Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications

Abstract

Elastic and ultradeformable liposomes were synthesized and physicochemically characterized to make suitable topical formulations for delivering the anti-inflammatory and anticancer compound 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The average sizes of elastic and ultradeformable liposomes are below 300 nm, while the size distribution and Z-potential are below 0.3 and - 25 mV, respectively. The presence of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable liposomes show a zero order release kinetic and are stable at room temperature for a long time with or without 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The ultradeformable liposomes are more deformable than elastic liposomes. These differences may depend on sodium cholate derivatives making nanoformulations. The 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based natural compounds for the potential treatment of cutanous inflammation.

Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases

“…They are made up of phospholipids and sodium cholate, which acts as an edge activator by decreasing the interfacial tension and hence increasing the deformability of the vesicle bilayers [15]. Thanks to their great deformability, the intact permeation of transfersomes ® through the skin owing to an aqueous transmembrane osmotic gradient in non-occlusive conditions has been described [21].…”

<p>Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug</p>

“…The variation of average transmitted intensity (ΔT) and turbiscan stability index (TSI) calculated from the signal value of transmission light were employed as main parameters to evaluate the stability of the nanoparticle suspensions. 14,[31][32][33] The long-term storage stability of nanoparticles was monitored at 4°C for 3 months. The appearance, particle size, zeta potentials, content, and entrapment efficiency were determined to evaluate the stability of nanoparticles.…”

“…[8][9][10] Lecithin, a negatively charged lipid mixture of phospholipids, is the primary constituent of cell membranes and has been commonly used for the preparation of various nanoparticles. [11][12][13][14] LCNs are formed through self-assembly of negatively charged lecithin and positively charged chitosan via electrostatic interactions. The inner core is the hydrophobic lipid and can be utilized for encapsulation of lipophilic drugs, whereas the hydrophilic chitosan constitutes the outer shell and provides stabilization.…”

Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

“…Hydrodynamic diameter (Dh), the polydispersity index (PDI) and the ζ-potential of liposomes were analyzed as previously reported [39,40] using a Malvern Zetasizer Nano ZS90 (Malvern Instrument, Ltd.). For both analyses, liposome suspensions were diluted to 100 µg/mL in 10-mM HEPES pH 7.4 to avoid multiscattering phenomena.…”