Acromegaly and pituitary tumors: Early anatomoclinical observations

Brunori, Andrea; Bruni, P; Delitala, Alberto; Chiappetta, F

doi:10.1016/0090-3019(95)00008-9

Surgical Neurology

1995

DOI: 10.1016/0090-3019(95)00008-9

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Acromegaly and pituitary tumors: Early anatomoclinical observations

Andrea Brunori

P Bruni

Alberto Delitala

et al.

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Cited by 5 publications

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“…The pituitary tissue, however, was considered hypertrophied, not neoplastic, and simply another manifestation of the same inexplicable process that enlarged so many other parts of the body. The essential pituitary role in acromegaly has since been illuminated [5, 17, 20, 21]. …”

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confidence: 99%

Governor Pio Pico, the monster of California…no more: lessons in neuroendocrinology

2008

Pituitary

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We hypothesize that Pio Pico, the last Mexican Governor of California, had acromegaly between at least ages 43 to 57, from 1844 to 1858, before Pierre Marie published the clinical description of acromegaly in 1886. Pico’s probable growth hormone-secreting pituitary tumor likely infarcted spontaneously after 1858. The tumor infarction resulted in burnt-out acromegaly and probably restored normal pituitary function. Pearce Bailey published the first account of pituitary tumor infarction only in 1898. Pico’s undiagnosed, misunderstood, profoundly acromegalic appearance was widely misinterpreted, leading to pervasive, degrading, and highly prejudicial comments. This landmark case study in neuroendocrinology provides the opportunity to re-examine elements of 19th century California and American history.

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confidence: 99%

Governor Pio Pico, the monster of California…no more: lessons in neuroendocrinology

2008

Pituitary

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Pituitary tumors: surgical and medical management

Yeh

Chen

1997

Surgical Oncology

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Potentially reversible conditions in 1000 consecutive memory clinic patients

Hejl

Høgh²,

Waldemar³

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

135

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Objectives: To investigate the prevalence and classification of potentially reversible conditions in a prospective memory clinic cohort of younger and elderly patients with cognitive symptoms. Patients: 1000 consecutive patients referred during a period of 54 months to a university hospital multidisciplinary memory clinic based in neurology. Methods: All patients were referred for diagnostic evaluation and treatment of cognitive symptoms. The multidisciplinary staff prospectively established a standardised consensus report for each patient based on the results of clinical and ancillary investigations with classification of cognitive profile, primary underlying cause, and concomitant conditions. Results: The mean age of the patients was 66.1 years (range 17-98) and 43% met diagnostic criteria for dementia. A potentially reversible primary aetiology for cognitive symptoms was identified in 19% and a potentially reversible concomitant condition in 23% of all patients. In the subgroup of patients with dementia, 4% had a potentially reversible primary aetiology. Careful clinical examination, routine laboratory tests, and cranial computed tomography identified most of these conditions. Conclusions: Reversible conditions are most often encountered in patients with mild cognitive disturbances. Although treatment may not always result in full reversal of cognitive symptoms, potentially reversible conditions should be identified in the diagnostic evaluation of the patient.

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Acromegaly and pituitary tumors: Early anatomoclinical observations

Cited by 5 publications

References 3 publications

Governor Pio Pico, the monster of California…no more: lessons in neuroendocrinology

Governor Pio Pico, the monster of California…no more: lessons in neuroendocrinology

Pituitary tumors: surgical and medical management

Potentially reversible conditions in 1000 consecutive memory clinic patients

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