Across-breed genomic prediction for body weight in Siberian cattle populations

Abstract

Body weight (BW) is an important heritable phenotype and related to other functional and production traits in cattle. The past decade has seen an increase in emphasis on genome wide association studies (GWAS) for detecting single nucleotide polymorphisms (SNPs) that are associated with quantitative phenotypes. Prediction of phenotypes using across-breed GWAS information [genomic prediction (GP)] is an also important research area but received less attention from the community. Understanding the link between major genes and common ancestors within and between breeds will contribute to a deeper understanding of GP across breeds. The aims of the present study were two-fold: 1) to examine genetic structure and to detect associated SNPs for BW using various single and multiple locus genomic models and 2) genomic prediction of BW using Siberian cattle populations based on across-breed genomic information. The most obvious finding to emerge from this study was the increase in the across-GP accuracy when gene segregation in both related populations was found. These findings have significant implications for the understanding of the way in which common ancestors and/or the presence of quantitative trait loci might affect the accuracy of the GP results.

Early Detection of Candidate Genes for Body Weight in Indonesian Cattle Breeds with Genome-Wide Association Study (GWAS)

“…The GWAS in Russian cattle reveals the Bonferroni corrected threshold of -Log 10 = 5.0 to 6.0 of the body weight [24]. The Bonferroni corrected threshold can be affected by statistical analysis models used to select SNP markers [25]. The SNP markers with the highest Bonferroni corrected value also indicate the most signifi cant makers of observed traits.…”

“…According to previous studies, BTA12 has the SNP markers signifi cantly associated with body weight gain [8] and yearling height [26] of cattle. Many SNP markers for the weight of cattle were determined from BTA3 of Nellore cattle [8], BTA11, BTA22, and BTA27 of Braunvieh and Canchim cattle [23,27], BTA 5 of Russian cattle [25], and BTA14 of European cattle [28]. In Charolais cattle, mostly the SNP markers for yearling weight (BW1) were determined from BTA6 [10].…”