesses of these cements, which include high viscosity, long degradation time, and difficulties being manipulated. To overcome these limitations, the use of sol‐gel technology has been investigated, which has shown good results for synthesis of injectable calcium phosphate‐based materials. In the last few decades, injectable hydrogels have gained increasing attention owing to their structural similarities with the extracellular matrix, easy process conditions, and potential applications in minimally invasive surgery. However, the need to protect cells during injection leads to the development of double network injectable hydrogels that are capable of being cross‐linked in situ. This review will provide the current state of the art and recent advances in the field of injectable biomaterials for minimally invasive surgery.

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Acrylic bone cement in total joint arthroplasty: A review

Cited by 63 publications

References 97 publications

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis

Injectable Functional Biomaterials for Minimally Invasive Surgery

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