Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients

Gugliucci, Alejandro; Lunceford, Nicole; Kinugasa, Eriko; Ogata, Hiroaki; Schulze, John; Kimura, Satoshi

doi:10.1016/j.cca.2007.06.012

Cited by 43 publications

(38 citation statements)

References 33 publications

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“…PON1prevents lipid oxidation: not only of LDL, but also of HDL itself [17]. is protection is probably related to the PON1-hydrolysing activity of some activated phospholipids [18] and/or lipid peroxide [19] products. Human PON1 (aryldialkylphosphatase, EC 3.1.8.1) is a 43 kDa esterase associated with apolipoprotein A1 (apoA-I) and clusterin (apolipoprotein J) in HDL.…”

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confidence: 99%

“…Human PON1 (aryldialkylphosphatase, EC 3.1.8.1) is a 43 kDa esterase associated with apolipoprotein A1 (apoA-I) and clusterin (apolipoprotein J) in HDL. PON1 was shown to possess a peroxidase-like activity, which can contribute to its protective e ect against lipoprotein oxidation, as well as a homocysteinethiolactonase activity, which may be linked with its antiatherogenic properties [19,20].…”

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confidence: 99%

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Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Tabak¹,

Gelışgen²,

Erman³

et al. 2011

CIM

111

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Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus AbstractPurpose: e purpose of this study was to determine the e ects of diabetic complications on oxidation of proteins, lipids, and DNA and to investigate the relationship between oxidative damage markers and clinical parameters.Methods: e study group consisted of 69 type 2 diabetic patients (20 patients without complication, 49 patients with complication) who attended internal medicine outpatient clinics of Istanbul Education and Research Hospital and 19 healthy control subjects. In serum samples of both diabetic patients and healthy subjects, 8-hydroxy-2'deoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, N ε -(hexanoyl)lysine (HEL) and 15-F2t-iso-prostaglandin (15-F2t-IsoP). as products of lipooxidative damage, advanced oxidation protein products (AOPP), as markers of protein damage, and paraoxonase1 (PON1) as antioxidant were studied.Results: 15-F2t-IsoP (p<0.005) and AOPP (p<0.001) levels were signi cantly higher in diabetic group than control group while there were no signi cant di erences in levels of 8-OHdG and HEL between the two groups. AOPP (p<0.001) and 8-OHdG (p<0.001) were signi cantly higher in diabetic group with complications compared to diabetic group without complications.Conclusions: Increased formation of free radicals and oxidative stress, under conditions of hyperglycaemia, is one of the probable causes for evolution of complications in diabetes mellitus. Our study supports the hypothesis that oxidant/antioxidant balance is disturbed in diabetic patients.

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confidence: 99%

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confidence: 99%

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Tabak¹,

Gelışgen²,

Erman³

et al. 2011

CIM

111

View full text Add to dashboard Cite

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“…These findings may explain low PON1 activity in smokers and renal failure individuals (13)(14)(15)(16)(17)(18). Also, some studies have suggested that renal transplantation could decrease the risk of premature vascular aging by increase in PON activity and its anti-atherogenic properties (15)(16)(17)(18)(19). Treatment of CKD can increase PON activity and lower the risk of cardiovascular diseases in these patients.…”

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confidence: 99%

Paraoxonase enzyme activity and dyslipidemia in chronic kidney disease patients

Solati¹,

Mahboobi²

2012

J Nephropathol

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“…Previous studies showed that HD significantly restored PON1 activities. Moreover, an inverse association between PON1 activities recovery after HD was found with creatinine, advanced glycation end products and acrolein, suggesting that uremic toxins may play a mechanistic role in PON1 inactivation [23,24,39,40]. Another possible mechanism of diminished PON1 activity in HD patients involved Hcy a n d / o r i t s m e t a b o l i t e .…”

Section: Discussionmentioning

confidence: 99%

“…We found that serum PON1 lactonase activity was significantly decreased in HD patients compared with normal volunteers. Similarly, serum PON1 activities, including lactonase, were reported to be lower in end-stage renal disease patients undergoing HD compared with healthy controls [23][24][25]39,40]. A lower serum PON1 lactonase activity would be coupled with delayed catabolism of oxidized phospholipids in LDL and oxidized macrophages, and with greater protein homocysteinylation, accelerating atherogenesis [23,24].…”

Section: Discussionmentioning

confidence: 99%

Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis

Zohny¹,

El-Fattah²,

Khan³

2016

CIM

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Purpose: Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potential predictors of native AV fistula thrombosis in chronic HD patients.Methods: This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate.Results: FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P < 0.001). FGF-23 was elevated whereas PON1 lactonase was decreased in HD patients with thrombosed native AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = −0.342, P = 0.017).Conclusions: This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients.

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Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients

Cited by 43 publications

References 33 publications

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Paraoxonase enzyme activity and dyslipidemia in chronic kidney disease patients

Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis

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