Acromegaly — A Case Report with Dentist's Perspectives and Review of Literature

Kaur, Milanjeet; Sankireddy, Shailaja; Chandra, Sharath; Mamatha, B.

doi:10.1177/2229411220120203

Cited by 5 publications

(2 citation statements)

References 14 publications

(26 reference statements)

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“…According to the literature, orthopantomography does not play a significant role in identifying the pathognomonic signs of the disease. It has been reported that only the panoramic and intraoral radiographs of these patients can reliably show radiopaque lesions at the level of the roots of the molar elements, defined as "hypercementosis" [23,28,29,43,47]. An observational study comparing the teleradiographs of the skulls of healthy subjects and acromegaly patients found that in a significant number of cases, the orthopantomography examination revealed morphological alterations of the diameter of the mandibular canal and enlargement of the mental foramen [48].…”

Section: Thickening Of Gingival Tissues Dental Evaluationmentioning

confidence: 99%

Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review

Stefani

Dassiè

Wennberg

et al. 2022

JCM

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Acromegaly is a chronic disease caused by an abnormal secretion of growth hormone (GH) by a pituitary adenoma, resulting in an increased circulating concentration of insulin-like growth factor 1 (IGF-1). The main characteristics are a slow progression of signs and symptoms, with multisystemic involvement, leading to acral overgrowth, progressive somatic changes, and a complex range of comorbidities. Most of these comorbidities can be controlled with treatment. The literature reveals that the most evident and early signs are those related to soft tissue thickening and skeletal growth, especially in the head and neck region. Methods: The authors reviewed the available literature on the clinical oro-dental features of acromegaly, selecting articles from PubMed and Google Scholar. The aim of this review was to summarize all the reported clinical oro-dental features of acromegalic patients. Results: The most common facial dimorphisms involved the maxillo-facial district, with hypertrophy of the paranasal sinuses, thickening of the frontal bones, and protruding glabella, which may be associated with joint pain and clicks. Regarding the oro-dental signs, the most frequent are dental diastema (40–43%), mandibular overgrowth (22–24%), mandibular prognathism (20–22%), and macroglossia (54–58%). These signs of acromegaly can be significantly reduced with adequate treatment, which is more effective when initiated early. Conclusions: Increased awareness of acromegaly among dentists and maxillo-facial surgeons, along with the early identification of oro-facial changes, could lead to an earlier diagnosis and treatment, thereby improving patients’ quality of life and prognosis.

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Section: Thickening Of Gingival Tissues Dental Evaluationmentioning

confidence: 99%

Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review

Stefani

Dassiè

Wennberg

et al. 2022

JCM

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“…Patients often have cardiovascular problems, diabetes mellitus, phosphocalcic disturbances, and lipid metabolism disorders [4]. On the other hand, this disease causes numerous complications as well as significant structural changes in the oral cavity [5]. The dysmorphic syndrome that characterizes acromegaly is dominated by an enlargement of the thorax and a projection of the sternum forward by the proliferation of costochondral joints, an enlargement of the hands and feet, a thickening of the lips and nose, a protrusion of the superciliary arches due to the pneumatization of the frontal sinuses, a mandibular prognathism and an opening of the gonion angle [5].…”

Section: Introductionmentioning

confidence: 99%

Full-mouth rehabilitation of an acromegaly disease patient with removable prostheses: a clinical case report

et al. 2019

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Acromegaly is a rare disease that can have serious consequences. This disease is not widely known by stomatologists, although cranio-facial manifestations are important and rapid changes in the oral cavity are frequent and sometimes dramatic. The prosthetic management of patients with acromegaly is not easy because it is necessary to wait for the stabilization of the disease. If this is not the case, the bone changes prevent the stability of prostheses over time. Moreover, because of bone remodeling, some treatments are contra-indicated, which limits our therapeutic choices. Through this clinical case, we will focus on the oral manifestations of patients with acromegaly and the method of prosthetic management.

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