Acrylamide axonopathy revisited

LoPachin, Richard M.; Balaban, Carey D.; Ross, Joseph F.

doi:10.1016/s0041-008x(02)00072-8

Cited by 162 publications

(89 citation statements)

References 119 publications

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“…It was fi rst synthesized in United States in 1950s and used in several industrial fi elds such as textile, paper and cosmetics. ACR is neurotoxic, genotoxic and highly carcinogenic to humans and animals (2,3). The experimental research shows that administering acrylamide in certain doses and periods may have toxic and carcinogenic effects on animals and humans (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…ACR is neurotoxic, genotoxic and highly carcinogenic to humans and animals (2,3). The experimental research shows that administering acrylamide in certain doses and periods may have toxic and carcinogenic effects on animals and humans (2)(3)(4)(5). It has been proven that cooking foods at high temperature leads to high level of acrylamide to form and this fact has been an important milestone for studies related to acrylamide (6,7).…”

Section: Introductionmentioning

confidence: 99%

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The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Altınöz¹,

Türköz²,

Vardı³

2015

BLL

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Abstract:The aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats. The rats were divided into four groups. Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05). But acrylamide+NAC administration decreased MDA levels signifi cantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05). GSH levels in liver and small intestine tissues reduced signifi cantly in the acrylamide group (p < 0.05). But acrylamide+NAC administration increased GSH levels signifi cantly in all tissues. Whereas GST activity decreased signifi cantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased signifi cantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05). Liver histopathology showed that the liver epithelial cells were damaged signifi cantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged signifi cantly in the acrylamide group. Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Altınöz¹,

Türköz²,

Vardı³

2015

BLL

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“…AA is neuro-toxic, 3 ) clastogenic , 4 ) and mutagenic in somatic and germ cells in rodents 4 , 5 ) and is considered as a probable carcinogen in humans.…”

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confidence: 99%

Estimation of the Daily Human Intake of Acrylamide (AA) Based on Urinary N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and the Contribution of Dietary Habits in South Korean Adults

Lee¹,

Lee²,

Kang³

2016

Korean Journal of Environmental Health Sciences

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Objectives: This study estimated the adult Korean daily intake of acrylamide (AA) and investigated its relationship with demographic, lifestyle and dietary habits by using urinary concentrations of N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA).Methods: Human data (n=1870) was collected in a nationwide cross-sectional biomonitoring program representing the population (18-69 years) residing in South Korea. Urinary AAMA was analyzed with a LC-MS/MS system. Daily intakes of AA were estimated using mass daily AAMA, which was calculated through urinary AAMA concentration and daily creatinine excretion. Statistical analysis was performed with SAS procedures for calculating geometric means, confidence intervals and the exponentiated beta coefficient of multiple linear regressions.Results: Daily intake of AA was estimated at 0.475 µg/kg body weight (BW) per day (95% confidence interval (CI): 0.447-0.503). In the case of current smokers, AA intake was 0.957 µg/kg BW per day (95% CI: 0.847-1.067), which was significantly higher than that of former smokers and never smoked (p<0.0001). The strong affecting factors were age (95% CI: 0.68-1.14; p=0.0180), education level (95% CI: 1.05-1.42; p=0.0163), body mass index (BMI) (95% CI: 1.00-1.82; p<0.0001), and smoking status (95% CI: 0.97-3.05; p<0.0001). Korean dietary habits increasing AA intake were coffee (p=0.0005), cup noodles (p=0.0010) and canned foods (p=0.0005). Meanwhile, foods decreasing AA intake were fresh fruit (p=0.0076), cooked beef (p=0.0335) and cooked pork (p=0.0147). Conclusion:The Korean daily intake of AA in adults was estimated to be similar with those found in developed countries. The factors increasing daily AA intake were coffee, cup noodles and canned foods, and decreasing factors were fresh fruit, cooked beef and cooked pork.

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“…LoPachin et al [21] reported that the cumulative neurotoxicity produced by ACR exposure was linked to nerve terminal damage in the central nervous system (CNS) and peripheral nervous system (PNS). At the molecular level, this presynaptic toxicity appears to be mediated by the formation of sulfhydryl adducts on the cysteine residues of many proteins [22] .…”

Section: Discussionmentioning

confidence: 99%

“…The dissociation between neurological dysfunction and the presumed underlying morphological lesion suggests that axonopathy might not be importantly involved in the pathophysiological process leading to ACR neurotoxicity. Nerve terminals have been suggested as an alternative site of ACR action based on early structural and functional changes as in PNS and CNS [21] .…”

Section: Discussionmentioning

confidence: 99%

Hazardous effects of fried potato chips on the development of retina in albino rats

El‐Sayyad

Sakr

Badawy

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Acrylamide axonopathy revisited

Cited by 162 publications

References 119 publications

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Estimation of the Daily Human Intake of Acrylamide (AA) Based on Urinary N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and the Contribution of Dietary Habits in South Korean Adults

Hazardous effects of fried potato chips on the development of retina in albino rats

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