Acromegaly with multiple secreting pituitary adenomas

Hashimoto, Nobuo; Handa, Hajime; Yamagami, Tatsuhito; Kojima, Masayasu; Aoki, Masamitsu; Okamoto, Shigeru; Kato, Y; Imura, Hiroo

doi:10.1016/0090-3019(84)90431-2

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Among 42 patients (Table III), 22 (52.4%) were diagnosed on the basis of preoperative MRI findings, and 2 (4.8%) on the basis of CT findings (24). The remaining 18 patients were diagnosed during surgery.…”

Section: Postoperative Values ---------------------------------------mentioning

confidence: 99%

Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature

Wang

Zhou

et al. 2016

Oncology Letters

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Abstract. Only a few cases of double or multiple pituitary adenomas have previously been reported in the literature; however, isolated double adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are even more rare. The present study reports a rare case of a 50-year-old female patient who presented with typical clinical features of Cushing's disease and was diagnosed with isolated double ACTH-secreting pituitary adenomas. Endocrinological examination revealed an ACTH-producing pituitary adenoma, and preoperative magnetic resonance imaging (MRI) demonstrated a microadenoma with a lower intensity on the right side of the pituitary gland. The patient underwent endoscopic endonasal transsphenoidal surgery, which revealed another pituitary tumor in the left side of the pituitary gland. The two, clearly separated, pituitary adenomas identified in the same gland were completely resected. Immunohistochemistry and pathology revealed that the clearly separated double pituitary adenomas were positive for ACTH, thyroid-stimulating, growth and prolactin hormones. Postoperatively, the levels of ACTH and cortisol hormone decreased rapidly. The case reported in the present study is considerably rare, due to the presence of a second pituitary adenoma in the same gland, which was not detected by preoperative MRI scan, but was noticed during surgery. Intraoperative evaluation may be important in the identification of double or multiple pituitary adenomas.

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Section: Postoperative Values ---------------------------------------mentioning

confidence: 99%