Acrylamide encephaloneuropathy due to well water pollution.

Igisu, Hideki; Goto, I; Kawamura, Y; Kato, Mayumi Kobayashi; Izumi, Kae

doi:10.1136/jnnp.38.6.581

Cited by 122 publications

(50 citation statements)

References 6 publications

(11 reference statements)

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“…However, AMD is also easily metabolized and is largely excreted as metabolites in urine and bile, although fecal excretion is minimal in hours to a few days (Miller et al, 1982). AMD exposures have resulted in isolated human fatalities and temporary injury or impairment with ingestion or extensive exposure to concentrations of over 400-ppm AMD (Garland and Patterson, 1967;Igisu et al, 1975). However, the exposure levels required to cause neurotoxic or carcinogenic effects in humans are several orders of magnitude above those conceivable from exposures resulting from current environmental applications.…”

Section: Pam Safety Field Retention and Environmental Impactsmentioning

confidence: 99%

Polyacrylamide in Agriculture and Environmental Land Management

Sojka

Bjorneberg

Entry

et al. 2007

Advances in Agronomy

347

240

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Section: Pam Safety Field Retention and Environmental Impactsmentioning

confidence: 99%

Polyacrylamide in Agriculture and Environmental Land Management

Sojka

Bjorneberg

Entry

et al. 2007

Advances in Agronomy

347

240

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“…The peripheral nervous system is clearly damaged and both human and experimentally-induced neuropathies have been described (Tilson et al 1979;Fullerton and Barnes 1966;Fujita et al 1961). Central nervous system malfunction is also reported for experimental animals and humans (Igisu et al 1975;Spencer and Schaumburg 1974). Involvement of the sympathetic nervous system has long been suspected (Auld and Bedwell 1967) and recently both the dopamine and serotonin neuronal circuits have been found abnormal in the brains of acrylamide-treated rats .…”

Section: Introductionmentioning

confidence: 98%

Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones

et al. 1983

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Abstract. The effect of acute and subchronic acrylamide treatment on levels of dopamine, serotonin, and their metabolites was determined in several brain regions of the rat. Concentrations of several neuropeptides and circulating hormones were also measured. Both a single and repeated doses of acrylamide resulted in elevated levels of 5-hydroxyindolacetic acid in all regions studied (frontal cortex, striatum, hippocampus, brain stem, and hypothalamus). Changes in regional content of other monoamines were much less pronounced. Turnover studies following pargyline blockage of monoamine oxidase, suggested results were due to increased rates of serotonin turnover in acrylamide-treated rats.Changes in neuropeptide levels were only detected in the hypothalamus where a single acrylamide treatment caused elevated levels of fi-endorphin and substance P, and in frontal cortex where met-enkephalin levels were higher after repeated acrylamide injection. Such repeated injection caused a major depression in plasma levels of testosterone and prolactin.

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“…More recently central nervous system involvement in acrylamide poisoning has also been reported in experimental animals (Ghetti et al, 1973;Gipon et al, 1977;Schotman et al, 1978;Schaumburg and Spencer, 1978). Acrylamide poisoning leading to distinct 89 central nervous system behavioral deficits and encephalopathy has also been reported (Fujita et al, 1961;Igisu et al, 1975).…”

mentioning

confidence: 97%

The effects of acrylamide treatment upon the dopamine receptor

Agrawal

Squibb

Bondy

1981

Toxicology and Applied Pharmacology

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. (1981). Toxicol. Appl. Pharmacol. 58,[89][90][91][92][93][94][95][96][97][98][99]. The binding of tritiated spiroperidol to striatal membranes prepared from acrylamide-treated male 6-week-old rats and matched controls has been studied. This binding has highaffinity characteristics and is stereospecific and reversible. Equilibrium was attained within 15 min at 37°C. The extent of binding was much more pronounced in the striatum than in any other brain region and was not detectable within the cerebellum or spinal cord. Regional distribution of binding and competition studies with other pharmacologic agents suggested a correspondence between the location of ligand-membrane complex formation and the dopamine receptor. Twenty-four hours after a single oral administration of acrylamide there was a significant increase in [ 3 H]spiroperidol binding at all acrylamide doses tested (50, 100, and 200 mJYkg body weight). However, there was no significant change in striatal dopamine levels of treated animals. Kinetic analysis of animals treated with 100 mg acrylamide/kg suggested increased affinity of receptors of treated animals toward the labeled ligand. Receptor densicy was only slightly elevated in experimental animals. Effects were also studied in rats that had received 10, 20, or 30 mg/kg acrylamide daily for 10 days. Twentyfour hours after the last dose there was a major increase in spiroperidol binding in treated animals. Scatchard plot analysis again revealed that this change was largely attributable to a change in the dissociation constant of the binding interaction but also there was an increase in the overall number of receptor sites. Nonna! values were restored within 8 days after cessation of dosing. This illustrates that, under the conditions of this experiment, the effect of acrylamide on a central neurotransmitter system is reversible.

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Acrylamide encephaloneuropathy due to well water pollution.

Cited by 122 publications

References 6 publications

Polyacrylamide in Agriculture and Environmental Land Management

Polyacrylamide in Agriculture and Environmental Land Management

Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones

The effects of acrylamide treatment upon the dopamine receptor

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